ELISA analysis revealed a significant decrease in SP (A & B) and CGRP (C & D) protein levels in the corneas and tear fluid of mice treated with 0.5% bupivacaine (BUP) every alternate day for 15 days (administered via subconjunctival injection (SCI) alone or in combination with topical (TOP) application) compared to PBS-treated controls. by Ananya Datta (19932144)

Fold changes in selected lung tissue mRNAs specific for mucin (Muc4, Muc5ac, and Muc5b) and Th2 cytokine (IL-4, IL-5, and Il-13) genes, after mice were fed (n-3) or (n-6) PUFA enri... by Jean A. Hall (289030)

Fluoxetine decreases TOPFlash firefly luciferase reporter activity. by Kentaro Miyamoto (123271)

RNA analysis reveals a ~6-fold reduced coverage of exon 26 in the murine <i>Tg</i> gene. by Wendy J. Bailey (14926392)

“…<p>(A) <i>Tg</i> transcriptional coverage in B6NCrl (CRL) and B6NTac (Taconic) thyroid samples determined by RNAseq. …”

Quantitative PCR of RNA from lung cells demonstrates a decrease in negative regulators of Th1 immunity in Mtb challenged vaccinated rats. by Amit Singhal (193686)

Decreased alveolar levels of TNF-α and IL-6R levels in ADAM17-null mice. by Patrick G. Arndt (351620)

Large state-wide variation (8.5-fold) in number of clozapine prescriptions per thousand Medicare Part D enrollees in 2019 ^a indicates ≥1.50 SD (16.8) from the mean (31.0... by Luke R. Cavanah (19022435)

Exploration of up- and down-regulated genes at each UV irradiation time-point. by Seon-Pil Jin (17364626)

PGRN deletion decreased the susceptibility to invasive <i>C</i>.<i>albicans</i> infection in mice. by Jiayu Liu (3951515)

Autophagosomal sequestration of Aβ42 in brain of autophagy-hyperactive mice. by Altea Rocchi (3278457)

L1-induced transcription decreases SV40 transcription and causes intron retention in ABCA minigene. by Kristel Kaer (50417)

Decreased CD39 protein expression by islet resident macrophages heralds T1D in NOD mice. by Thomas B. Thornley (2550766)

Rac1 activity rapidly decreases upon cell-cell adhesion in 3-D cell aggregates. by Khameeka N. Kitt (227731)

“…High levels of active Rac1 at 0 minutes rapidly decreased (∼66%) within 5 minutes of cell-cell adhesion, and declined to a baseline level by 30 minutes (A). …”

<i>Becn1</i>^F121A leads to autophagy hyperactivation in vivo. by Altea Rocchi (3278457)

Down-regulation of Bim in EBV-positive cells is not due to proteosomal degradation or decreased mRNA stability. by Kostas Paschos (262658)

Waning of BCG-induced protection against <i>Mtb</i> coincides with decreased T-cell functional capacity. by Subhadra Nandakumar (212501)

A647D mutation decreases I_Na of WT and P1332L when co-expressed. by Jie Liu (15128)

Insulin decreases the interspike interval (ISI) and cluster pause duration of mitral cell action potential activity. by Debra Ann Fadool (332114)

Decreased miR-24 sensitizes cells to apoptotic stimuli, and increases pro-apoptotic protein expression. by Tan Nguyen (278146)

“…Infected cells were selected in puromycin and decreased expression of miR-24 validated by quantitative RT-PCR (<b><a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0055406#pone.0055406.s004" target="_blank">Fig S4</a></b>). …”

Intracellular levels of HSPG core proteins, HS and HPSE are decreased in ER stressed MIN6 cells. by Sarita Dhounchak (10924448)