DataSheet1_Period 2 Regulates CYP2B10 Expression and Activity in Mouse Liver.PDF by MengLin Chen (11747123)

“…Genotyping and Western blotting demonstrated loss of wild-type Per2 transcript and markedly reduced PER2 protein in Per2^Del4-6 mice. Hepatic expression of a plenty of drug-metabolizing genes (including Cyp2a4/2a5, Cyp2b10, Ugt1a1, Ugt1a9, Ugt2b36, Sult1a1 and Sult1e1) were altered (and majority were down-regulated) in Per2^Del4-6 mice. …”

Table_1_Effect of 15 days −6° head-down bed rest on microbial communities of supragingival plaque in young men.XLSX by Di Zhu (1450108)

“…</p>Methods<p>Sixteen healthy male volunteers were recruited, and supragingival plaque samples were collected under −6° head-down bed rest (HDBR) at five-time points: day 1 before HDBR; days 5, 10, and 15 of HDBR; and day 6 of recovery. …”

Associations among Erythroferrone and Biomarkers of Erythropoiesis and Iron Metabolism, and Treatment with Long-Term Erythropoiesis-Stimulating Agents in Patients on Hemodialysis by Hirokazu Honda (2964768)

“…<div><p>Background</p><p>We aimed to identify associations between erythroferrone (ERFE), a regulator of hepcidin 25, and biomarkers of erythropoiesis and iron metabolism. …”

The Chemopreventive Effects of Protandim: Modulation of p53 Mitochondrial Translocation and Apoptosis during Skin Carcinogenesis by Delira Robbins (244755)

“…<div><p>Protandim, a well defined dietary combination of 5 well-established medicinal plants, is known to induce endogenous antioxidant enzymes, such as manganese superoxide dismutase (MnSOD). …”

Effects of visual search training in children with hemianopia by Iliya V. Ivanov (3161901)

“…</p><p>Methods</p><p>22 children with HH (median age 11 years, 8 months: 6y6m-19y2m) trained at home for 15 minutes twice/day, 5 days/week, for 6 weeks. To assess performance before training (T1), directly after training (T2) and 6 weeks after the end of training (T3), we measured search times (STs) during on-screen search (with eye tracking), and in a real life search task. …”

Data_Sheet_3_Global Burden Attributable to High Low-Density Lipoprotein-Cholesterol From 1990 to 2019.docx by Heyue Du (11229207)

“…Background<p>High low-density lipoprotein-cholesterol (LDL-C) is a public health issue contributing to ischemic heart disease (IHD) and stroke.…”

Image_1_Empagliflozin Inhibits Hepatic Gluconeogenesis and Increases Glycogen Synthesis by AMPK/CREB/GSK3β Signalling Pathway.TIF by Xiaochen Yu (3796927)

“…<p>Increases in glucose production and decreases in hepatic glycogen storage induce glucose metabolic abnormalities in type 2 diabetes (T2DM). …”

Modified Taohong Siwu decoction improves cardiac function after myocardial ischaemia and reperfusion in rats by promoting endogenous stem cell mobilization and regulating metabolit... by Wan-ting Meng (13768659)

“…</p> <p>The high-dose modified THSWD group presented a reduced infarction area (decreased by 21.3%), decreased levels of lactate dehydrogenase and creatinine kinase, attenuated cell apoptosis, and enhanced superoxide dismutase activity in early stage I/R compared with other groups. …”

Image_1_The relationship of cervicothoracic mobility restrictions to fall risk and fear of falling in ankylosing spondylitis.tif by Janine L. Johnston (16450890)

“…Survival curves showed increased fall risk as cervical rotational amplitudes decreased.</p>Conclusion<p>In AS, decreased cervical rotations increase fall risk and fear of falling. …”

Drug-Tolerant Cancer Cells Show Reduced Tumor-Initiating Capacity: Depletion of CD44⁺ Cells and Evidence for Epigenetic Mechanisms by Hong Yan (27984)

“…Interestingly, drug-tolerant Du145 cells showed both increases and decreases in many “stemness” genes. Finally, evidence was provided that chronic drug exposure generated DTCs via epigenetic mechanisms involving molecules such as CD44 and KDM5A. …”

