Data_Sheet_1_Screening effects of HCN channel blockers on sleep/wake behavior in zebrafish.PDF by Fusun Doldur-Balli (3459110)

“…Results of interest included shorter latency to daytime sleep at 0.1 μM dose of Ivabradine (ANOVA, p: 0.02), moderate reduction in average activity at 30 μM dose of Zatebradine Hydrochloride (ANOVA, p: 0.024) in daytime, and increased nighttime sleep at 4.5 μM dose of ZD7288 (ANOVA, p: 0.036). Taken together, shorter latency to daytime sleep, decrease in daytime activity and increased nighttime sleep indicate that different HCN channel antagonists affected different parameters of sleep and activity.…”

Multiaction Platinum(IV) Prodrug Containing Thymidylate Synthase Inhibitor and Metabolic Modifier against Triple-Negative Breast Cancer by Nafees Muhammad (5641151)

“…Cellular uptake and distribution studies reveal that <b>PFL</b> mainly accumulates in mitochondria. As a result, <b>PFL</b> disrupts the mitochondrial ultrastructure and induces significant alterations in the mitochondrial membrane potential, which further leads to an increase in production of reactive oxygen species (ROS) and a decrease in ATP synthesis in MDA-MB-231 TNBCs. …”

Table_2_Comparison Analysis of Different DNA Extraction Methods on Suitability for Long-Read Metagenomic Nanopore Sequencing.docx by Lei Zhang (38117)

“…Compared with the control method, the enzymatic-based method increased the average length of microbial reads by a median of 2.1-fold [Inter Quartile Range (IQR), 1.7–2.5; maximum, 4.8) in 18 of the 20 samples and the mapped reads proportion of specific species by a median of 11.8-fold (Inter Quartile Range (IQR), 6.9–32.2; maximum, 79.27]. …”

Acute and chronic effects of LPS on left ventricular (LV) size and function by echocardiography. by Wilbur Y. W. Lew (400836)

“…Panel B: LV fractional shortening, heart rate, LV internal diameter in diastole (LVIDd), and LV mass measured after 2 months of weekly i.p. injections of saline (n = 11), LPS 10 mg/kg (n = 8) and LPS 20 mg/kg (n = 12), and after 3 months of weekly i.p. injections of saline (n = 13) or LPS 20 mg/kg (n = 5). There were a few minor changes with LPS 20 mg/kg (*P<0.05 compared with control), but no significant decrease in LV function, LV dilation, or change in LV mass.…”

Image_1_Liver-Specific Knockdown of Class IIa HDACs Has Limited Efficacy on Glucose Metabolism but Entails Severe Organ Side Effects in Mice.TIF by Nicole Ziegler (6893297)

“…The triple knockdown resulted in a statistically significant decrease of gluconeogenic gene expression in murine and human hepatocyte cell models. …”

Ethanol extract of Cissampelos sympodialis ameliorates lung tissue damage in streptozotocin-induced diabetic rats by Tessio David de Medeiros (8588649)

“…<div><p>Diabetes Mellitus (DM) is a metabolic syndrome characterized by hyperglycemia. …”

Table_1_Liver-Specific Knockdown of Class IIa HDACs Has Limited Efficacy on Glucose Metabolism but Entails Severe Organ Side Effects in Mice.docx by Nicole Ziegler (6893297)

“…The triple knockdown resulted in a statistically significant decrease of gluconeogenic gene expression in murine and human hepatocyte cell models. …”

Image_2_Liver-Specific Knockdown of Class IIa HDACs Has Limited Efficacy on Glucose Metabolism but Entails Severe Organ Side Effects in Mice.TIF by Nicole Ziegler (6893297)

“…The triple knockdown resulted in a statistically significant decrease of gluconeogenic gene expression in murine and human hepatocyte cell models. …”

Table_1_Fronto-parietal theta high-definition transcranial alternating current stimulation may modulate working memory under postural control conditions in young healthy adults.doc... by Yanwen Xiao (16972179)

“…</p>Results<p>Within the tACS group, we found a 5.3% significant decrease in working memory response time under the dual-task following tACS (t = −3.157, p = 0.005, Cohen’s d = 0.742); phase synchronization analysis revealed a significant increase in the phase locking value (PLV) of θ band between F3 and P3 after tACS (p = 0.010, Cohen’s d = 0.637). …”

Table_2_Fronto-parietal theta high-definition transcranial alternating current stimulation may modulate working memory under postural control conditions in young healthy adults.doc... by Yanwen Xiao (16972179)

“…</p>Results<p>Within the tACS group, we found a 5.3% significant decrease in working memory response time under the dual-task following tACS (t = −3.157, p = 0.005, Cohen’s d = 0.742); phase synchronization analysis revealed a significant increase in the phase locking value (PLV) of θ band between F3 and P3 after tACS (p = 0.010, Cohen’s d = 0.637). …”

Table_2_Fronto-parietal theta high-definition transcranial alternating current stimulation may modulate working memory under postural control conditions in young healthy adults.doc... by Yanwen Xiao (16972179)

