Showing 161 - 180 results of 148,020 for search '(( 10 we decrease ) OR ( 10 ((((ng decrease) OR (nn decrease))) OR (a decrease)) ))', query time: 1.02s Refine Results
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    Structure-Guided Design, Synthesis, and Biological Evaluation of (2-(1<i>H</i>‑Indol-3-yl)‑1<i>H</i>‑imidazol-4-yl)(3,4,5-trimethoxyphenyl) Methanone (ABI-231) Analogues Targeting... by Qinghui Wang (2042065)

    Published 2019
    “…In vitro, biological studies showed that new ABI-231 analogues disrupt tubulin polymerization, promote microtubule fragmentation, and inhibit cancer cell migration. In vivo, analogue <b>10bb</b> not only significantly inhibits primary tumor growth and decreases tumor metastasis in melanoma xenograft models but also shows a significant ability to overcome paclitaxel resistance in a taxane-resistant PC-3/TxR model. …”
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