Ticagrelor treatment, but not clopidogrel treatment, induces the praroxonase-1 (PON1) message, increases tissue and serum PON1 protein, and mitigates atherosclerosis. by Hasseri Halim (6883436)

“…<p>Abbreviations: CTL, control; CLO, clopidogrel; TIC, ticagrelor; RNA-Seq, RNA sequencing using next generation sequencing; PON1, paraoxonase 1; A.U., arbitrary unit; N = 5 per group; Error bars, means ± SD, statistical analyses performed using one-way ANOVA test with Fisher’s multiple comparisons; <i>NS</i>, not statistically significant; *, P < 0.05; **, P < 0.01 <i>(See also <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0218934#pone.0218934.s005" target="_blank">S5 Fig</a>).…”

SPARC-mediated SLUG expression and promotion of melanoma cell migration is PI3K/AKT dependent. by Nina Fenouille (149658)

“…SPARC cells were treated with DMSO or 10 mmol/L AIIV, LY294002 or PLX4720 for 3 hours. …”

Analyses of AtT-20 cell cycle by flow cytometry under lycopene (Lycop) or beta-carotene (beta-carot) stimulation. by Natália F. Haddad (410503)

“…No significant differences between cell cycle phases were observed when AtT-20 cells were treated with 5 and 10 µM lycopene for 48 h (<b>A</b>), but after 96 h (<b>B</b>), cells in both concentrations showed an increase in G0/G1 and a decrease in S and G2/M phases. …”

Effect of CPP-ACP on enamel eroded extrinsically: in vitro study by Iandara de Lima SCARDINI (6135746)

“…The paste in G4 did not promote an increase in hardness values nor a decrease in roughness values. Conclusion: It was concluded that CPP-ACP was unable to remineralize enamel subjected to extrinsic erosion, being ineffective in preventing erosion of enamel and in the remineralization of the eroded enamel.…”

Table_1_Ideal Cardiovascular Health in the Oldest-Old and Centenarians and Its Association With Disability and Health-Related Quality of Life.docx by Miao Liu (148274)

“…The EQ VAS and EQ-5D score show an increasing trend along with the increasing number of ICH indicators (p < 0.05). …”

Table1_Neuroprotective Effects of Oligosaccharides From Periplaneta Americana on Parkinson’s Disease Models In Vitro and In Vivo.DOCX by Miao-Miao Liu (347989)

“…The data demonstrated that OPA significantly reversed the MPP⁺-induced decrease in SH-SY5Y cell viability, reduced the proportion of apoptotic cells, and protected SH-SY5Y cells from apoptosis in a dose-dependent manner by regulating the expression of apoptosis-related genes. …”

Datasheet1_Trends in hypertension and hypertension treatment in primary care in general practices in Germany between 2013 and 2022.pdf by Karel Kostev (2577346)

“…After adjusting for covariates, there was a significant decrease in the number of patients diagnosed with hypertension (beta coefficient = −7.91, p-value < 0.001) and treated with any antihypertensive drug per practice per year between 2013 and 2022 (beta coefficient = −5.40, p-value < 0.001).…”

Synbiotics for Broiler Chickens—<i>In Vitro</i> Design and Evaluation of the Influence on Host and Selected Microbiota Populations following <i>In Ovo</i> Delivery - Fig 2 by Aleksandra Dunislawska (3611762)

“…The highest dose that did not decrease hatchability (10⁵ cfu egg^-1 of prebiotic and 2 mg egg of probiotic) was selected for the field trial. …”

Ultrastructure and immunofluorescent staining of the macrodactylous enlarged nerve (MEN) and normal digital nerve (NDN) tissue. by Xi Yang (112884)

“…(B) MEN tissue showed a significant decrease in the number of myelinated nerve fibers compared with those in NDN tissue (scale bars, 5.0 nm) and collagen density of the nerve fibers was distinctly increased (B, white arrows) (C) The diameter of the myelinated fiber was apparently reduced in the new regenerative nerve structures (C, yellow arrows), which was found in Berrettini anastomosis (BA) (scale bars, 5.0 nm). …”

Temporal distribution of scFv-h3D6 through the extra- and intracellular brain compartments. by Gisela Esquerda-Canals (4329706)