“…</p>Results<p>Within the tACS group, we found a 5.3% significant decrease in working memory response time under the dual-task following tACS (t = −3.157, p = 0.005, Cohen’s d = 0.742); phase synchronization analysis revealed a significant increase in the phase locking value (PLV) of θ band between F3 and P3 after tACS (p = 0.010, Cohen’s d = 0.637). …”

Table_1_Fronto-parietal theta high-definition transcranial alternating current stimulation may modulate working memory under postural control conditions in young healthy adults.doc... by Yanwen Xiao (16972179)

“…</p>Results<p>Within the tACS group, we found a 5.3% significant decrease in working memory response time under the dual-task following tACS (t = −3.157, p = 0.005, Cohen’s d = 0.742); phase synchronization analysis revealed a significant increase in the phase locking value (PLV) of θ band between F3 and P3 after tACS (p = 0.010, Cohen’s d = 0.637). …”

Image_1_Modulation of low-dose ozone and LPS exposed acute mouse lung inflammation by IF1 mediated ATP hydrolysis inhibitor, BTB06584.tif by Pahul Singh (14781409)

“…Ozone and LPS exposure induced lung neutrophil and eosinophil recruitment as measured by respective peroxidase (MPO and EPX) assays, systemic leukopenia, increased levels of lung vascular neutrophil regulatory chemokines such as CXCL5, SDF-1, CXCL13 and a decrease in immune-regulatory chemokines such as BAL IL-10 and CCL27. …”

Image_2_Modulation of low-dose ozone and LPS exposed acute mouse lung inflammation by IF1 mediated ATP hydrolysis inhibitor, BTB06584.tif by Pahul Singh (14781409)

“…Ozone and LPS exposure induced lung neutrophil and eosinophil recruitment as measured by respective peroxidase (MPO and EPX) assays, systemic leukopenia, increased levels of lung vascular neutrophil regulatory chemokines such as CXCL5, SDF-1, CXCL13 and a decrease in immune-regulatory chemokines such as BAL IL-10 and CCL27. …”

Image_3_Modulation of low-dose ozone and LPS exposed acute mouse lung inflammation by IF1 mediated ATP hydrolysis inhibitor, BTB06584.tif by Pahul Singh (14781409)

“…Ozone and LPS exposure induced lung neutrophil and eosinophil recruitment as measured by respective peroxidase (MPO and EPX) assays, systemic leukopenia, increased levels of lung vascular neutrophil regulatory chemokines such as CXCL5, SDF-1, CXCL13 and a decrease in immune-regulatory chemokines such as BAL IL-10 and CCL27. …”

Data Sheet 1_Impact of primary production and net ecosystem metabolism on carbon and nutrient cycling at the land-sea interface.docx by Louise C. V. Rewrie (21016172)

“…When turbidity decreased in late spring (May), we observed elevated GPP rates, and highest GPP rates in summer (June-August), with seasonal averages of 613 ± 89 mg C m^-2 d^-1 in 2020 and 558 ± 77 mg C m^-2 d^-1 in 2021. …”

Sexual fate change of mutant XX germ cells was not accompanied by somatic sex reprogramming. by Quan Wu (444646)

“…Genes located right of the rightmost dotted red line show more than a 1.5-fold increase in DKO, and genes located left of the leftmost dotted red line show less than a 1.5-fold decrease in DKO compared with control ovaries. …”

Image_1_Shell accumulation on seabed due to suspended coastal oyster farming and effects on burrowing capacity of the polychaete Perinereis aibuhitensis.pdf by Yujie Cao (378830)

“…The amount of shell debris under oyster farm (6.0 ± 1.3 kg (dry weight (DW)) m^-2 or 130.0 ± 24.7 g (DW) kg^-1 dry sediment) was approximately two times that in a non-culture area (3.5 ± 0.9 kg (DW) m^-2 or 74.9 ± 10.5 g (DW) kg^-1 dry sediment). …”

image1_Intracolonic Mustard Oil Induces Visceral Pain in Mice by TRPA1-Dependent and -Independent Mechanisms: Role of Tissue Injury and P2X Receptors.pdf by Rafael Gonzalez-Cano (5157827)

“…<p>Both TRPA1 and purinergic P2X receptors have been proposed as potential targets for the treatment of visceral pain. We found that the intracolonic administration of a low dose mustard oil (0.5%), a well-known TRPA1 agonist, produced nociceptive responses and abdominal wall referred mechanical hyperalgesia, without inducing apparent tissue damage. …”

Mtu1-Mediated Thiouridine Formation of Mitochondrial tRNAs Is Required for Mitochondrial Translation and Is Involved in Reversible Infantile Liver Injury by Yong Wu (165587)

“…Genetic mutations in <i>MTU1</i> have been identified in RILF patients. MTU1 is a mitochondrial enzyme that catalyzes the 2-thiolation of 5-taurinomethyl-2-thiouridine (τm⁵s²U) found in the anticodon of a subset of mitochondrial tRNAs (mt-tRNAs). …”