TMEM98 is genetically downstream of MYRF. by Sarah J. Garnai (6658520)

“…<p>(A-B) Taqman qRT-PCR analysis of RPE expressed genes important for nanophthalmos (<i>Myrf</i>, <i>Best1</i>, <i>Mfrp</i>, <i>Tmem98</i>) in <i>Myrf</i>^<i>+/fl</i>, <i>RxCre;Myrf</i>^<i>+/fl</i> and <i>RxCre;Myrf</i>^<i>fl/fl</i> eyes at P3 (A) and P22 (B). …”

Supplementary Figures from AZD9496: An Oral Estrogen Receptor Inhibitor That Blocks the Growth of ER-Positive and <i>ESR1</i>-Mutant Breast Tumors in Preclinical Models by Hazel M. Weir (2123344)

“…<p>Supplementary Figure 1 contains a Western blot showing the amount of estrogen receptor remaining after treatment of MCF-7 cells with AZD9496, fulvestrant and estradiol alongside GAPDH protein levels as an internal gel loading control; Supplementary Figure 2 shows the rate of decreased detection by mass spectrometry of an estrogen receptor heavy isotype labelled peptide over time after treatment of cells with AZD9496, fulvestrant and tamoxifen and the calculated half life; Supplementary Figure 3 shows the degradation of estrogen receptor α by AZD9496, fulvestrant and estradiol in the presence of +/- 10 μM proteosomal inhibitor MG132; Supplementary Figure 4 contains a Western blot showing the re-emergence over 48 hours of estrogen receptor α following removal of AZD9496, fulvestrant and estradiol compounds from MCF-7 cells; Supplementary Figure 5 shows a bar chart of the measured estradiol levels in the blood of mice over 42 days after implantation of the mice with estrogen pellets to support growth of the MCF-7 cells as a tumour in mice; Supplementary Figure 6 shows the effects of AZD9496, fulvestrant and tamoxifen on mRNA levels of estrogen receptor regulated genes in vitro and in vivo; Supplementary Figure 7 shows the levels of estrogen receptor α protein remaining in tumours from the HCC1428 LTED model after treatment with AZD9496 and fulvestrant.…”

Data_Sheet_1_Characterization of Fructan Metabolism During Jerusalem Artichoke (Helianthus tuberosus L.) Germination.PDF by Jiao Jiao (297582)

“…Ht1-SST (sucrose:sucrose 1-fructosyl transferase, inulin synthesis initiator), and Ht1-FFT (fructan:fructan 1-fructosyl transferase, inulin elongator) expression generally decreased in indoor-grown T. The enzyme activities of 1-FEH and 1-FFT were unchanged during germination in both indoor- and field-grown T and BE/S, whereas 1-SST activity decreased in indoor-grown T, while 1-FEH and 1-FFT activities increased as a function of germination time in BE/S of both indoor- and field-grown tubers. …”

Autophagy presented substrates for gluconeogenesis. by Xiao-Pei Wang (6248303)

“…</b> Glucose levels in the hemolymph decreased after knockdown <i>Atg8</i>. <b>F and G.</b> FFAs levels in the hemolymph and glycerol levels in the fat body from 5th instar larvae to 8-day-old pupae. …”

Data_Sheet_1_Altered Insular Subregional Connectivity Associated With Cognitions for Distinguishing the Spectrum of Pre-clinical Alzheimer's Disease.pdf by Siyu Wang (696358)

“…A model consisting of altered insular subnetwork FCs in patients with aMCI was able to appropriately classify 86.5% of the patients with aMCI and CNs, with an AUC of 0.887, 80.4% sensitivity, and 83.6% specificity. …”

The Latitudinal Gradients of PID Species by Vanina Guernier (26588)

“…<div><p>(A) Relationship between PID species richness and latitude across the two hemispheres. …”

Smad3 Inactivation and MiR-29b Upregulation Mediate the Effect of Carvedilol on Attenuating the Acute Myocardium Infarction-Induced Myocardial Fibrosis in Rat by Jie-Ning Zhu (463126)

“…<div><p>Carvedilol, a nonselective β-adrenoreceptor antagonist, protects against myocardial injury induced by acute myocardium infarction (AMI). …”

Data_Sheet_1_Effects of Maternal Deprivation and Complex Housing on Rat Social Behavior in Adolescence and Adulthood.PDF by Jiska Kentrop (5736368)

