Post-stimulus undershoot and vasomotion persist with different GC activation levels. by William Davis Haselden (9175156)

“…A) The perivascular NO concentration was evaluated for a baseline NO concentration eliciting 25% activation of the smooth muscle (green) or 50% GC activity with an EC₅₀ of 3.9 nM and Hill coefficient of 2.1 [<a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1008069#pcbi.1008069.ref149" target="_blank">149</a>] (gray). …”

Nanog interferes with the binding of β-catenin to Tcf7 in vitro and in vivo. by Mudan He (7017239)

Table_1_Prognostic value of temporal patterns of global longitudinal strain in patients with chronic heart failure.DOCX by Sabrina Abou Kamar (14393709)

“…We compared hazard ratios (HRs) for the endpoint from Cox models (used to analyze the first available GLS measurements) with HRs from joint models (which links repeated measurements to the time-to-event data).</p>Results<p>Mean age was 58 ± 11 years, 76% were men, 81% were in New York Heart Association functional class I/II, and all had LVEF < 50% (mean ± SD: 27 ± 9%). …”

Training data preparation. by Refat Khan Pathan (16871953)

“…Using this time series analysis method, the prospective mutation rate of the 50^th patient has been predicted. Note that this is a new report on the monkeypox gene mutation. …”

Qualitative histological assessment of fixed and unfixed tissue biomaterials following cyclic deformation. by Ailsa J. Dalgliesh (6836807)

“…<p>Nuclei density was maintained across all groups regardless of cycle number (hematoxylin and eosin (H&E)) (A). Elastin content decreased with increasing number of cycles for glutaraldehyde-fixed bovine pericardium, whereas both porcine and bovine pericardium maintained elastin content (Verhoeff-Van Gieson (VVG)) (A). …”

Tacrolimus and MPA can inhibit signaling pathway activation in whole-blood samples. by Nynke M. Kannegieter (3697594)

“…<p>(A) Phospho-p38MAPK (upper left panel), p-ERK (upper right panel) and p-Akt (lower panel) phosphorylation in monocytes was measured as MFI level. …”

QC, including cluster size thresholding and declumping, improves precision, sometimes at the expense of recall, for images with lower SNR values. by Jenny M. Vo-Phamhi (11250803)

“…<b>(C)</b> Thresholding clusters by the number of annotations in the cluster and by the fraction of unique workers who contribute multiple times to the cluster improved recall by 17%, while decreasing precision by 11% on average, in an experiment with nine images with 50, 100, and 150 spots; mean SNR = 5, 10, and 15; and average nearest neighbor distance (NND) ≈ 11.5, 15, and 20.5.…”

Substitution mutation rate. by Refat Khan Pathan (16871953)

“…Using this time series analysis method, the prospective mutation rate of the 50^th patient has been predicted. Note that this is a new report on the monkeypox gene mutation. …”

Characteristics of the fatiguing protocols. by Maria Papaiordanidou (505330)

“…Torque significantly decreased for both protocols from the second 50-train set. …”

Schematic of acoustic startle reflex (ASR) under conditions of pre-pulse (pASR) or gap (gASR) inhibition. by Avril Genene Holt (358835)

“…If a 50 ms tone preceding a 50 ms silent period is introduced and detected just prior to the startle stimulus, usually a decreased startle reflex is observed. …”

Histopathological lesions in SFTSV-Infected humanized mice. by Shijie Xu (3324546)

“…Areas of interest (AOI) are enlarged, and quantitative graphs are presented at the right. (A) Decreased cellularity and obvious lymphocyte depletion in the red pulp (RP) of the spleen at sacrificed day. …”

8oxoG inhibits TRF1 binding to telomeric DNA by Patricia L. Opresko (7493)

“…Substrates (2.5 nM) were incubated alone (−) or together with decreasing concentrations of purified TRF1 (200, 100, 50 or 25 nM) (lanes 2–5, 7–10, and 12–15, 17–20, 22–25 and 27–30) for 20 min at 4°C in TEL buffer. …”

Differentially expressed genes in <i>Tnfr</i>-deficient glomeruli compared to wildtype after TNF stimulation. by Anela Taubitz (433585)

“…<p>Expression profiling by microarrays was performed on isolated glomeruli from wildtype, <i>Tnfr1,2</i>−/−, <i>Tnfr1</i>−/− and <i>Tnfr2</i>−/− mice after stimulation with 50 ng/ml TNF for 12 hours ex vivo. <b>A:</b> Significance analysis using SAM detected differential regulation of 290 unique genes in <i>Tnfr1,2</i>−/− glomeruli with at least 1.5-fold difference compared to wildtype (black data points). 219 genes were down-regulated (upper left), and 71 genes were up-regulated (lower right). …”

<i>pelo</i> regulates the syntheses of some specific DCV proteins. by Xiurong Wu (247941)

“…Results were normalized to mock control and represent the mean ± SD of triplicates. (<b>D</b>) The quantities of metabolically labeled proteins (15–250 KD) were determined as decreased in <b>B</b>. …”

Altered TRPV1 staining in paw skin tissue obtained from STZ-induced diabetic mice by Reddy M Pabbidi (44094)

“…Summary graph showing increased (n = 8 sections from 4 mice, p < 0.05) and decreased (n = 9 sections, p < 0.05) mean gray values of TRPV1 staining in diabetic hyperalgesic and hypoalgesic fibers of the paw dermis layer as compared with control non-diabetic mice (n = 8 sections from 4 mice). …”

Continual Cell Deformation Induced via Attachment to Oriented Fibers Enhances Fibroblast Cell Migration by Sisi Qin (564059)

“…In vivo, migration occurs on fibrillar substrates, and previous observations have shown that a significant time lag exists before the onset of granulation tissue. …”

MMP3 induced mitochondrial ROS regulate the Nox1 expression in 6-OHDA treated N27 cells. by Dong-Hee Choi (617376)

“…NNGH, apocynin, and GKT significantly inhibited decreasing of 6-OHDA-mediated ΔΨm. Apo: apocynin, a Nox inhibitor; GKT: GKT137831, a Nox1 selective inhibitor; AA, antimycin A (100 µM); FCCP, an oxidative phosphorylation uncoupler (100 nM), Results are presented as the mean ± SEM, n = 8. ** p<0.01, ***p<0.001 vs. nontreated control; # p<0.05, ## p<0.01, ### p<0.001 vs. 6-OHDA control. …”

Identification of epitope of the G8 mAb. by Jacquelyn Gerhart (552473)

“…For each mutant clone, the mean binding value was plotted as a function of expression represented by control antibody reactivity. …”

DataSheet_1_Associations of chest X-ray trajectories, smoking, and the risk of lung cancer in two population-based cohort studies.docx by Ya Liu (205636)

“…If participants gained positive CXR, LC incidence risk significantly climbed to 22.04(15.37–31.60) and 71.97(48.82–106.09) for ever and current smokers, while LC mortality risk climbed to 11.90(8.58–16.50) and 38.92(27.04–56.02). CXR_LP was associated with decreased LC risk. …”

Depletion of aquaglyceroporins reduces parasite load in <i>P</i>. <i>berghei</i> infected HuH7 cells. by Dora Posfai (4819011)

“…<p>(A) Relative mRNA expression of cells that were targeted by pooled AQP3 or SR-BI siRNAs at 50 nM. …”