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FLCN-deficiency leads to decreased Rho activity in sub-confluent cells and delays in wound closure.
Published 2013“…<b>B)</b> Rho activity was measured using a Rhotekin binding assay at 70% confluence. The FLCN-null UOK257 cells had a 2.5-fold decrease in active Rho levels (Rho GTP) compared to the FLCN re-expressing UOK257-2 cells (n = 3, p<0.05). …”
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Combination metabolic therapy decreases VM-M3 cell proliferation <i>in vitro</i>.
Published 2015“…<b>(B)</b> Combining low glucose, ketone supplementation, and HBOT resulted in a marked decrease in cell proliferation which was significant from control at all time points tested. …”
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Decreased oscillatory flow decreases <i>klf2a</i> expression.
Published 2009“…<p>(A) RFF is decreased by alterations in heart rate. …”
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Thrombin-induced decreased lamellipodia protrusion frequency and actin stress fiber formation.
Published 2015“…Also, in this image a transient opening at a tricellular junction (*) is apparent. …”
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PIN1 silencing leads to decreases in the protein levels of HIF-1α.
Published 2016“…E) ATRA decreases the expression of HIF-1α and PIN1 in HCT116/5xHRE-ODD-luc cells in dose-dependent manner. …”
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Delphinidin alters VEGF-A splicing to increase VEGF-A<sub>165</sub>b and decrease total VEGF-A expression.
Published 2019“…<p><b>A)</b> Treatment of podocytes with delphinidin chloride (10 μg/ml) under normal glucose (NG; 5 mM glucose + 25 mM mannitol) and high glucose (HG; 30 mM glucose, 1 ng/ml TNFα, 1 ng/ml IL-6, and 100 nM insulin) for 48 hrs increased the protein expression of VEGF-A<sub>165</sub>b relative to total VEGF-A<sub>165</sub> (quantified in <b>B</b>; *p<0.05 vs NG, †p<0.05 vs HG; n = 3 biological repeats; One-way ANOVA with Bonferroni post-hoc test for comparison between pairs; <b>A</b>—the same blot was first probed with VEGF-A<sub>165</sub>b before stripping and reprobing with panVEGF-A). …”
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Development of a CRISPR/Cas-Based Detection Platform for Tracking Decreased Susceptibility to Cephalosporins in Neisseria gonorrheae
Published 2025“…We have developed the Multiplex Integrated RPA-CRISPR/Cas12a detection Assay (MIRCA) for simultaneous detection of Neisseria gonorrheae (<i>Ng</i>) and mutations with decreased susceptibility to cephalosporins. MIRCA enables multiplex detection of <i>Ng</i> and single-nucleotide polymorphisms in resistance-associated genes within 40 min, with high specificity and sensitivity (10–20 copies/reaction). …”
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