Anti-tumor effects of DEspR-inhibition in Panc1-CSC xenograft tumors in nude rats. by Victoria L. Herrera (383897)

“…(E) Representative images of tumor expanding zones with identical exposure settings depict robust differences in key histopathological parameters pertinent to efficacy determinations in Panels A, C and D between non-treated control (Non-treated) and anti-DEspR mAb treated (Treated) nude rat subcutaneous Panc1-CSC xenograft tumors: 1) cellularity (H&E: Cell Density, 2) mitotic index (Masson Trichrome MT: mitotic profile), 3) extent of tumor invasiveness to adjacent normal tissue (MT: invasiveness), and 4) human-specific CD31+ and human-specific 7c5b2 DEspR+ fluorescent immunostaining of microvessels and adjacent tumor cells (IF: microvascularity). …”

Roflumilast-Mediated Phosphodiesterase 4D Inhibition Reverses Diabetes-Associated Cardiac Dysfunction and Remodeling: Effects Beyond Glucose Lowering by Rui Xu (158313)

“…Mice on HFD developed diabetes and cardiac dysfunction with increased cardiac PDE4D5 expression. PDE4 inhibitor roflumilast can reverse hyperglycemia and cardiac dysfunction, accompanied by the decrease of PDE4D expression and increase of muscle-specific microRNA miR-1 level in hearts. …”

Table_1_Feeding Faba Beans (Vicia faba L.) Reduces Myocyte Metabolic Activity in Grass Carp (Ctenopharyngodon idellus).DOCX by Jing-jing Tian (778123)

“…<p>In this study, we aimed to explore the effects of faba bean (Vicia faba L.) on the energy metabolism of grass carp (Ctenopharyngodon idellus). A total of 180 fish (∼2900 g) were randomly assigned to six tanks (2.5 × 2.5 × 1.2 m; 30 individuals per tank) and fed either faba bean (Vicia faba L.) or a commercial diet for 120 days (3% body weight, twice per day). …”

Foxg1-Cre Mediated Lrp2 Inactivation in the Developing Mouse Neural Retina, Ciliary and Retinal Pigment Epithelia Models Congenital High Myopia by Olivier Cases (760028)

“…Immunomorphological and ultrastructural analyses showed that increased eye lengthening was first observed by post-natal day 5 (P5) and that it was accompanied by a rapid decrease of the bipolar, photoreceptor and retinal ganglion cells, and eventually the optic nerve axons. …”

Table_1_Feeding Faba Beans (Vicia faba L.) Reduces Myocyte Metabolic Activity in Grass Carp (Ctenopharyngodon idellus).DOCX by Jing-jing Tian (778123)

“…<p>In this study, we aimed to explore the effects of faba bean (Vicia faba L.) on the energy metabolism of grass carp (Ctenopharyngodon idellus). A total of 180 fish (∼2900 g) were randomly assigned to six tanks (2.5 × 2.5 × 1.2 m; 30 individuals per tank) and fed either faba bean (Vicia faba L.) or a commercial diet for 120 days (3% body weight, twice per day). …”

Data_Sheet_1_Assessment of Climate Change Impacts on Chilling and Forcing for the Main Fresh Fruit Regions in Portugal.PDF by Helder Fraga (633694)

“…Future projections show a clear decrease in chilling for all regions and fruit types in Portugal. …”

Data_Sheet_3_Omeprazole Increases the Efficacy of Acyclovir Against Herpes Simplex Virus Type 1 and 2.PDF by Martin Michaelis (23843)

“…Omeprazole 80 μg/mL caused a 10.8-fold (Vero cells) and 47.7-fold (HaCaT cells) decrease of the acyclovir concentrations that reduced HSV-1-induced CPE formation by 50% (IC₅₀). …”

Housing and road transport modify the brain neurotransmitter systems of pigs: Do pigs raised in different conditions cope differently with unknown environments? by Laura Arroyo (3422744)

“…After one month, one set of animals from each housing condition were driven in a truck to the slaughterhouse in low-stress conditions (5 min drive, no mixing groups, soft management, LS group, n = 12) or high-stress conditions (2 hours drive, mixing groups, harsh management, HS group, n = 12). …”

Data_Sheet_1_Preparation of nano-selenium from chestnut polysaccharide and characterization of its antioxidant activity.docx by Shanshan Wang (283009)

“…The DPPH free radical scavenging rate of purified polysaccharide fraction CP-1a was slightly enhanced, and the other rates showed a small decrease. …”

Quantitative Analysis of the Extracellular Response Kinase 1 and 2 (ERK1/2), Calcium-Calmodulin Kinase II (CAMKII), Fragile X Protein (FMRP), and the Nicotinic Acetylcholine Recept... by Robert K. Naviaux (256148)

