Discovery of the Triazolo[1,5‑<i>a</i>]Pyrimidine-Based Derivative WS-898 as a Highly Efficacious and Orally Bioavailable ABCB1 Inhibitor Capable of Overcoming Multidrug Resistance... حسب Shuai Wang (109515)

"…Here, we reported our medicinal chemistry efforts that led to the discovery of the triazolo­[1,5-<i>a</i>]­pyrimidine derivative <b>WS-898</b> as a highly effective ABCB1 inhibitor capable of reversing paclitaxel (PTX) resistance in drug-resistant SW620/Ad300, KB-C2, and HEK293/ABCB1 cells (IC₅₀ = 5.0, 3.67, and 3.68 nM, respectively), more potent than verapamil and zosuquidar. …"

Discovery of the Triazolo[1,5‑<i>a</i>]Pyrimidine-Based Derivative WS-898 as a Highly Efficacious and Orally Bioavailable ABCB1 Inhibitor Capable of Overcoming Multidrug Resistance... حسب Shuai Wang (109515)

"…Here, we reported our medicinal chemistry efforts that led to the discovery of the triazolo­[1,5-<i>a</i>]­pyrimidine derivative <b>WS-898</b> as a highly effective ABCB1 inhibitor capable of reversing paclitaxel (PTX) resistance in drug-resistant SW620/Ad300, KB-C2, and HEK293/ABCB1 cells (IC₅₀ = 5.0, 3.67, and 3.68 nM, respectively), more potent than verapamil and zosuquidar. …"

Absorption spectra of 12.5 mM sodium chlorite solutions with different concentrations of sulfuric acid. حسب Ayuta Kishimoto (16814662)

Fibrin concentration of 10,000 simulations compared to experimental data of blood clotting over collagen/ TF under venous flow rate. حسب Jason Chen (15937)

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Fluorescence ratio imaging of mouse blastocysts based on 340 nm and 380 nm excitation, with bright-field images. حسب Ayaka Fujishima (21221913)

Changes of fibrotic proteins in rat peritoneum. حسب Yangyang Yin (14323701)

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Changes of miR-132-3p in peritoneal dialysis patients with different duration. حسب Yangyang Yin (14323701)

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This is the raw data of IHC-1 in Rat. حسب Yangyang Yin (14323701)

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Regulation of TGF-<i>β</i>1 protein expression by MiR-132-3p was verified using WB. حسب Yangyang Yin (14323701)

الموضوعات:

The effect of MiR-132-3p on protein expression in TGF-<i>β</i>1/Smad2/3 signaling pathway was observed by immunofluorescence. حسب Yangyang Yin (14323701)

الموضوعات:

Sequences of the primers for q-PCR. حسب Yangyang Yin (14323701)

الموضوعات:

Changes of peritoneal structure and function in rats. حسب Yangyang Yin (14323701)

الموضوعات:

Changes of miR-132-3p in rat peritoneum. حسب Yangyang Yin (14323701)

الموضوعات:

Measurement of mitochondrial superoxide anion production in HL-1 cells exposed for 12 or 72h to LG, NG, HG or IHG. حسب Patrick Mordel (17020879)

Transient convection-diffusion of thrombin into and out of a fibrin domain exposed to venous flow. حسب Jason Chen (15937)

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Detection of the Challenging mutations at 1% VAF and 50 ng DNA input. حسب Lizhi Yu (12476136)

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Global Land Use Change Impacts on Soil Nitrogen Availability and Environmental Losses حسب Jing Wang (6206297)

"…However, how global land use changes impact soil N supply and potential N loss remains elusive. By compiling a global data set of 1,782 paired observations from 185 publications, we show that land use conversion from natural to managed ecosystems significantly reduced NNM by 7.5% (−11.5, −2.8%) and increased NN by 150% (86, 194%), indicating decreasing N availability while increasing potential N loss through denitrification and nitrate leaching. …"

Waterborne Tebuconazole Exposure Induces Male-Biased Sex Differentiation in Zebrafish (Danio rerio) Larvae via Aromatase Inhibition حسب Kun Qiao (6017606)

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Waterborne Tebuconazole Exposure Induces Male-Biased Sex Differentiation in Zebrafish (Danio rerio) Larvae via Aromatase Inhibition حسب Kun Qiao (6017606)

الموضوعات:

Waterborne Tebuconazole Exposure Induces Male-Biased Sex Differentiation in Zebrafish (Danio rerio) Larvae via Aromatase Inhibition حسب Kun Qiao (6017606)

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