Presentation_1_Regulatory Role of Hexokinase 2 in Modulating Head and Neck Tumorigenesis.PPTX by Wan-Chun Li (450324)

“…Loss of HK2 in HNSCC cells resulted in reduced cell (in vitro) and tumor (in vivo) growth, as well as decreased epithelial-mesenchymal transition–mediated cell movement; in contrast, HK2-deficient HNSCC cells exhibited greater sensitivity to chemotherapeutic drugs cisplatin and 5-fluorouracil but are more resistant to photodynamic therapy, indicating that HK2 expression could selectively define treatment sensitivity in HNSCC cells. …”

Image_4_Low-Dose Antibiotic Prophylaxis Induces Rapid Modifications of the Gut Microbiota in Infants With Vesicoureteral Reflux.TIF by William Morello (10984251)

“…</p><p>Conclusions: In infants with VUR, even a short exposure to CAP definitely alters the GM composition, with increased relative abundance of opportunistic pathogens and decreased proportions of health-promoting taxa. …”

Data Sheet 3_Beyond salt tolerance: SOS1-13’s pivotal role in regulating the immune response to Fusarium oxysporum in Solanum phureja.docx by Liqin Liang (652560)

“…Furthermore, the expression of SA and JA response-related genes (NbPR5 and NbPR12) was up-regulated in NbSOS1-13-silenced plants.…”

Data_Sheet_1_Threshold Reaction of Soil Arthropods to Simulative Nitrogen Deposition in Urban Green Spaces.pdf by Lingzi Mo (11645293)

“…Although higher doses of N addition showed adverse effects on soil fauna communities, low N inputs increased the soil fauna diversity and richness, especially at 5–10 cm depth. A threshold effect appears to exist low nitrogen addition (<25 kg N ha^–1) did not affect negatively pedofauna structure and composition, while in the range from these values up to 50 kg N ha^–1, the composition of the soil fauna underwent major changes confirmed by the decline of biodiversity indices. …”

Image_1_Fenofibrate Ameliorated Systemic and Retinal Inflammation and Modulated Gut Microbiota in High-Fat Diet-Induced Mice.pdf by Xue Wang (102830)

“…<p>Fenofibrate, as a lipid-lowering drug, has been reported to have a protective effect on the retina independent with plasma lipid levels. …”

Table3_Olanzapine Promotes the Occurrence of Metabolic Disorders in Conditional TCF7L2-Knockout Mice.xlsx by Ye Yang (297214)

“…RT-qPCR revealed that the CKO mice presented a significantly less transcription of Sp5, an important element of the Wnt signaling pathway.…”

Data_Sheet_1_Mendelian randomization shows causal effects of birth weight and childhood body mass index on the risk of frailty.DOCX by Junhao Cui (18601693)

“…</p>Results<p>Genetically predicted one standard deviation (SD) increase in own birth weight, but not offspring birth weight (maternal-specific), was linked to a decreased frailty index (β per SD increase = −0.068, 95%CI = −0.106 to −0.030, p = 3.92E-04). …”

Presentation_1_Regulatory Role of Hexokinase 2 in Modulating Head and Neck Tumorigenesis.PPTX by Wan-Chun Li (450324)

“…Loss of HK2 in HNSCC cells resulted in reduced cell (in vitro) and tumor (in vivo) growth, as well as decreased epithelial-mesenchymal transition–mediated cell movement; in contrast, HK2-deficient HNSCC cells exhibited greater sensitivity to chemotherapeutic drugs cisplatin and 5-fluorouracil but are more resistant to photodynamic therapy, indicating that HK2 expression could selectively define treatment sensitivity in HNSCC cells. …”

Table_2_Transcriptional changes in the gilthead seabream (Sparus aurata) skin in response to ultraviolet B radiation exposure.xlsx by Ricardo N. Alves (8839895)

“…S. aurata juveniles were exposed for 43 days to two experimental groups: 1) UVB (daily dose, 6 kJ m^-2; representing levels between 5 and 7 m depth); 2) Unirradiated treatment, used as a control. …”

DataSheet1_Transcriptomic and Lipidomic Profiles in Nasal Polyps of Glucocorticoid Responders and Non-Responders: Before and After Treatment.DOCX by Zhenzhen Zhu (817819)

