Image_2_Adeno-associated virus vector intraperitoneal injection induces colonic mucosa and submucosa transduction and alters the diversity and composition of the faecal microbiota... by Li-Tian Ma (13263204)

“…</p>Results<p>Our results showed (1) efficient transduction of the mucosa and submucosa of the ascending, transverse, and descending colon following AAV9 IP injection; (2) a decreased alpha diversity and an altered overall microbial composition following AAV9 IP injection; (3) significant enrichments in a total of 5 phyla, 10 classes, 13 orders, 15 families, 29 genera, and 230 OTUs following AAV9 IP injection; and (4) AAV9 can significantly upregulate the relative abundance of anaerobic microbiota which is one of the seven high-level phenotypes that BugBase could predict.…”

Data_Sheet_1_Arbuscular Mycorrhizal Fungus Alters Root System Architecture in Camellia sinensis L. as Revealed by RNA-Seq Analysis.xlsx by Weili Chen (3140463)

“…With respect to phytohormones, DEGs of auxin (13), ethylene (14), and abscisic acid (5) were extensively affected by AMF inoculation, especially for auxin and ethylene. …”

Table_1_Adeno-associated virus vector intraperitoneal injection induces colonic mucosa and submucosa transduction and alters the diversity and composition of the faecal microbiota... by Li-Tian Ma (13263204)

“…</p>Results<p>Our results showed (1) efficient transduction of the mucosa and submucosa of the ascending, transverse, and descending colon following AAV9 IP injection; (2) a decreased alpha diversity and an altered overall microbial composition following AAV9 IP injection; (3) significant enrichments in a total of 5 phyla, 10 classes, 13 orders, 15 families, 29 genera, and 230 OTUs following AAV9 IP injection; and (4) AAV9 can significantly upregulate the relative abundance of anaerobic microbiota which is one of the seven high-level phenotypes that BugBase could predict.…”

DataSheet1_Shabyar Ameliorates High Glucose Induced Retinal Pigment Epithelium Injury Through Suppressing Aldose Reductase and AMPK/mTOR/ULK1 Autophagy Pathway.docx by Xiao Yan Liu (1589545)

“…Western blotting and DCFH-DA probe assay showed that SBA decreased pAMPK/AMPK and pULK1/ULK1 which associated with autophagy initiation, down-regulated Beclin-1, Atg3, Atg5, Atg7, LC3 II and Bax/Bcl2 ratio, and up-regulated pmTOR/mTOR, SQSTM1/p62 and mitochondrial membrane potential (MMP), reduces intracellular autophagosomes. …”

Interferon-inducible Mx1 protein is highly expressed in renal tissues from treatment-naïve lupus nephritis, but not in those under immunosuppressive treatment by Yuka Shimizu (2194279)

“…</p> <p><b>Patients and methods:</b> Mx1 protein concentrations in (PBMCs) from 18 SLE patients mostly in their stable disease status, 11 IgA nephropathy (IgAN) patients, 5 ANCA-associated vasculitis (AAV) patients and 16 healthy controls were measured using enzyme-linked immunosorbent assay (ELISA). …”

Image 1_Ferulic acid inhibits ox-LDL-induced ferroptosis and apoptosis in RAW 264.7 cells via the HIF-1 signaling pathway.tif by Xize Wu (17584914)

“…FA upregulated the expression of ALOX5, BCL2, ERN1, GPX4, NOS3, and SLC2A1 mRNA and downregulated the expression of BAX, CYCS, EGFR, FLT1, HIF1A, NFKB1, NOS2, PARP1, and STAT3 mRNA. …”

Data_Sheet_1_Assessment of 10-Year Left-Ventricular-Remodeling by CMR in Patients Following Aortic Valve Replacement.pdf by Nina Rank (10337903)

“…</p><p>Results: The median of LVMI, EDVI, and ESVI decreased in both groups. Patients with AR had higher initial values of EDVI and ESVI and showed a more prominent initial reduction. …”

Table1_Resveratrol Enhances the Anti-Cancer Effects of Cis-Platinum on Human Cervical Cancer Cell Lines by Activating the SIRT3 Relative Anti-Oxidative Pathway.DOCX by Bin Jiang (196018)

“…The combinations of chemotherapy with cis-platinum were the first-line treatment in late-stage cervical cancer but may cause severe adverse effects. Resveratrol (RES, 3,5,4′-trihydroxy-trans-stilbene) is a phytoalexin, and it showed anti-cancer effects but with low toxicity and side effects. …”

Treatment with TrkB agonists reduces food intake and weight in mice. by John C. Lin (43821)

