Carbonic Anhydrase Generates CO₂ and H⁺ That Drive Spider Silk Formation Via Opposite Effects on the Terminal Domains by Marlene Andersson (610369)

“…Surprisingly, the terminal domains respond in opposite ways when pH is decreased from 7 to 5: Urea denaturation and temperature stability assays show that NT dimers get significantly stabilized and then lock the spidroins into multimers, whereas CT on the other hand is destabilized and unfolds into ThT-positive β-sheet amyloid fibrils, which can trigger fiber formation. …”

Ameliorative impact of Juniperus Macrocarpa extract on methotrexate-induced hepatic damage in rats by Shahad Hassan Hadi (20141025)

“…Rats in groups 3 and 4 were given daily dosages of 100 mg and 200 mg of Juniperus macrocarpa aqueous extract, respectively, for two weeks before receiving a single intraperitoneal MTX injection. Juniperus macrocarpa extracts at both low and high doses substantially alleviated the MTX-provoked biochemical alterations, as evidenced by decreased levels of inflammatory parameters including TNF-α and IL-6 and hepatic enzymes including ALT, AST, and ALP. …”

Hydrogen in Drinking Water Reduces Dopaminergic Neuronal Loss in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine Mouse Model of Parkinson's Disease by Kyota Fujita (258978)

“…The concentration-dependency of H₂ showed that H₂ as low as 0.08 ppm had almost the same effect as saturated H₂ water (1.5 ppm). MPTP-induced accumulation of cellular 8-oxoguanine (8-oxoG), a marker of DNA damage, and 4-hydroxynonenal (4-HNE), a marker of lipid peroxidation were significantly decreased in the nigro-striatal dopaminergic pathway in mice drinking H₂-containing water, whereas production of superoxide (O₂•⁻) detected by intravascular injection of dihydroethidium (DHE) was not reduced significantly. …”

Table_1_Molecular Characterization of the Oncogene BTF3 and Its Targets in Colorectal Cancer.XLSX by Hantao Wang (760364)

“…Finally, miRNAs targeting BTF3 were predicted and validated. Decreased miR-497-5p expression is responsible for higher levels of BTF3 post-transcriptionally. …”

Feeding effects of cottonseed and its co-products on the meat proteome from ram lambs by Tiago do Prado Paim (5671568)

“…The effect of gossypol (a compound present in cotton co-products) in ruminant metabolism and meat quality is not yet clear. …”

Effect of <i>Trypanosoma cruzi</i> AP-1 γ subunit (TcAP1-γ) gene knockout on cruzipain expression and localization. by Claudia Maria do Nascimento Moreira (4287679)

“…In γKO epimastigotes, the levels of the zymogen form (57 kDa) of TcCZP were increased, while the levels of the mature enzyme (51 kDa) were decreased (to a faint band) compared with the WT. Labeling for the <i>T</i>. …”

Different expressions of immune components in ascites of early- and advanced-stage ovarian cancer patients. by Yu-Li Chen (126600)

“…C1, IL-4; C2, TNF-α; C3, TGF-β; C4, IL-6; C5, IL-10; C6, IFN-γ. <i>Note</i>: The IL-4 and TNF-α concentrations decreased while the TGF-β, IL-6, IL-10, and IFN-γ concentrations increased from early to advanced stage.…”

Table_3_Molecular Characterization of the Oncogene BTF3 and Its Targets in Colorectal Cancer.XLSX by Hantao Wang (760364)

“…Finally, miRNAs targeting BTF3 were predicted and validated. Decreased miR-497-5p expression is responsible for higher levels of BTF3 post-transcriptionally. …”

High-saturated fatty meals with orange juice intake have subjective appetite sensations suppressed: Acute, postprandial study by ALESSANDRA DA SILVA (10363904)

“…Methods: This acute, postprandial study included 39 healthy women (aged 20 to 40 years): 22 participants received a high-monounsaturated fat meal (MUFA) (≈1000 kcal, 56.3% Energy from MUFA) and 17 participants received a high-saturated fat meal (SFA) (≈1000 kcal, 37.6% Energy from SFA). …”