“…<p>(A) ERK1 (MAPK3) and ERK2 (MAPK1) phosphorylation was decreased by over 90% by gestational poly(IC) exposure and normalized by suramin treatment (Sal-Sal = 100+/−5%; Sal-Sur = 6.2+/−0.8%; PIC-Sal = 9.9+/−2.6%; PIC-Sur = 84+/−2.3%; one-way ANOVA F(3,12) = 241; p<0.0001; n = 4–5 males per group; age = 16 weeks). …”

CAR pre-treatment reduced infarct volume and improved neurological deficits after MCAO. by Hailong Yu (329340)

“…(D)Neurological scores were evaluated according to a 5-points scale system. CAR treatment significantly decreased neurological deficits. …”

Image_1_Gauging response time distributions to examine the effect of facial expression inversion.tif by David L. Bimler (14674541)

“…Image pairs (N = 225) were presented for 500 ms, upright or inverted, in a block design, each 100 times.</p>Results<p>For both upright and inverted FEs, RTs were a non-monotonic function: median values were longest for stimulus pairs of intermediate similarity, decreasing for both more-dissimilar and more-similar pairs. …”

Image_2_Gauging response time distributions to examine the effect of facial expression inversion.tif by David L. Bimler (14674541)

“…Image pairs (N = 225) were presented for 500 ms, upright or inverted, in a block design, each 100 times.</p>Results<p>For both upright and inverted FEs, RTs were a non-monotonic function: median values were longest for stimulus pairs of intermediate similarity, decreasing for both more-dissimilar and more-similar pairs. …”

γδ T cells have similar TCR threshold but enhanced ERK1/2 phosphorylation comparing to αβ T cells. by Hsin-Yuan Cheng (414160)

“…Results were averaged from 5 mice, and shown in mean ± SEM. Lower: Log scaling of αCD3 concentration against % of maximum response was used to calculate EC₅₀. …”

Neurobehavioral performance at baseline and during chronic partial sleep deprivation for the <i>PER3</i> groups. by Namni Goel (336535)

“…<p>Mean (±SEM) (A) PVT lapses (>500 ms reaction times) per trial, (B) total number correct per trial on the Digit Symbol Substitution Task (DSST) and (C) Digit Span (DS) task, and scores per trial on the (D) Karolinska Sleepiness (KSS) and (E) “Fresh-Tired” Visual Analog Scale (VAS) at baseline (B) and each partial sleep deprivation/restriction night (SR1-SR5) for <i>PER3^4/4 (open circles)</i>, <i>PER3^4/5 (gray triangles)</i> and <i>PER3^5/5 (closed circles)</i> subjects. …”

Antioxidant activity of BT and plasma. by Wei-Yi Wu (1785187)

“…H₂O₂ scavenging activity was indicated by CL counts in several kinds of water. CL counts were decreased by 0.5 BT, 1 BT, 2 BT and 5 BT (n = 3). RO, reverse osmosis. …”

hGAG suppresses p38 and ERK signaling to inhibit TF expression in B16F10 tumor cells. by Yang Zhao (39052)

“…PMA-induced expression of TF in B16F10 tumor cells was significantly decreased by hGAG at >0.5 µM. All data are represented as mean ± S.E. from 3–5 independent experiments. …”

Suppressing Polysulfide Dissolution via Cohesive Forces by Interwoven Carbon Nanofibers for High-Areal-Capacity Lithium–Sulfur Batteries by Jong Hyuk Yun (4687930)

“…Thus, we demonstrate an electrospun carbon nanofiber (CNF) matrix for a sulfur cathode. This simple design enables a high mass loading of 10.5 mg cm^–2 with a high specific capacity and stable cycling. …”

Low-dose radiation differentially regulates protein acetylation and histone deacetylase expression in human coronary artery endothelial cells by Zarko Barjaktarovic (193549)

“…Data were validated using immunoblotting, deacetylase activity assay, and RhoA activity assay.</p> <p><b>Results:</b> Nearly a hundred proteins were found to have an altered acetylation status 24 h after irradiation, primarily due to an overall decrease in acetylation. …”

Effect of enzymatic complex in the diet of pirarucu, Arapaima gigas juveniles by Julliana de Castro LIMA (12678327)

“…The experimental design was randomized with four treatments [diets containing 0.25, 0.50, 0.75, and 1 g kg-1 on-top inclusion of an enzyme complex (Allzyme® SSF®, USA), and a control, with three replications at a density of 5 fish per unit, and a 30-day duration. …”