Anti-TNF Thioester Glucocorticoid Antibody–Drug Conjugate Fully Inhibits Inflammation with Minimal Effect on Systemic Corticosterone Levels in a Mouse Arthritis Model by Christopher C. Marvin (1338228)

“…Mouse PK indicated that <b>6</b> is cleared 10-fold more rapidly than a first-generation GRM payload, resulting in 10-fold lower exposure and 3-fold decrease in Cmax. …”

Anti-TNF Thioester Glucocorticoid Antibody–Drug Conjugate Fully Inhibits Inflammation with Minimal Effect on Systemic Corticosterone Levels in a Mouse Arthritis Model by Christopher C. Marvin (1338228)

“…Mouse PK indicated that <b>6</b> is cleared 10-fold more rapidly than a first-generation GRM payload, resulting in 10-fold lower exposure and 3-fold decrease in Cmax. …”

S5 Fig - by Cynthia Alsayyah (18452506)

“…**<i>P</i> < 0.05 (one-way analysis of variance (ANOVA)). More than 100 cells per sample were analyzed. Note the significant decrease in tubular mitochondria upon inactivation of <i>CTP1</i> in all conditions, including TEF-<i>OLE1</i>. …”

One-step growth cycle of CVB3 wild type and M1-M6 mutant viruses in HeLa cells. by Jawhar Gharbi (11492361)

Effects of NDGA on the expression of JA synthesis-related genes. by Hiroaki Tamaki (758505)

The suppressive effect of an A2AR agonist on the proliferation of CFSE-labeled αβ T cells is decreased in the presence of A2AR⁺ γδ T cells. by Dongchun Liang (636452)

HPV16 PsV infection decreases following SLPI treatment or anti-annexin A2 antibody inhibition of A2t. by Andrew W. Woodham (140650)

Effect of thalidomide on CUL5 and NEDD8 localization in control and si-transfected HUVEC at 24 hours after treatment. by Bryan Kunkler (5204327)

Raw data 1–5. by Fateme Khorramroo (18086501)

AO/EtBr Staining of Cancer cell lines: <i>To check whether vitamin D3 promoted cell death in cancer cells, a dual staining protocol was implemented as detailed in the methods secti... by Vidya G. Bettada (22208808)

<i>Slc13a5</i>^<i>-/-</i> mice had decreased enamel volume as measured with μCT. by Armando R. Irizarry (422739)

Decreased Paneth cell number and the presence of granulomas differentiate HbTg from Tg animals at 10 days post Tg infection. by Edina K. Szabo (3160332)

Reduced follicles, decreased ovulation and decreased fertilization of female Meox-2-cre/Separase S1121A mutant mice. by Juan Xu (225010)

Graphs showing the mean maximum temperature increase at the position with the highest mean temperature increase (A) and the mean temperature increase across all probes (B) for each... by Marsel Ganeyev (21453399)

R₇-fused peptides inhibit FMDV production in BHK-21 cells. by Mónica González-Magaldi (638526)

Table S1 - Human <i>NR5A1</i>/SF-1 Mutations Show Decreased Activity on BDNF (Brain-Derived Neurotrophic Factor), an Important Regulator of Energy Balance: Testing Impact of Novel SF-1 Mutations Beyond Steroidogenesis by Jana Malikova (615672)

Subjects:

The log concentration-time profiles of unbound drug in brain ECF (<i>C</i>_ECF) with 1000x increased permeability <i>P</i> (left to right, 0.1⋅10^-7 m s<sup>-1<... by Esmée Vendel (9411408)

The PK on log-scale of unbound drug in brain ECF (<i>C</i>_ECF) with 1000x increased permeability <i>P</i> (left to right, 0.1⋅10^-7 m s^-1 to 100⋅10<... by Esmée Vendel (9411408)

Decrease of viral load and ALT at different time points under treatment according to NS5A-inhibitors and interferon administration. by Valeria Cento (103603)

Flowchart displaying the steps of the present study. by Jingtian Yang (11966345)