table1_Danggui-Shaoyao-San (DSS) Ameliorates Cerebral Ischemia-Reperfusion Injury via Activating SIRT1 Signaling and Inhibiting NADPH Oxidases.docx by Yunxia Luo (6661694)

“…We found that 1) ethanol extract of DSS, instead of aqueous extract, reduced infarct sizes and improved neurological deficit scores in the post-ischemic stroke rats; 2) Ethanol extract of DSS down-regulated the expression of the cleaved-caspase 3 and Bax, up-regulated bcl-2 and attenuated apoptotic cell death in the ischemic brains; 3) Ethanol extract of DSS decreased the production of superoxide and peroxynitrite; 4) Ethanol extract of DSS significantly down-regulated the expression of p67^phox but has no effect on p47^phox and iNOS statistically. 5) Ethanol extract of DSS significantly up-regulated the expression of SIRT1 in the cortex and striatum of the post-ischemic brains; 6) Co-treatment of EX527, a SIRT1 inhibitor, abolished the DSS’s neuroprotective effects. …”

Table_3_Gypenosides Prevent and Dissolve Cholesterol Gallstones by Modulating the Homeostasis of Cholesterol and Bile Acids.xls by Qian Zhuang (621842)

“…GPs increased the hepatic expression of genes encoding the cytochrome P450 (Cyp) enzymes Cyp7a1, Cyp7b1, and Cyp8b1, while decreasing the hepatic expression of genes encoding the adenosine triphosphate-binding cassette (Abc) transporters Abcg5 and Abcg8. …”

Polarity-Induced Reactive Wetting: Spreading and Retracting Sessile Water Drops by William S. Y. Wong (2795890)

“…Drops contacting the transition spread before retracting, occurring over the time scale of a few seconds. This phenomenon contradicts current understanding, exhibiting a uniquely (1) decreasing advancing contact angle and (2) increasing receding contact angle. …”

Data_Sheet_1_Human Recombinant Alkaline Phosphatase (Ilofotase Alfa) Protects Against Kidney Ischemia-Reperfusion Injury in Mice and Rats Through Adenosine Receptors.PDF by Diane L. Rosin (13165353)

“…Ilofotase alfa rescued CD73^–/– mice, which lack a 5′-ectonucleotidase that dephosphorylates AMP to adenosine; ZM241,385 inhibited that protection. …”

Pore networks to characterize formation damage due to fines at varied confinement and sand shape by Hannun, J.

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Evidence for home advantage in the time intervals between scores. by Haroldo V. Ribeiro (277883)

“…Here we have aggregated data from all seasons (see <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0152440#pone.0152440.s004" target="_blank">S3</a>, <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0152440#pone.0152440.s005" target="_blank">S4</a>, <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0152440#pone.0152440.s006" target="_blank">S5</a> and <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0152440#pone.0152440.s007" target="_blank">S6</a> Figs for individual results). …”

Kisspeptin expression by human term placenta. by Zahra Rasoulzadeh (2622283)

“…With purified Kp-10, anti-Kp-54/Kp-145 produced a single band at about 1.5 kDa, which is in good agreement with the theoretical MW for Kp-10-13. β-actin served as loading control. …”

Identification of SNP loci and candidate genes related to four important fatty acid composition in <i>Brassica napus</i> using genome wide association study by Qianglong Zhu (3614309)

“…<i>FAE1</i> and <i>BnaC</i>. <i>FAE1</i> on the A08 and C03 chromosomes, and other potential candidate genes involving in the fatty acid biosynthesis pathway, such as the orthologs genes of <i>FAD2</i>, <i>LACS09</i>, <i>KCS17</i>, <i>CER4</i>, <i>TT16</i> and <i>ACBP5</i>. …”

One Year of Enzyme Replacement Therapy Reduces Globotriaosylceramide Inclusions in Podocytes in Male Adult Patients with Fabry Disease - Fig 3 by Behzad Najafian (299389)

“…However, occasional podocytes showed no GL3 inclusions (Ø); <b>(C)</b>Total volume of GL3 inclusions per podocytes V(Inc/PC) was reduced after 11–12 months of ERT (p = 0.02); <b>(D)</b> Podocyte GL3 score (semiquantitative [<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0152812#pone.0152812.ref014" target="_blank">14</a>]) did not reduce significantly after 11–12 months (follow-up) of ERT (p = 0.18); <b>(E)</b> Podocyte volume significantly decreased after 11–12 months of ERT compared to baseline (p = 0.02). …”

