Small Molecule Inhibitors of Activation-Induced Deaminase Decrease Class Switch Recombination in B Cells by Juan Alvarez-Gonzalez (10766032)

Blocking VIP-signaling decreased inflammation and necrosis in the liver and lung of mCMV-infected mice. by Jian-Ming Li (319425)

The G215S mutation decreases packaging of N and growth in primary differentiated human bronchial cells. by Hannah C. Kubinski (21213168)

LRP deficiency in MΦ's results in normal IFN-γ response but decreased IL-4. by Roman Covarrubias (602292)

Positive modulation of mGluR5 decreases spine density in the nucleus accumbens but not in the dorsal striatum. by Kellie S. Gross (3115299)

“…<p>(A) Twenty-four hours after systemic administration, CDPPB (5–10 mg/kg, <i>n</i> = 18 animals) decreased dendritic spine density and frequency of small head diameter spines (0.2 μm bin) compared to vehicle control (<i>n</i> = 8) in the nucleus accumbens core. …”

Pannexin-1 hemichannel blockade by probenecid decreases dendritic morphology and process dynamics of retinal microglia. by Aurora M. Fontainhas (232472)

“…<p><b><i>A</i></b>. Microglial morphologic parameters of dendritic tree area, total dendritic length, and branch point number were significantly decreased by the application of probenecid (1mM), an antagonist of pannexin-1 hemichannels; (n = 46 cells). …”

Critical Membrane Concentration and Mass-Balance Model to Identify Baseline Cytotoxicity of Hydrophobic and Ionizable Organic Chemicals in Mammalian Cell Lines by Jungeun Lee (142511)

“…Given the similarity of the bioassay-specific models, we propose a generalized baseline-model for adherent human cell lines: log­[1/IC_10,baseline (M)] = 1.23 + 4.97 × (1 – e^{–0.236 log <i>D</i>_lip/w}). …”

<i>patDp</i>/+ mice display decreased exploratory activity in the open field test. by Kota Tamada (235174)

KPn infection decreases the level of surface exposed phosphatidylserine (PS) and reduces efferocytosis of infected neutrophils. by Christopher N. Jondle (5807657)

REH2 knockdown decreased substrate loading and increased pausing during editing in 3010-MRB. by Bhaskara R. Madina (732552)

A Point Mutation in a lincRNA Upstream of <i>GDNF</i> Is Associated to a Canine Insensitivity to Pain: A Spontaneous Model for Human Sensory Neuropathies by Jocelyn Plassais (564630)

“…Clinical signs appear in young puppies and consist of acral analgesia, with or without sudden intense licking, biting and severe self-mutilation of the feet, whereas proprioception, motor abilities and spinal reflexes remain intact. Through a Genome Wide Association Study (GWAS) with 24 affected and 30 unaffected sporting dogs using the Canine HD 170K SNP array (Illumina), we identified a 1.8 Mb homozygous locus on canine chromosome 4 (adj. p-val = 2.5x10^-6). …”

Incubation of V79-CYP3A94/DD-POR cells with Shield-1 leads to a decrease of POR protein. by Ramona Dettwiler (664360)

Data from: Colony losses of stingless bees increase in agricultural areas, but decrease in forested areas by Malena Sibaja Leyton (18400983)

IUGR pups have decreased cell proliferation at age P14 compared to sham controls. by Camille M. Fung (844334)

“…IUGR decreased the number of Ki-67⁺ cells at P14 only compared to shams (n = 5 for each treatment group, p = 0.04, representative micrographs from P14 mice are shown as the lower panel of A). …”

HAART does not affect CTLA-4 expression, but significantly decreases CD39 expression in Tregs. by Pietro Presicce (144163)

HAART decreased enhanced expression of cell cycling markers in Tregs from HIV-infected subjects. by Pietro Presicce (144163)

The experimental set-up we used. by Hillary Jean-Joseph (9676166)

GUCY2C ligand supplementation decreases intestinal permeability and susceptibility to DSS-induced colitis. by Jieru Egeria Lin (181534)

Gene ontology biological processes overrepresented among genes exhibiting decreased expression in human psoriasis. by William R. Swindell (175427)

“…<p>A total of 3540 transcripts were identified as significantly decreased in psoriatic plaques obtained from human patients relative to normal skin obtained from control subjects (FDR-adjusted P<0.05 and log₂-transformed fold-change less than -0.50). …”

Packaging of multiple cleavage enzymes that target different HBV regions enhances potency and decreases resistance. by Joshua T. Schiffer (430730)

“…<p>Simulation of HBV eradication employing gene therapy following a single dose. Each data point represents number of remaining infected cells (y-axis) after a simulation with one of 36 unique parameter sets. x-axis is functional multiplicity of infection (fMOI). …”