Hormone-sensitive BCa cells (MCF-7) comprise 3 subpopulations, distinguished by ER-α46 expression levels. by John J. Kim (11191609)

“…<b>C</b> Scatter plots of ER-α66 and ER-α46 expression levels in individual MCF-7 cells (*p = 0.03, ***p < 0.0001, n_{ER-α66_only} = 329 cells, n_both = 26 cells). Red lines represent mean values. <b>D</b> Top: scatter plots indicate that mean ER-α66 expression level is decreased in ER-α66⁺ subpopulation by TAM (***p < 0.0001, n_neg = 604, n_TAM = 227). …”

supplementary figure: Osimertinib inhibits the MYLK4-mediated phosphorylation of CDKAL1 to suppress stemness and chemoresistance in rhabdomyosarcoma by Takuto Itano (16830105)

“…<p dir="ltr">Supplementary Figure: Identification of osimertinib as an inhibitor of the MYLK4–CDKAL1–SALL2 axis a (left): RT‒qPCR and immunoblotting of RD cells treated with 40 ng/mL epidermal growth factor (EGF) and 2.5 µM osimertinib for 24 h revealed that osimertinib inhibits SALL2 expression in a translation-dependent manner. …”

Data_Sheet_1_Neural mechanisms of expert persuasion on willingness to pay for sugar.pdf by Ioannis Ntoumanis (11904629)

“…We recently showed that a healthy eating call by a health expert can significantly decrease the willingness to pay (WTP) for sugar-containing food. …”

MCF-DCIS clusters co-cultured with 3D HMF and with 2D HMF. by Kyung Eun Sung (467005)

“…<p>(A) MCF-DCIS clusters (red and outlines) co-cultured with 3D HMF and neutralizing HGF antibody at 0.5 μg/ml (3D HMF-HGF). …”

Actin polymerization lead to YAP de-phosphorylation and nuclear localization. by Pradeep Reddy (371909)

“…<p>A. The levels of pYAP are decreased after treatment with jasplakinolide. …”

Phospholamban Modulates the Functional Coupling between Nucleotide Domains in Ca-ATPase Oligomeric Complexes in Cardiac Sarcoplasmic Reticulum by Linda T. L. Chen (2384860)

“…Accompanying the phosphorylation of PLB, neighboring Ca-ATPase polypeptide chains exhibit a 4 ± 2 Å decrease in the proximity between FITC sites within the N-domain and a 9 ± 3 Å increase in the proximity between IAF sites within P-domains. …”

WIKI4 inhibits the functional outcomes of Wnt/ß-catenin signaling. by Richard G. James (114424)

“…(<b>C</b>) Treatment with WIKI4 prevents the decrease in co-expression of markers of undifferentiated hESCs following Wnt3A stimulus. hESCs were stimulated with the indicated treatments and expression of GCTM2 and CD9 was assessed by flow cytometry following six days of treatment. …”

Effects of the activation and inhibition of NOTCH signalling on spinal cord progenitor cell proliferation and neuronal generation. by Barbara Hämmerle (36261)

“…Higher magnification of a single optical section (5 µm) of the boxed region of F showing two double labelled cells. …”

Proteomic Biomarkers for Ageing the Mosquito <em>Aedes aegypti</em> to Determine Risk of Pathogen Transmission by Leon E. Hugo (252728)

“…Using the 2-D Difference Gel Electrophoresis (2-D DIGE) procedure, we investigated the abundance of up to 898 proteins from the Yellow Fever and dengue virus vector, <i>Aedes aegypti</i>, during ageing. By applying a mixed-effects model of protein expression, we identified five common patterns of abundance change during ageing and demonstrated an age-related decrease in variance for four of these. …”

Significantly enriched pathways after infection by EV-D94 or EV-D68 in respiratory and intestinal tissues. by Ines Cordeiro Filipe (5849144)

“…<p><b>A)</b>. Genes with average log2 fold change increase/decrease of 0.5 versus the mock were considered for pathway analysis. …”

Solution X-ray Absorption Fine Structure Study of the Eu²⁺ and Sr²⁺ Ions:  Unexpected Solvent and Metal Ion Dependencies of the Solvation Numbers by Gilles Moreau (3042738)

“…For both Eu²⁺ and Sr²⁺ ions, a decrease in coordination number (<i>N</i>) and metal-to-solvent distances was found along the increasingly solvating MeCN < H₂O ≪ DMF < DMSO solvent series:  for strontium, <i>N</i> = 8 with [Sr(MeCN)₈]²⁺ (2.665(6) Å) and [Sr(H₂O)₈]²⁺ (2.600(3) Å) and <i>N</i> = 7 with [Sr(DMF)₇]²⁺ (2.555(5) Å) and [Sr(DMSO)₇]²⁺ (2.540(7) Å); for europium(II), <i>N</i> = 8 with [Eu(MeCN)₈]²⁺ (2.640(4) Å), <i>N</i> = 7 with [Eu(H₂O)₇]²⁺ (2.584(5) Å), and <i>N</i> = 6 with [Eu(DMF)₆]²⁺ (2.541(3) Å) and by extrapolation [Eu(DMSO)₆]²⁺ (2.525 Å). …”