Rate of ATP consumption by tumor cells can modulate the preference for aerobic glycolysis versus oxidative phosphorylation. by Shubham Tripathi (5479454)

“…The behavior shown is representative of that reported by te Boekhorst <i>et al</i>. [<a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1009841#pcbi.1009841.ref035" target="_blank">35</a>] (see <i>Fig 5E</i> therein). …”

DataSheet1_Case report: further delineation of AEBP1-related Ehlers–Danlos Syndrome (classical-like EDS type 2) in an additional patient and comprehensive clinical and molecular re... by Tomomi Yamaguchi (6843290)

“…A next-generation sequencing panel-based analysis revealed compound heterozygous variants in AEBP1: NM_001129.5:c.[2296G>T]; [2383dup], p.…”

Data_Sheet_1_Interaction of energy and sulfur microbial diet and smoking status with polygenic variants associated with lipoprotein metabolism.PDF by Haeng Jeon Hur (6808157)

“…The risk alleles of CETP_rs708272 and ALDH1A2_rs588136 were linked to increased expression in the heart and decreased in the brain, respectively. …”

Data Sheet 2_Bevacizumab and anlotinib combination therapy acts via HIF-1α suppression to exert synergistic anti-angiogenic and anti-tumor effects in non-small cell lung cancer.pdf... by Nafeisha Simayi (22262161)

“…B+A inhibited cell viability by 78%, colony formation by 90%, and invasion by 75% in NSCLC cell lines A549 and H1299; downregulated N-cadherin 5.34-fold, vimentin 6.46-fold, and α-SMA 4.35-fold; and upregulated E-cadherin 3.75-fold. …”

Nano-ciprofloxacin/meropenem exhibit bactericidal activity against Gram-negative bacteria and rescue septic rat model supplementary data by Safy Hadiya (9463872)

“…Synergy was evidenced for CS<b>/</b>Plu-Cip<b>/</b>Mer with a bactericidal effect (at 1<b>× </b>MIC and sub-MICs), and it significantly decreased bacterial load and rescued infected rats. …”

Data Sheet 1_Bevacizumab and anlotinib combination therapy acts via HIF-1α suppression to exert synergistic anti-angiogenic and anti-tumor effects in non-small cell lung cancer.zip... by Nafeisha Simayi (22262161)

“…B+A inhibited cell viability by 78%, colony formation by 90%, and invasion by 75% in NSCLC cell lines A549 and H1299; downregulated N-cadherin 5.34-fold, vimentin 6.46-fold, and α-SMA 4.35-fold; and upregulated E-cadherin 3.75-fold. …”

Data_Sheet_1_MiR-223-3p Alleviates Vascular Endothelial Injury by Targeting IL6ST in Kawasaki Disease.pdf by Xiang Wang (127867)

“…The values of IL-6, E-selectin, and ICAM-1 mRNA expressions decreased, while the value of IL-6ST was increased between the agonist treated mice and KD mice. …”

Data_Sheet_1_MiR-223-3p Alleviates Vascular Endothelial Injury by Targeting IL6ST in Kawasaki Disease.pdf by Xiang Wang (127867)

“…The values of IL-6, E-selectin, and ICAM-1 mRNA expressions decreased, while the value of IL-6ST was increased between the agonist treated mice and KD mice. …”

<i>pqn-59</i> depletion corrects the reduction of mature <i>lin-4</i> and <i>let-7</i> miRNA levels observed in <i>alg-1(0)</i> mutants and has little effect on the expression of c... by Colleen Carlston (11740725)

Viral RNA burden of disease-associated tissues was quantified using nucleocapsid qPCR. by Katherine S. Lee (13248894)

“…<p>Viral RNA was detectable in the lung tissue of challenged mice from both variants at both timepoints compared to no challenge (One-Way ANOVA, left to right: <i>P =</i> 0.0082, 0.0011, 0.0008, 0.0029) (A). In Nasal Wash, viral RNA burden increased from both variants at Day 2 compared to no challenge (One-Way ANOVA, <i>P =</i> 0.0016 Alpha; <i>P =</i> 0.0030 Delta) and was decreased at Day 6 for both variants from copy numbers at Day 2 (One-Way ANOVA, <i>P</i> = 0.0043 Alpha; <i>P =</i> 0.0019 Delta) with no statistical difference between variants at each time point (B). …”

Table 1_Global trends in esophageal cancer: sex and age disparities in health inequalities from 1990 to 2021, with projections to 2050.xlsx by Ying Liu (18461)

“…</p>Conclusion<p>Although projections indicate a decreasing trend, health inequalities have intensified. …”