“…Maternally deprived males – but not females – showed a longer latency to play and a decreased total amount of social play behavior, after a 24 h isolation period. …”

Glycogen Synthase Kinase 3beta Contributes to Proliferation of Arterial Smooth Muscle Cells in Pulmonary Hypertension by Piotr Sklepkiewicz (224302)

“…Constitutive activation of GSK3ß (GSK3ß S9A, 9th serine replaced to alanine) inhibited MCT-PASMCs proliferation by decreasing ERK phosphorylation.…”

The optimal disease management strategy depends on the relevant timeframe. by Nick P. Taylor (11888714)

“…Zero applications (no control) leads to higher severity (<b>A</b>) and lower yield (<b>B</b>) than two applications, although the difference reduces over time due to selection for resistant strains (<b>C</b>). …”

Factors associated with sexual satisfaction of men with spinal cord injury by Fernando Luiz Cardoso (4619239)

“…The programs SPSS (version 20.0) and R (version 3.3.1) were used for statistical analysis, respecting the range of 5%. Initially, we used the descriptive analysis through absolute and relative frequencies. …”

Cardiac function. by Gerald Yu Liao (20490394)

“…</b> Neither strain experienced age-related decreases in systolic/diastolic blood pressure, while CB6F1J mice trended higher readings compared to their C57BL/6J counterparts (*p < 0.05, **p < 0.01, N = 18-21/cohort for LVMI (tibia), N = 17-24/cohort for AO/LA ratio, N = 5-8/cohort for blood pressure).…”

Technological characterization of cookies made with different concentrations of mesquite flour during 120 days of storage by Rennan Pereira de Gusmão (4827588)

“…The quality parameters of the products were statistically analysed using a factorial experimental design with two factors, 9 stoarge periods and three cookie formulations. …”

Supplementary materials: Off-label antipsychotic use patterns among Texas Medicaid adults 2013–2016 by Shuang Chen (17729157)

“…<b>Results:</b> During 2013–2016, the prevalence of off-label antipsychotic use decreased from 22.5% to 17.4% and the proportions of no mental health diagnosis remained stable (7.3–9.4%). …”

Peptidomic Analysis of HEK293T Cells: Effect of the Proteasome Inhibitor Epoxomicin on Intracellular Peptides by Lloyd D. Fricker (104397)

“…Epoxomicin treatment decreased the levels of the majority of intracellular peptides, consistent with inhibition of the proteasome beta-2 and beta-5 subunits. …”

Bragg diffraction of higher orders on oblique helicoidal liquid crystal structures by H. Bogatyryova (18775989)

“…<p>For the oblique helicoidal (Ch_OH) structure of the chiral twist-bend nematic-forming mixture of CB7CB/CB6OCB/5CB doped by light-sensitive chiral compound based on azo-fragment, at oblique incidence of light two consequent states of Bragg reflection in the visible spectral range from 400 to 750 nm were experimentally observed in the course of decreasing the applied electric field. …”

Measures of [³H]-CQ uptake, ATP levels, and vesicle pH in untransformed, SEA-CRT-, and WT-CRT-transformed <i>Dictyostelium discoideum</i> whole cells. by Janni Papakrivos (318890)

“…<p>(<b>A</b>) Labeled drug uptake by <i>D. discoideum</i> cells in PB containing 100 nM [³H]-CQ and various concentrations of unlabeled CQ and ammonia. …”

Metformin delays tumor growth <i>in vivo</i>. by Julie Sesen (721048)

“…<p>(<b>A</b>) After tumor formation, mice were treated daily with IP injection of metformin (300mg/kg). …”

Lower-than-binomial variances under more limited mtDNA self-avoidance. by Robert C. Glastad (10692277)

“…Rows show different values of initial mutant proportion, with <i>h</i> = 0.1 in the top row and <i>h</i> = 0.5 in the bottom row. The three columns for each panel give decreasing network heterogeneity, expressed via different seed numbers, 4, 16 and 64 (more seed points give a more homogeneous network). …”

FEEDING AND REPRODUCTIVE ACTIVITY OF THE COPEPODS Drepanopus forcipatus AND Calanus australis DURING LATE SUMMER ON THE SOUTHERN PATAGONIAN SHELF (ARGENTINA, 47°-55°S) by Julieta Carolina Antacli (10476340)

“…Despite generally low feeding conditions and decreasing seasonal temperature, both copepods fed to some degree. …”