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141
Survivin deletion in beta cells leads to decreased beta-cell mass.
Published 2012“…<p>(a) Male and female mutant mice exhibit decreased beta-cell mass at 2-month of age as compared to controls (n = 5 per genotype). …”
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Simultaneous ablation of Syt1 and Syt7 decreases the RRP size at inhibitory synapses: Rescue by WT but not mutant Syt1 or Syt7.
Published 2015“…Recordings were performed in the presence of 1 μM tetrodotoxin, 20 μM CNQX, and 50 μM AP5 to isolate inhibitory currents. <b>B.</b> Simultaneous ablation of Syt1 and Syt7 decreases the RRP size of inhibitory synapses in a manner that is rescued by WT Syt7 (Syt1<sup>WT</sup>) but not Syt7 with mutations in the top C2 domain sequences containing the Syt7 Ca<sup>2+</sup> binding sites (Syt7<sup>C2A</sup>*<sup>B</sup>*). …”
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In the absence of chloride, two-fold decrease in [Na<sup>+</sup>]<sub>e</sub> shifted GLT-1a E<sub>rev</sub> by −28 mV at both low and high glutamate concentrations.
Published 2015“…Arrows show amplitudes and directions of E<sub>rev</sub> shifts associated with decrease in [Na<sup>+</sup>]<sub>e</sub>. <b>(D)</b> Average E<sub>rev</sub> shifts at [Glu<sup>-</sup>]<sub>e</sub> geometric means of 37.5 and 600 μM are approximately equal when [Na<sup>+</sup>]<sub>e</sub> was decreased from 102 to 51 mM. …”
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157
Wnt5a expressing tumors demonstrate a decrease in markers of the basal tumor subtype.
Published 2014“…MMTV-Wnt1;MMTV-Wnt5a tumors demonstrated a significant decrease in K6-expressing cells as measured by T-test (* = p<0.05).…”
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Cycloheximide (CHX) treatment decreases production of rRNA transcripts by POLR1 and POLR3.
Published 2019“…<p>(A) DAOY cells were treated with CHX (100 μg/ml) for either 6 or 14 hours; for metabolic RNA labelling, 5-EU was added 2 hours before the sample collection. …”