“…<p>(A) Extracellular (continuous line, top) and intracellular (dashed line, bottom) scFv-h3D6 levels are represented over time p.i.: 0h (for vehicle-injected mice), 1h, 5h, 10h, 1 day, 2 days, 5 days, and 8 days. …”

The transcriptional activities of FASN in SKBR3, MCF-7and MCF-7/HER2 breast cancer cells treated with mTOR inhibitor rapamycin. by Chen Yan (478322)

“…<p>A, The transcriptional activities of FASN promoter in the three cells were all inhibited treated with rapamycin (2.5 nmol/L, 4 h) and the inhibition effect showed more significant in MCF/HER2 cell lines than in MCF-7 and SKBR3 cell lines (p<0.05). …”

Random forest identified stop codon identity, P-site amino acid identity, and 3’-UTR length as factors critical in readthrough efficiency prediction. by Kotchaphorn Mangkalaphiban (9767180)

“…<p><b>A.</b> Performance metric for random forest regression displaying average Normalized Root Mean Squared Error (NRMSE) ± standard deviation across 5-fold cross-validation. …”

Effects of lycopene on ER stress inducer (thapsigargin, TG)-induced changes in neonatal cardiomyocytes. by Jiqian Xu (785333)

“…The total proteins of cardiomyocytes were extracted and the protein expression levels of Bip/GRP78 and GADD153 were detected by western blot. (A) TG evoked a dose-dependent decrease in the viability of neonatal cardiomyocytes. …”

Combination of cetuximab and trametinib was more effective in the partially responsive group ex vivo. by Takahiro Tashiro (827031)

“…E, Western blots of lysates from the reconstituted spheroids treated with or without 100 nM cetuximab, 5 nM trametinib, or a combination of 100 nM cetuximab and 5 nM trametinib for 2 h with or without stimulation with 10 ng/ml EGF for 15 min.…”

<i>In vitro</i> reductase activity with furfural and HMF as substrates in crude cell extracts from the strains MD4, MD4.1 and GVM1, the latter two each containing one copy of <i>AS... by Gert Vanmarcke (10580115)

“…For each condition, at least three technical repeats were used. (A) 2.5 mM and 5 mM furfural with NADH, (B) 5 mM furfural with NADPH, (C) 10 mM HMF with NADPH. …”

Fig 2 - by Stuart Meier (29078)

“…<p>GO annotations and KEGG pathways first enriched at (A) 13–18 and 7–12 months before diagnosis and (B) 1–6 months before diagnosis. …”

DataSheet1_Neuroprotective Effects of Oligosaccharides From Periplaneta Americana on Parkinson’s Disease Models In Vitro and In Vivo.zip by Miao-Miao Liu (347989)

“…The data demonstrated that OPA significantly reversed the MPP⁺-induced decrease in SH-SY5Y cell viability, reduced the proportion of apoptotic cells, and protected SH-SY5Y cells from apoptosis in a dose-dependent manner by regulating the expression of apoptosis-related genes. …”

CLINICAL AND RADIOLOGICAL OUTCOMES OF THE NEUROMUSCULAR SCOLIOSIS TREATMENT WITH S2-ALAR-ILIAC SCREW BY INTRAOPERATIVE NAVIGATION by Alex Oliveira de Araújo (13902391)

“…The average preoperative pelvic obliquity was 27.9°± 10.9, with a correction rate of 66.1% ± 27.6, being 8.2° ± 5.4 at the end of surgery and 9 .4°± 7.0 at the end of the follow-up. …”

Synaptic Brp deficit in <i>srpk79D</i> mutants. by Ervin L. Johnson III (259396)

“…Scale bar indicates 10 µm. Significance is indicated according to the following: *** = <i>p</i><0.001 and ns = not significant; Student <i>t</i>-test. …”

Continuous mass spectrometry assay for proDer p 3 maturation by Der p 1. by Marie-Eve Dumez (461300)

“…<p>Electrospray mass spectra (positive ion mode) for 16 µM proDer p 3 activation by 0.16 µM Der p 1 in 25 mM ammonium acetate, pH 7.4, containing 1 mM DTT, obtained after 5 min (<b>A</b>) and 40 min (<b>B</b>). ProD, D and prop refer to proDer p 3, Der p 3 and propeptide, respectively. …”