Phospholamban Modulates the Functional Coupling between Nucleotide Domains in Ca-ATPase Oligomeric Complexes in Cardiac Sarcoplasmic Reticulum by Linda T. L. Chen (2384860)

“…Accompanying the phosphorylation of PLB, neighboring Ca-ATPase polypeptide chains exhibit a 4 ± 2 Å decrease in the proximity between FITC sites within the N-domain and a 9 ± 3 Å increase in the proximity between IAF sites within P-domains. …”

Global divergent responses of soil heterotrophic respiration to nitrogen deposition by Peng Guo (13816147)

“…Δ<i>R</i>_H significantly increased in alkaline soils (pH > 7.5) but decreased in acidic soils (pH < 5.5). Furthermore, Δ<i>R</i>_H significantly increased in soils with high total organic carbon (TOC > 15 g/kg) or low available N contents (NH4+ < 19 mg/kg or NO3− < 15 mg/kg), but decreased in soils with high total N (TN > 11 g/kg). …”

Image_2_Activation of Invariant Natural Killer T Cells by α-Galactosylceramide Attenuates the Development of Angiotensin II-Mediated Abdominal Aortic Aneurysm in Obese ob/ob Mice.J... by Akimichi Saito (10772010)

“…Ob/ob mice were administered angiotensin II (AngII, 1,000 ng/kg/min) or phosphate-buffered saline (PBS) by osmotic minipumps for 4 weeks and further divided into 2 groups; α-galactosylceramide (αGC; PBS-αGC; n = 5 and AngII-αGC; n = 12), which specifically activates iNKT cells, and PBS (PBS-PBS; n = 10, and AngII-PBS; n = 6). …”

Table_1_Activation of Invariant Natural Killer T Cells by α-Galactosylceramide Attenuates the Development of Angiotensin II-Mediated Abdominal Aortic Aneurysm in Obese ob/ob Mice.p... by Akimichi Saito (10772010)

“…Ob/ob mice were administered angiotensin II (AngII, 1,000 ng/kg/min) or phosphate-buffered saline (PBS) by osmotic minipumps for 4 weeks and further divided into 2 groups; α-galactosylceramide (αGC; PBS-αGC; n = 5 and AngII-αGC; n = 12), which specifically activates iNKT cells, and PBS (PBS-PBS; n = 10, and AngII-PBS; n = 6). …”

Image_1_Activation of Invariant Natural Killer T Cells by α-Galactosylceramide Attenuates the Development of Angiotensin II-Mediated Abdominal Aortic Aneurysm in Obese ob/ob Mice.J... by Akimichi Saito (10772010)

“…Ob/ob mice were administered angiotensin II (AngII, 1,000 ng/kg/min) or phosphate-buffered saline (PBS) by osmotic minipumps for 4 weeks and further divided into 2 groups; α-galactosylceramide (αGC; PBS-αGC; n = 5 and AngII-αGC; n = 12), which specifically activates iNKT cells, and PBS (PBS-PBS; n = 10, and AngII-PBS; n = 6). …”

Image_1_Chemerin and PEDF Are Metaflammation-Related Biomarkers of Disease Activity and Obesity in Rheumatoid Arthritis.pdf by Barbara Tolusso (146649)

“…Moreover, after low-calories diet, RA with low-moderate disease activity reaching BMI reduction ≥5% (62.6%) at 6 months had significant decrease of PEDF (p < 0.05) and Chemerin (p < 0.05) plasma values, in parallel with the improvement in disease activity.…”

Table1_Effects of shading on morphology, photosynthesis characteristics, and yield of different shade-tolerant peanut varieties at the flowering stage.docx by Jing Wang (6206297)

“…Shade stress led to decreased dry-matter accumulation, reduced weight of 100 fruits and kernels, and a significant decline in yield in the shade-sensitive cultivars. …”

Minimally Invasive Cardiac Surgery versus Sternotomy - Pain Investigation by Juliana Fernandes Silva (7292450)

“…In addition, patients subjected to MI procedure had a significant decrease in pain intensity from the third to the seventh PO days (p = 0.001). …”

DataSheet1_The interplay of common genetic variants NRG1 rs2439302 and RET rs2435357 increases the risk of developing Hirschsprung’s disease.PDF by Shuiqing Chi (10298891)

“…NRG1 and RET double mutants caused the most severe reduction in enteric neuron numbers than NRG1 single mutant or RET single mutant in the hindgut of zebrafish. SHSY-5Y cells and IPSCs with rs2439302 GG/rs2435357 TT genotype exhibited a decreased proliferative, migration, and differentiative capacity. …”