“…<p>a, Daily IV injection of 0.6, 2 or 4 mg/kg of NT4 (n = 6 per group) resulted in dose dependent reduction in average daily food intake over 5 days in adult male DIO mice (One way ANOVA, P = 0.0098, F = 4.967 with Dunnett's posttest, P<0.01 for 4 mg/kg group compared to the vehicle group, while no statistically significant effects were observed at 0.6 or 2 mg/kg). b, Daily IV injection of 0.6, 2 or 4 mg/kg of NT4 (n = 6 per group) resulted in dose dependent reduction in body weight in adult male DIO mice (Two way ANOVA, P<0.0001 with Bonferroni's posttests, data are presented as % change relative to baseline body weight). c, Weekly IV injection of 2 mg/kg BDNF (n = 7) or NT4 (n = 7) led to significant weight loss compared to the vehicle treatment (n = 8) in adult male DIO mice at 10 days after the first dose (One way ANOVA, P = 0.002, F = 9.08 with Dunnett's posttest). d, Single IV injection of 3 mg/kg TrkB agonist monoclonal antibody (n = 7) significantly reduced body weight relative to control IgG treatment (n = 7) in adult male DIO mice 10 days after dosing (Student's t test, 2 tailed, P = 0.04). e–f, Daily treatment of Leptin receptor-deficient, 12 week old female <i>db/db</i> mice for 30 days with IV-delivered 20 mg/kg of NT4 (n = 7) decreased daily food intake by 50–80% (e), and body weight by 40% (f) relative to the vehicle treated mice (n = 8).…”

Table_4_Distribution, Diversity, and Abundance of Nitrite Oxidizing Bacteria in the Subterranean Estuary of the Daya Bay.docx by Wei Sun (93580)

“…However, our understanding of Nitrospira distribution and their response to dynamic environmental parameters is still limited in the subterranean estuary (STE), a special environment of the mixed zone between land and sea. …”

Data_Sheet_4_Arbuscular Mycorrhizal Fungus Alters Root System Architecture in Camellia sinensis L. as Revealed by RNA-Seq Analysis.xlsx by Weili Chen (3140463)

“…With respect to phytohormones, DEGs of auxin (13), ethylene (14), and abscisic acid (5) were extensively affected by AMF inoculation, especially for auxin and ethylene. …”

Exercise-Induced Splanchnic Hypoperfusion Results in Gut Dysfunction in Healthy Men by Kim van Wijck (212826)

“…Splanchnic perfusion rapidly decreased during exercise, reflected by increased gap_g-apCO₂ from −0.85±0.15 to 0.85±0.42 kPa (p<0.001). …”

Data_Sheet_1_Plant Community Response to Forest Fuel Management in Patagonian Pine Plantations.PDF by María Melisa Rago (8895686)

“…We assessed initial vegetation response to fuel reduction treatments in five exotic conifer plantations in the Patagonian forest-steppe ecotone. …”

Photoacoustic Tomography of Human Hepatic Malignancies Using Intraoperative Indocyanine Green Fluorescence Imaging by Akinori Miyata (656507)

“…Indocyanine green (0.5 mg/kg, intravenous) was preoperatively administered to 9 patients undergoing hepatectomy. …”

Table 1_Ferulic acid inhibits ox-LDL-induced ferroptosis and apoptosis in RAW 264.7 cells via the HIF-1 signaling pathway.xlsx by Xize Wu (17584914)

“…FA upregulated the expression of ALOX5, BCL2, ERN1, GPX4, NOS3, and SLC2A1 mRNA and downregulated the expression of BAX, CYCS, EGFR, FLT1, HIF1A, NFKB1, NOS2, PARP1, and STAT3 mRNA. …”

Image4_Hypoxia-induced PD-L1 expression and modulation of muscle stem cell allograft rejection.JPEG by Jacob Raiten (20021262)

“…MuSCs were treated with 5% hypoxia for 72 h and further treated with IFN-γ to enhance PD-L1 expression. …”

DataSheet3_The Protective Effect of Pilose Antler Peptide on CUMS-Induced Depression Through AMPK/Sirt1/NF-κB/NLRP3-Mediated Pyroptosis.xlsx by Yue Hu (201714)

“…</p><p>Conclusion: The present work indicated that PAP has a protective effect on CUMS-induced depression. …”

Presentation1_The Protective Effect of Pilose Antler Peptide on CUMS-Induced Depression Through AMPK/Sirt1/NF-κB/NLRP3-Mediated Pyroptosis.pdf by Yue Hu (201714)

“…</p><p>Conclusion: The present work indicated that PAP has a protective effect on CUMS-induced depression. …”

<em>In Vivo</em> Binding and Retention of CD4-Specific DARPin 57.2 in Macaques by Pavel Pugach (242933)

“…<div><h3>Background</h3><p>The recently described Designed Ankyrin Repeat Protein (DARPin) technology can produce highly selective ligands to a variety of biological targets at a low production cost.…”

DataSheet4_The Protective Effect of Pilose Antler Peptide on CUMS-Induced Depression Through AMPK/Sirt1/NF-κB/NLRP3-Mediated Pyroptosis.docx by Yue Hu (201714)

“…</p><p>Conclusion: The present work indicated that PAP has a protective effect on CUMS-induced depression. …”