“…Higher expression of type 2 inflammatory molecules (CCL13, IGHE, CCL18, CCL23, CCR3, and CLC) with lower levels of LACRT, PPDPFL, DES, C6, MUC5B, and SCGB3A1 were related to a stronger clinical response to GC. …”

Specific cytolysis of ROR1⁺ tumor cells by CAR⁺ T cells. by Drew C. Deniger (747626)

“…Lysis data can be found in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0128151#pone.0128151.s001" target="_blank">S1 Dataset</a>, Fig 5 tab.…”

Table1_Tissue explants as tools for studying the epigenetic modulation of the GH-IGF-I axis in farmed fish.docx by Erick Perera (636690)

“…In particular, the expression of igfbp2a was increased and that of igfbp4, ghri and ghrii was decreased by DAC as well as by genistein, which is suggestive of impaired growth. …”

Image_2_Low-Dose Antibiotic Prophylaxis Induces Rapid Modifications of the Gut Microbiota in Infants With Vesicoureteral Reflux.TIF by William Morello (10984251)

“…</p><p>Conclusions: In infants with VUR, even a short exposure to CAP definitely alters the GM composition, with increased relative abundance of opportunistic pathogens and decreased proportions of health-promoting taxa. …”

Regorafenib: Antitumor Activity upon Mono and Combination Therapy in Preclinical Pediatric Malignancy Models by Estelle Daudigeos-Dubus (829658)

“…<i>In vitro</i> effects on cell proliferation were screened against 33 solid tumor cell lines of the Innovative Therapies for Children with Cancer (ITCC) panel covering five pediatric solid malignancies. Regorafenib inhibited cell proliferation with a mean half maximal growth inhibition of 12.5 μmol/L (range 0.7 μmol/L to 28 μmol/L). …”

Tissue and Stage-Specific Distribution of <em>Wolbachia</em> in <em>Brugia malayi</em> by Kerstin Fischer (131647)

“…In young adult worms (5 weeks p.i.), a massive expansion of <em>Wolbachia</em> was observed in the lateral chords adjacent to ovaries or testis, but no endobacteria were detected in the growth zone of the ovaries, uterus, the growth zone of the testis or the <em>vas deferens</em>. …”

Table_1_Acupuncture modulates the AMPK/PGC-1 signaling pathway to facilitate mitochondrial biogenesis and neural recovery in ischemic stroke rats.docx by Kaixin Guo (10656668)

“…Meanwhile, acupuncture treatment up-regulated the expression of the corresponding protein. (5) Subsequently, acupuncture enhanced AMPK phosphorylation as well as the expression of PGC-1α, NRF2, TFAM and UCP2, implicated in mitochondrial synthesis and cellular apoptosis. (6) Finally, injections of AMPK antagonists and activators confirmed AMPK as a therapeutic target for the anti-nerve damage effects of acupuncture.…”

PrP^CGPIThy-1 shows altered sorting. by Berta Puig (344828)

“…ZO1 (red) is expressed at the tight junction and delimitates the apical (a)/basolateral (b) side. Note that PrP^CGPIThy-1 relocalizes to the apical side compared to WTPrP^C, which is predominantly basolaterally located (scale bar is 5 μm). …”

Table_1_Can PIRCHE-II Matching Outmatch Traditional HLA Matching?.pdf by Christian Unterrainer (3839149)

“…PIRCHE-II scores were calculated based on split antigen HLA-A, -B, -DRB1 typing and adjusted to the 0–6 range of HLA mismatches. …”

Thalamic generation of propofol phase amplitude coupling by Austin Soplata (12089999)

“…We included propofol dose effects by increasing maximal conductance and decay time constant of GABAa-mediated inhibition by either 2X or 3X normal, and by decreasing maximal H-current conductance (gH). We then considered for each a pair of 2-D parameter spaces, varying gH and applied current corresponding to peak and trough phases of the cortical slow wave. …”

Table7_Olanzapine Promotes the Occurrence of Metabolic Disorders in Conditional TCF7L2-Knockout Mice.xlsx by Ye Yang (297214)

“…RT-qPCR revealed that the CKO mice presented a significantly less transcription of Sp5, an important element of the Wnt signaling pathway.…”