Image 2_The anti-depressive role of the Pei Yuan Kai Yu formula in cerebral small vessel disease based on gut microbiota.tif by Lixuan Yang (7331786)

“…Additionally, PY reversed inflammation-induced nerve damage; reduced the overexpression of microglia in the hippocampus; decreased the levels of hippocampal VEGF and MMP-9, and increased the levels of hippocampal occludin, ZO-1, and claudin-5. …”

Table3_Effects of Acute Exposure to Polystyrene Nanoplastics on the Channel Catfish Larvae: Insights From Energy Metabolism and Transcriptomic Analysis.XLSX by Qichen Jiang (381183)

“…<p>Microplastics (nanoplastics) pollution has been a major ecological issue threatening global aquatic ecosystems. …”

The effect of GIRK4 and RGS6 ablation on APD₈₀. by Kanchan Kulkarni (5029712)

“…<p>(A) Change in average APD₈₀ with decreasing BCL in WT, <i>Girk4</i>^<i>-/-</i>, and <i>Rgs6</i>^<i>-/-</i> hearts. (‘#’ denotes statistical significance of p < 0.05 between WT and <i>Girk4</i>^<i>-/-</i>. ‘$’ denotes statistical significance of p < 0.05 between WT and <i>Rgs6</i>^<i>-/-</i>). …”

Image7_Elabela Attenuates the TGF-β1-Induced Epithelial-Mesenchymal Transition of Peritoneal Mesothelial Cells in Patients Receiving Peritoneal Dialysis.TIF by Shunyun Xie (12898211)

“…Compared with those in patients with stage 5 chronic kidney disease who are not on dialysis, serum ELA levels in patients on PD increased with the improvement of residual renal function at PD duration <36 months and decreased to pre-dialysis levels at PD duration ≥36 months, suggesting that dialysis duration is the main risk factor affecting serum ELA levels in patients on PD. …”

Image3_Elabela Attenuates the TGF-β1-Induced Epithelial-Mesenchymal Transition of Peritoneal Mesothelial Cells in Patients Receiving Peritoneal Dialysis.tif by Shunyun Xie (12898211)

“…Compared with those in patients with stage 5 chronic kidney disease who are not on dialysis, serum ELA levels in patients on PD increased with the improvement of residual renal function at PD duration <36 months and decreased to pre-dialysis levels at PD duration ≥36 months, suggesting that dialysis duration is the main risk factor affecting serum ELA levels in patients on PD. …”

Dynamic Changes in Amino Acid Concentration Profiles in Patients with Sepsis by Longxiang Su (276106)

“…</p><p>Methods</p><p>Thirty-five critically ill patients with sepsis were included. …”

Image_2_Knockdown of LMTK3 in the Endometrioid Adenocarcinoma Cell Line Ishikawa: Inhibition of Growth and Estrogen Receptor α.tif by Guiyang Cai (11584636)

“…There was a positive correlation between the mRNA expression levels of LMTK3 and ESR1 (Spearman: P=2.011e-5, R=0.13; Pearson: P=7.18e-8, R=0.17). …”

Data Sheet 1_Constraint-based modeling of bioenergetic differences between synaptic and non-synaptic components of dopaminergic neurons in Parkinson’s disease.zip by Xi Luo (361139)

“…The synaptic PD model predicted a lower mitochondrial energy contribution and higher sensitivity to Complex I inhibition compared to the non-synaptic PD model. …”

Image_1_Effect of 15 days −6° head-down bed rest on microbial communities of supragingival plaque in young men.TIF by Di Zhu (1450108)

“…</p>Methods<p>Sixteen healthy male volunteers were recruited, and supragingival plaque samples were collected under −6° head-down bed rest (HDBR) at five-time points: day 1 before HDBR; days 5, 10, and 15 of HDBR; and day 6 of recovery. …”

Table1_Quantitative Reconstruction of Precipitation and Lake Areas During Early to Middle Holocene in Mu Us Desert, North China.docx by Dawei Li (5704)

“…Data also showed that the spatio-temporal pattern of the climate during the early to middle Holocene was relatively humid with a decreased precipitation gradient for millennia.…”