Protein arginine methyltransferase 5 (PRMT5) promotes survival of lymphoma cells via activation of WNT/B-catenin and AKT/GSK3B proliferative signaling by Chung, Jihyun

“…We show that PRMT5 stimulates WNT/B-CATENIN signaling through direct epigenetic silencing of pathway antagonists, AXIN2 and WIF1, and indirect activation of AKT/GSK3 signaling.PRMT5 inhibition with either shRNA-mediated knockdown or a specific small molecule PRMT5 inhibitor, CMP-5, not only leads to derepression of WNT antagonists and decreased levels of active phospho-AKT (Thr-450 and Ser-473) and inactive phospho- GSK3B (Ser-9) but also results in decreased transcription of WNT/B-CATENIN target genes, CYCLIN D1, c-MYC, and SURVIVIN, and enhanced lymphoma cell death. …”
Get full text
Get full text

Chemical characterization and therapeutic properties of Achillea biebersteinii leaf aqueous extract synthesized copper nanoparticles against methamphetamine-induced cell death in P... by Wang, G.

“…In this study fresh leaves of A. biebersteinii were used for the biosynthesis of copper nanoparticles. …”
Get full text
Get full text
Get full text

Host genetic variants potentially associated with SARS-CoV-2: A multi-population analysis by Smatti, Maria K.

“…Earlier studies identified single nucleotide polymorphisms (SNPs) associated with SARS-CoV-1 in Eastern Asian (EAS) populations. In this report, we aimed at exploring the frequency of a set of genetic polymorphisms that could affect SARS-CoV-2 susceptibility or severity, including those that were previously associated with SARS-CoV-1. …”
Get full text
Get full text

Host Genetic Variants Potentially Associated With SARS-CoV-2: A Multi-Population Analysis. by Smatti, Maria K

“…Earlier studies identified single nucleotide polymorphisms (SNPs) associated with SARS-CoV-1 in Eastern Asian (EAS) populations. In this report, we aimed at exploring the frequency of a set of genetic polymorphisms that could affect SARS-CoV-2 susceptibility or severity, including those that were previously associated with SARS-CoV-1. …”
Get full text
Get full text

A lipidomic screen of hyperglycemia-treated HRECs links 12/15-Lipoxygenase to microvascular dysfunction during diabetic retinopathy via NADPH oxidase by Ibrahim, Ahmed S.

Get full text
Get full text

Urology Residents' Perspectives on the In-House On-Call Systems: A Study in an Accredited Academic Center by Khalil, Ibrahim A. and Ibrahim, Tarek and Aldeeb, Maya and Mohamed, Ahmed and Ben Salah, Rym and Aboumarzouk, Omar M. and Al-Naimi, Abdulla

“…Quality of life and education: We adopted a validated survey based on a 5-point Likert scale to assess the residents' perception of the transition to a 12-hour on-call system on their quality of life and education. …”
Get full text
Get full text

Investigation of solar PV performance under Doha weather using a customized measurement and monitoring system by Touati, Farid

“…Results predict that the maximum power output from a Poly-crystalline panel decreases by around 30% for a dust exposure of five months. …”
Get full text
Get full text

Decreasing the use of edible oils in China using WeChat and theories of behavior change: study protocol for a randomized controlled trial. by Zhu, Rui

Get full text
Get full text

A 5-year trend in the use of sodium-glucose co-transporter 2 inhibitors and other oral antidiabetic drugs in a Middle Eastern country by Zaghloul, Nancy

“…Results: SGLT2is prescriptions increased from 1045 (2.13%) in 2017 to 8375 (12.39%) in 2020, while sulfonylureas prescriptions declined from 10,436 (21.25%) to 9158 (13.55%) during the same period. …”
Get full text
Get full text

Effect of octylphenol polyethylene oxide on the corrosion inhibition of steel in 0.5 M H2SO4 by Algaber, A.S

“…The experimental data were fitted with the Flory-Huggins isotherm at a molecular ratio of 5:1. The Gibbs energy of adsorption decreases with the temperature. …”
Get full text
Get full text