SDF-1α treatment induces reorganization of GM1- and flotillin-microdomains but does not affect DRM localization of flotillins in T cells. by Lawrence Rajendran (185591)

“…Increased ERK phosphorylation accompanied chemokine treatment at 5 min and decreases with time. <i>Lower panel</i>: Blotting with anti-ERK antibody shows the total ERK content.…”

CXCR4 regulates tumor progenitor cell adhesion. by Anna Dubrovska (105746)

“…The cells were counted in three wells per condition using a phase-contrast microscope.*-p value<0.05. (B) The expression level of α2, α5, and β3 integrins subunits is strongly upregulated in CD133⁺/CD44⁺ DU45 compared to CD133⁻/CD44⁻ DU45 cells. …”

Data_Sheet_1_Reproductive-dependent effects of B vitamin deficiency on lifespan and physiology.PDF by Guixiang Yu (17273653)

“…Notably, the dietary absence of VB₁, VB₃, VB₅, VB₆, or VB₇ significantly decreased the lifespan of wild-type females, yet demonstrated relatively little effect on ovo^D1 infertile mutant females’ lifespan. …”

Statin therapy reduces thrombus burden in stasis-induced murine VT. by Chase W. Kessinger (470740)

“…<p>Atorvastatin-treated and rosuvastatin-treated mice animals showed decreased thrombus mass at days 4, 7 and 10 compared to PBS (<b>A-D</b>). …”

Table_2_Inactivation of Prefrontal Cortex Delays Emergence From Sevoflurane Anesthesia.docx by Emma R. Huels (10321976)

“…Ninety minutes after injection, rats were anesthetized with 2.5% sevoflurane and the time to loss of righting reflex, a surrogate for loss of consciousness, was measured. …”

Novel Glycan Biomarkers for the Detection of Lung Cancer by James N. Arnold (2217103)

“…Lung cancer has a poor prognosis and a 5-year survival rate of 15%. …”

Image_1_Retinal Protection and Distribution of Curcumin in Vitro and in Vivo.TIF by Chiara B. M. Platania (5437685)

“…<p>Diabetic retinopathy (DR), a secondary complication of diabetes, is a leading cause of irreversible blindness accounting for 5% of world blindness cases in working age. …”

The 18-kDa Translocator Protein (TSPO) Disrupts Mammary Epithelial Morphogenesis and Promotes Breast Cancer Cell Migration by Xiaoting Wu (445800)

“…In addition, we found that combination treatment with the TSPO ligands (PK 11195 or Ro5-4864) and lonidamine, a clinical phase II drug targeting mitochondria, decreased viability of ER-negative breast cancer cell lines. …”

Unscreened Water-Diversion Pipes Pose an Entrainment Risk to the Threatened Green Sturgeon, <i>Acipenser medirostris</i> by Timothy D. Mussen (509438)

“…We examined avoidance behaviors and entrainment susceptibility of juvenile green sturgeon (35±0.6 cm mean fork length) to entrainment in a large (>500-kl) outdoor flume with a 0.46-m-diameter water-diversion pipe. …”

Table_2_Molecular Characterization of the Oncogene BTF3 and Its Targets in Colorectal Cancer.XLSX by Hantao Wang (760364)

“…Finally, miRNAs targeting BTF3 were predicted and validated. Decreased miR-497-5p expression is responsible for higher levels of BTF3 post-transcriptionally. …”

EFFECT OF SIZE OF INTESTINAL DIVERSIONS IN OBESE PATIENTS WITH METABOLIC SYNDROME SUBMITTED TO GASTRIC BYPASS by Rafael Jacques RAMOS (6378467)

“…In 24 months, there was a remission of systemic arterial hypertension in 65% of patients in group 1, 62.5% in group 2 and 68.4% in group 3. …”