Molecular Dynamics Characterization of Five Pathogenic Factor X Mutants Associated with Decreased Catalytic Activity by Safwat Abdel-Azeim (153436)

Subjects:

Molecular Dynamics Characterization of Five Pathogenic Factor X Mutants Associated with Decreased Catalytic Activity by Safwat Abdel-Azeim (153436)

Subjects:

Tun increases mitochondrial fission, inflammatory cell infiltration, and decreased ER-mitochondria interaction in neonatal rat lungs. by Kirkwood A. Pritchard Jr. (13449794)

“…The decreased expressions of GRP75 (0.5±0.2-fold, p = 0.006767, n = 5) and acyl-CoA synthetase long-chain family member 4 (ASCL4; 0.3±0.1-fold, p<0.001, n = 5) indicate a decreased interaction between ER and mitochondria by Tun. …”

Discovery of the Triazolo[1,5‑<i>a</i>]Pyrimidine-Based Derivative WS-898 as a Highly Efficacious and Orally Bioavailable ABCB1 Inhibitor Capable of Overcoming Multidrug Resistance... by Shuai Wang (109515)

“…Here, we reported our medicinal chemistry efforts that led to the discovery of the triazolo­[1,5-<i>a</i>]­pyrimidine derivative <b>WS-898</b> as a highly effective ABCB1 inhibitor capable of reversing paclitaxel (PTX) resistance in drug-resistant SW620/Ad300, KB-C2, and HEK293/ABCB1 cells (IC₅₀ = 5.0, 3.67, and 3.68 nM, respectively), more potent than verapamil and zosuquidar. …”

Discovery of the Triazolo[1,5‑<i>a</i>]Pyrimidine-Based Derivative WS-898 as a Highly Efficacious and Orally Bioavailable ABCB1 Inhibitor Capable of Overcoming Multidrug Resistance... by Shuai Wang (109515)

“…Here, we reported our medicinal chemistry efforts that led to the discovery of the triazolo­[1,5-<i>a</i>]­pyrimidine derivative <b>WS-898</b> as a highly effective ABCB1 inhibitor capable of reversing paclitaxel (PTX) resistance in drug-resistant SW620/Ad300, KB-C2, and HEK293/ABCB1 cells (IC₅₀ = 5.0, 3.67, and 3.68 nM, respectively), more potent than verapamil and zosuquidar. …”

Androgen and staurosporine synergize to decrease the relative ATP concentration in HPr-1AR cells. by Congcong Chen (796149)

“…In comparison to vehicle control, STS and to a lesser extent DHT significantly decrease the relative ATP concentration of HPr-1AR cells at 24 hours. …”

LiCl, TSA, and MTR decrease polyQ mediated ASH neuronal death. by Cindy Voisine (30589)

Anti-EBOV GP IgGs Lacking α1-3-Galactose and Neu5Gc Prolong Survival and Decrease Blood Viral Load in EBOV-Infected Guinea Pigs by Olivier Reynard (354756)

“…In this paper, we explored whether low immunogenicity IgGs had a protective effect on a guinea pig model of Ebola virus (EBOV) infection. …”

MMP-2 production is decreased following ALK5 inhibition. by Rebecca A. Scott (488956)

<i>Oenocarpus bacaba</i> palm tree (A) and fruit (B). by Eudes Alves Simões-Neto (19697968)

“…Managing ACD remains challenging even after more than 100 years of its discovery. Its spread to non-endemic areas has made it a global health issue. …”

Endoplasmic reticulum calcium decrease via RyR in response to HIV-1 Tat. by John P. Norman (269281)

AS021 activity and Satb2 expression decrease within deep layers at postnatal stages. by Kensuke Tashiro (193459)

“…For each bin, 10–200 βgal⁺ cells were counted and 200–500 Satb2⁺ cells were counted in at least two animals for each stage. Graphs show mean ± SEM. Scale bars: 200 µm (A), 100 µm (B).</p>…”

Fig 5 - by Thomas Jacquet (9960275)

Alternative bounded and monotonically decreasing functions do not accurately fit the bias in the naïve SI. by Liron Sheintuch (12078310)

“…Data in A-C show the mean across 100 cells from one example simulation. …”

Decreased mRNA levels of inflammatory cytokines from <i>cpdm</i> BMDC. by Zhe Wang (41178)

DCD is strikingly decreased in HS lesions. by Margaret Coates (6058580)

“…Co-staining was performed with K77 (green), which is a marker of eccrine sweat glands. Scale bar is 100μm. (C) Immunofluorescence for DCD (red) and K77 (green) at 4X showing decreased number of eccrine sweat glands in HS lesional skin. …”

hESCs-Exo decreased cancer cell proliferation and increased cancer cell death. by Shufeng Zhou (398572)

Taurocholate significantly decreases toxin B-mediated Caco-2 cell membrane integrity. by Charles Darkoh (482779)

MALT1 inhibition in mDCs decreases cytokine production in zymosan-treated cells. by Celine Dumont (9327751)

Distribution of scaling factor γ after 100 rounds of sparsity training with different sparsity rates λ. by Zhongjian Xie (4633099)