Discovery of the Triazolo[1,5‑<i>a</i>]Pyrimidine-Based Derivative WS-898 as a Highly Efficacious and Orally Bioavailable ABCB1 Inhibitor Capable of Overcoming Multidrug Resistance... حسب Shuai Wang (109515)

"…Targeting P-glycoprotein (ABCB1 or P-gp) has been recognized as a promising strategy to overcome multidrug resistance. Here, we reported our medicinal chemistry efforts that led to the discovery of the triazolo­[1,5-<i>a</i>]­pyrimidine derivative <b>WS-898</b> as a highly effective ABCB1 inhibitor capable of reversing paclitaxel (PTX) resistance in drug-resistant SW620/Ad300, KB-C2, and HEK293/ABCB1 cells (IC₅₀ = 5.0, 3.67, and 3.68 nM, respectively), more potent than verapamil and zosuquidar. …"

Discovery of the Triazolo[1,5‑<i>a</i>]Pyrimidine-Based Derivative WS-898 as a Highly Efficacious and Orally Bioavailable ABCB1 Inhibitor Capable of Overcoming Multidrug Resistance... حسب Shuai Wang (109515)

"…Targeting P-glycoprotein (ABCB1 or P-gp) has been recognized as a promising strategy to overcome multidrug resistance. Here, we reported our medicinal chemistry efforts that led to the discovery of the triazolo­[1,5-<i>a</i>]­pyrimidine derivative <b>WS-898</b> as a highly effective ABCB1 inhibitor capable of reversing paclitaxel (PTX) resistance in drug-resistant SW620/Ad300, KB-C2, and HEK293/ABCB1 cells (IC₅₀ = 5.0, 3.67, and 3.68 nM, respectively), more potent than verapamil and zosuquidar. …"

Simulation results of dichromatic mirror across the 400 - 700 nm spectral range. حسب Ngoc-Hai Vu (22290844)

High resolution structures visible with the 25 nm zone plate objective. حسب Kamal L. Nahas (13014698)

"…<p>139 CryoSXT tomograms were recorded from 107 cells using a 25 nm zone plate objective and several structures that were unrelated to HSV-1 infection were observed, including some that were not visible using the 40 nm zone plate objective. …"

Preliminary search for price decreases for the period 01 Jan. 2021–14 Jun. 2022. حسب Jevgeni Tarassov (13889285)

Baseline level biochemical and circulating biomarkers in study subjects. حسب Jaskiran Kaur (160829)

Change in serum levels of vitamin D and angiogenic marker at 16 weeks follow-up. حسب Jaskiran Kaur (160829)

Dasatinib plasma pharmacokinetics in male and female VD₃ sufficient and deficient mice after a single oral gavage of 10 mg/kg dasatinib. حسب Kavya Annu (11587215)

Recombination of Autodissociated Water Ions in a Nanoscale Pure Water Droplet حسب Soonho Kwon (1402972)

"…We found that the self-diffusion of water dramatically decreases in droplets with a diameter below 2.2 nm. …"

Recombination of Autodissociated Water Ions in a Nanoscale Pure Water Droplet حسب Soonho Kwon (1402972)

"…We found that the self-diffusion of water dramatically decreases in droplets with a diameter below 2.2 nm. …"

Recombination of Autodissociated Water Ions in a Nanoscale Pure Water Droplet حسب Soonho Kwon (1402972)

"…We found that the self-diffusion of water dramatically decreases in droplets with a diameter below 2.2 nm. …"

Recombination of Autodissociated Water Ions in a Nanoscale Pure Water Droplet حسب Soonho Kwon (1402972)

"…We found that the self-diffusion of water dramatically decreases in droplets with a diameter below 2.2 nm. …"

Recombination of Autodissociated Water Ions in a Nanoscale Pure Water Droplet حسب Soonho Kwon (1402972)

"…We found that the self-diffusion of water dramatically decreases in droplets with a diameter below 2.2 nm. …"

Recombination of Autodissociated Water Ions in a Nanoscale Pure Water Droplet حسب Soonho Kwon (1402972)

"…We found that the self-diffusion of water dramatically decreases in droplets with a diameter below 2.2 nm. …"

Recombination of Autodissociated Water Ions in a Nanoscale Pure Water Droplet حسب Soonho Kwon (1402972)

"…We found that the self-diffusion of water dramatically decreases in droplets with a diameter below 2.2 nm. …"

Recombination of Autodissociated Water Ions in a Nanoscale Pure Water Droplet حسب Soonho Kwon (1402972)

"…We found that the self-diffusion of water dramatically decreases in droplets with a diameter below 2.2 nm. …"

Recombination of Autodissociated Water Ions in a Nanoscale Pure Water Droplet حسب Soonho Kwon (1402972)

"…We found that the self-diffusion of water dramatically decreases in droplets with a diameter below 2.2 nm. …"

Recombination of Autodissociated Water Ions in a Nanoscale Pure Water Droplet حسب Soonho Kwon (1402972)

"…We found that the self-diffusion of water dramatically decreases in droplets with a diameter below 2.2 nm. …"

Recombination of Autodissociated Water Ions in a Nanoscale Pure Water Droplet حسب Soonho Kwon (1402972)

"…We found that the self-diffusion of water dramatically decreases in droplets with a diameter below 2.2 nm. …"

Recombination of Autodissociated Water Ions in a Nanoscale Pure Water Droplet حسب Soonho Kwon (1402972)

"…We found that the self-diffusion of water dramatically decreases in droplets with a diameter below 2.2 nm. …"