The Impact of COVID-19 on Physical (In)Activity Behavior in 10 Arab Countries by Al Sabbah, Haleama

“…A total of 12,433 participants were included in this analysis. …”
Get full text
Get full text

A BRET-based Mpro biosensor containing a nanobody and tandem cleavage sites shows an increased cleavage rate by Geethakumari, Anupriya M

“…Here, we report the engineering of a Bioluminescence Resonance Energy Transfer (BRET)-based SARS-CoV-2 main protease (Mpro) biosensor containing the Mpro N-terminal autocleavage sequence in tandem and a nanobody that shows an enhanced rate of Mpro-mediated proteolytic cleavage. …”
Get full text
Get full text
Get full text

Effects of SARS-CoV-2 Alpha, Beta, and Delta variants, age, vaccination, and prior infection on infectiousness of SARS-CoV-2 infections by Qassim, Suelen H.

“…Using the cycle threshold (Ct) value of an RT-qPCR-positive test to proxy the inverse of infectiousness, we investigated infectiousness of SARS-CoV-2 infections by variant, age, sex, vaccination status, prior infection status, and reason for testing in a random sample of 18,355 RT-qPCR-genotyped infections. …”
Get full text
Get full text
Get full text

Experimental analysis of additively manufactured thin-walled heat-treated circular tubes with slits using AlSi10Mg alloy by quasi-static axial crushing test by Mohamed A.S.

“…The bulk of the tested tubes exhibited a crushing force efficiency greater than 0.8. Overall, the presence of slits with length 15 mm and width 5 mm resulted in lower and smoother crushing forces than the straight tubes and, therefore, greater crushing force efficiency, validating them as crashworthy structures.…”
Get full text
Get full text

L5 Spinal Nerve Axotomy Induces Distinct Electrophysiological Changes in Axotomized L5- and Adjacent L4-Dorsal Root Ganglion Neurons in Rats . by Djouhri, Laiche

“…Consistent with this hypothesis, we found (7 days post-SNA), in SNA rats with established pain hypersensitivity, slower AP kinetics in axotomized L5-neurons and faster AP kinetics in L4-nociceptive neurons including decreased rise time in Aδ-and Aβ-fiber nociceptors, and after-hyperpolarization duration in Aβ-fiber nociceptors. …”
Get full text
Get full text

An Eco-Friendly Quaternary Ammonium Salt as a Corrosion Inhibitor for Carbon Steel in 5 M HCl Solution: Theoretical and Experimental Investigation by Jalab, Rem

“…This study aims to investigate the performance of an environment-friendly Quaternium-22 (Q-22) surfactant which is widely used in cosmetics for C-steel corrosion inhibition in a 5 M HCl medium. Weight loss experiments were performed at different concentrations and immersion times, presenting a maximum efficiency at 2.22 mmol·L−1. …”
Get full text
Get full text

An Improved Fault Tolerant Five-Phase Induction Machine Using A Combined Star/Pentagon Single Layer Stator Winding Connection by Abdel-Khalik, Ayman S.

“…For the healthy case, the machine is similar to a conventional star connected five-phase machine. …”
Get full text
Get full text

The impact of COVID-19 pandemic lockdown on smoking habits and lifestyle: A cross-sectional study by Khamees, Almu'atasim

Get full text
Get full text

Effects of a single dose of ivermectin on viral and clinical outcomes in asymptomatic sars-cov-2 infected subjects: A pilot clinical trial in lebanon by Samaha, Ali A.

“…Methods: A randomized controlled trial was conducted in 100 asymptomatic Lebanese subjects that have tested positive for SARS-CoV2. …”
Get full text
Get full text

Evidence by ac-conductivity for the higher mobility of boron (over aluminium)-associated Brønsted sites in boron-modified HZSM-5 by Sayed, Moein B.

“…A correlation ac-conductivity analysis is performed at 102–105 Hz, 373–613 K and 0.8 V for characterizing the effect of increasing boron incorporation in HZSM-5 lattice on altered electric features in BZSM-5 samples of similar origin. …”
Get full text
Get full text
Get full text