Progress toward implementing the Swiss Hepatitis Strategy: Is HCV elimination possible by 2030? by Beat Müllhaupt (416436)

“…Given the current standard of care, total viremic infections are expected to decline by 45%, while cases of decompensated cirrhosis, hepatocellular carcinoma, and liver-related deaths will decrease by 20%. If treatment and diagnosis efforts were to cease in 2018, late stage HCV-related morbidity and mortality would increase by 90–100% by 2030. …”

X-ChIP based affinity purification provides the most inclusive analysis of nucleoid associated proteins. by Nina Rajala (693865)

“…The pie-chart shown here illustrates the distribution of the 366 enriched proteins identified with the X-ChIP method in regular HEK293 TwinkleFLAG and measured in HEK293 TwinkleFLAG ρ° in the following classes: not detected (absent), 95 proteins; ≥2 fold decrease, 163 proteins; no change, 100 proteins or ≥2 fold increase, 8 proteins(see also <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0116726#pone.0116726.s004" target="_blank">S3 Table</a>). …”

Effect of CART on the number of TH-labeled neuronal cells in the SN-PC. by Peizhong Mao (189608)

“…Administration of CART reversed the MPTP-induced decrease in TH-labeled cells. <b>B.</b>) CART peptide (50 ng/mouse, IP) or vehicle (0.1 ml/10 grams, IP) was injected one day prior to the start of sub-acute administration of either MPTP (7 mg/kg/d) or vehicle for 7 days. …”

Supplementary Material for: Sensitivity and Specificity of Urinary Neutrophil Gelatinase-Associated Lipocalin and Kidney Injury Molecule-1 for the Diagnosis of Renal Cell Carcinoma by Morrissey J.J. (4128844)

Endostatin inhibits VEGF-A induced osteoclastic bone resorption -0 by Annina Sipola (20229)

TGFβ induces <i>SOST</i> expression through Smad3. by Jacqueline Nguyen (290539)

Electroretinogram recordings of <i>mglur6b</i>-depleted zebrafish larvae. by Ying-Yu Huang (171396)

Contribution of anti-gp120 antibodies to the overall neutralizing activity of HIV+ plasmas. by Iliyana Mikell (120166)

“…<p>(A) Log10 decrease in neutralizing activity caused by the elimination of anti-gp120 antibodies, and (B) Log10 decrease in neutralizing activity of plasmas in the presence of D368R. …”

<i>In vitro</i> culture system of immature oocytes from preantral follicles. by Zhi-Peng Zhang (149108)

“…PAGCs were cultured as described in M&M, denuded oocytes were divided into four groups: oocytes cocultured with PAGCs in the presence (DOs+PAGCs+ActA) or absence of 100 ng/ml ActA (DOs+PAGCs) for 6–7 days, and oocytes cultured alone in the presence (DOs+ActA) or absence of ActA (DOs) for the same period. …”

DataSheet1.DOCX by Alexander H. Turaihi (4995452)

“…In these experiments insulin (10.0 nM) increased diameter in the presence of IRS2^+/+ PVAT (17 ± 4.8, p = 0.014), yet induced a 10 ± 7.6% decrease in diameter in the presence of IRS2^−/− PVAT. …”

Homolog pairing and sister chromatid cohesion in interphase remain unaffected genome-wide after knockdown of Rad21. by T. Niroshini Senaratne (3067776)

“…A simple separation of sister chromatids would be expected to cause a decrease in the percentage of nuclei with a single FISH signal, or an increase in the area of FISH signals; we observed neither (see main text for details).…”

DataSheet_2_In Patients With Obesity, the Number of Adipose Tissue Mast Cells Is Significantly Lower in Subjects With Type 2 Diabetes.docx by David Lopez-Perez (10842069)

“…Since mast cell progenitors cannot arrive at WAT, the amount of WAT mast cells depends on how the new microenvironment affects progenitor and differentiated mast cells. Here, we employed a flow cytometry-based approach to analyze the number of mast cells from omental white adipose tissue (o-WAT) and subcutaneous white adipose tissue (s-WAT) in a cohort of 100 patients with obesity. …”

<i>T. cruzi</i> infection alters host blood lipid profile and cardiac cholesterol level. by Fnu Nagajyothi (37087)

“…Results are presented as % difference compared to uninfected RD fed mice at day 0 post infection(d0 pi = 100%). (<b>c</b>) Analysis of total cholesterol (TC) levels in the RD fed mice showed a significant decrease (p≤0.005) even at 15 dpi compared to uninfected mice (n = 5). …”

Revisiting aneuploidy profile of surgically retrieved spermatozoa by whole exome sequencing molecular karyotype by Stephanie Cheung (254096)

“…The assessment by FISH evidenced 2.8% chromosomal defects in the ejaculated and 1.2% in testicular biopsies while by NGS became 8.4% and 1.3% (<i>P</i> = 0.02), respectively. Interestingly, we evidenced a pregnancy rate of 0% with ejaculated while 100% with the testicular spermatozoa in this latter group. …”

Data_Sheet_1_Increase of Albinistic Hosts Caused by Gut Parasites Promotes Self-Transmission.docx by Shuqian Tan (5494841)

“…In addition, there was a decrease in phenol oxidase activity and the expression of henna and pale, which are involved in the synthesis of cuticle melanin, decreased. …”

Enhanced megakaryopoiesis and thrombopoieisis after DT-mediated MK ablation. by Catherine Angénieux (145933)

“…<p>F1 iDTR x PF4-Cre mice received 100 ng/day DT or saline for 4 days (first injection on day 1). …”

Aa EVs and RNA cargo activate TLR signaling. by Jae Yeong Ha (9676175)

“…LPS (100 ng/ml) for TLR4, and R848 (1 μg/ml) for TLR7/8 were used as positive controls (PC) for each cell line. …”

Nigral TH protein loss in aging. by Michael F. Salvatore (255748)

The DEDI-domain of caspase 8 is critical for its interaction with Bcl2. by Mahbuba Rahman (198499)

“…Cells were transiently transfected with wild-type caspase 8 (Csp8), mutants (DEDIm, PBm, and DEDIIm), or empty-vector (EV, control) for 48 h, followed by exposure to 100 ng/mL rSPARC for 48 h, and treated with 0 (▪) or 500 µM (□)5-FU for an additional 24 h. …”

Image_1_Different Renal Function Patterns in Patients With Acute Heart Failure: Relationship With Outcome and Congestion.jpeg by Alberto Palazzuoli (12203753)

“…The primary outcome was the combined endpoint of 180 days including all causes of mortality and re-hospitalization.</p>Results<p>We recruited 467 subjects with a mean congestion score of 3.5±1.08 and a median creatinine value of 1.28 (1.00–1.70) mg/dl, eGFR 50 (37–65) ml/min/m² and NTpro B-type natriuretic peptide (BNP) 7,000 (4,200–11,700) pg/ml. …”