DataSheet10_Mogrol Attenuates Osteoclast Formation and Bone Resorption by Inhibiting the TRAF6/MAPK/NF-κB Signaling Pathway In vitro and Protects Against Osteoporosis in Postmenopa... by Yongjie Chen (269938)

“…Furthermore, RT–PCR indicated that mogrol suppressed osteoclastogenesis-related gene expression, including CTSK, ACP5, MMP9 and DC-STAMP, in RANKL-induced bone marrow macrophages Western blotting demonstrated that mogrol suppressed osteoclast formation by blocking TNF receptor-associated factor 6 (TRAF6)-dependent activation of the mitogen-activated protein kinase nuclear factor-B (NF-κB) signaling pathway, which decreased two vital downstream transcription factors, the nuclear factor of activated T cells calcineurin-dependent 1 (NFATc1) and c-Fos proteins expression. …”

Measuring biological age to assess colony demographics in honeybees by Cedric Alaux (5176733)

“…This relationship was determined from a calibrated sample set of known-age bees and mathematically modelled for biological age prediction. …”

Image_2_Phenotype and function of MAIT cells in patients with alveolar echinococcosis.tif by Jintian Li (11679448)

“…Circulating MAIT exhibited activation and exhaustion phenotypes, and intrahepatic MAIT cells showed increased activation phenotypes with increased IFN-γ and IL-17A, and high expression of CXCR5 chemokine receptor. …”

Image_1_Phenotype and function of MAIT cells in patients with alveolar echinococcosis.tif by Jintian Li (11679448)

“…Circulating MAIT exhibited activation and exhaustion phenotypes, and intrahepatic MAIT cells showed increased activation phenotypes with increased IFN-γ and IL-17A, and high expression of CXCR5 chemokine receptor. …”

Image_1_Case report: Spontaneous lens absorption after the implantation of an implantable collamer lens.TIF by Xiaojing Liu (1282134)

“…The patient had undergone binocular ICL implantation for refractive correction of high myopia 1.5 years prior. Approximately 10 months later, he experienced a sudden loss of vision and pain in his left eye, which resolved spontaneously the next day without any treatment. …”

Image_6_Apolipoprotein-E deficiency leads to brain network alteration characterized by diffusion MRI and graph theory.JPEG by Margaret Caroline Stapleton (17437713)

“…<p>Late-onset Alzheimer’s disease (LOAD) is a major health concern for senior citizens, characterized by memory loss, confusion, and impaired cognitive abilities. …”

Image_1_D-Serine Contributes to Seizure Development via ERK Signaling.tif by Tie Ma (6505097)

“…L-aspartic acid β-hydroxamate (LaaβH), an inhibitor of SR, significantly prolonged the latencies of seizures, shortened the durations of seizures, and decreased the total EEG power in rats. In contrast, D-amino acid oxidase inhibitor 5-chlorobenzo[d]isoxazol-3-ol (CBIO), which can increase D-serine levels, showed the opposite effects. …”

Table_1_Effect of red meat, vegetable, tobacco, and alcohol consumption on national cancer mortality index: Data from 1989 to 2013 in 37 developed countries.XLSX by Myung-Bae Park (6842147)

“…According to the FEM, cancer death had statistically significant associations with education level (Coef = −0.022, P = 0.009), total health expenditure (Coef = −0.049, P = 0.000), aging rate (Coef = −0.178, P = 0.000), tobacco consumption (Coef = 0.096, P = 0.000), RM consumption (Coef = 0.107, P = 0.000), and vegetable consumption (Coef = −0.034, P = 0.000). A similar trend was also observed in the 3 and 5-year lagged models. …”

Table_1_Maternal High-Protein and Low-Protein Diets Perturb Hypothalamus and Liver Transcriptome and Metabolic Homeostasis in Adult Mouse Offspring.XLSX by Lisa J. Martin (228675)

“…Perinatal HP/LC and LP/HC exposures resulted in a decreased ability to clear glucose in the offspring, with reduced baseline insulin and glucose concentrations in the LP/HC group and a reduced insulin response post-glucose challenge in the HP/LC group. …”

Image_1_D-Serine Contributes to Seizure Development via ERK Signaling.tif by Tie Ma (6505097)

“…L-aspartic acid β-hydroxamate (LaaβH), an inhibitor of SR, significantly prolonged the latencies of seizures, shortened the durations of seizures, and decreased the total EEG power in rats. In contrast, D-amino acid oxidase inhibitor 5-chlorobenzo[d]isoxazol-3-ol (CBIO), which can increase D-serine levels, showed the opposite effects. …”

DataSheet2_Mogrol Attenuates Osteoclast Formation and Bone Resorption by Inhibiting the TRAF6/MAPK/NF-κB Signaling Pathway In vitro and Protects Against Osteoporosis in Postmenopau... by Yongjie Chen (269938)

“…Furthermore, RT–PCR indicated that mogrol suppressed osteoclastogenesis-related gene expression, including CTSK, ACP5, MMP9 and DC-STAMP, in RANKL-induced bone marrow macrophages Western blotting demonstrated that mogrol suppressed osteoclast formation by blocking TNF receptor-associated factor 6 (TRAF6)-dependent activation of the mitogen-activated protein kinase nuclear factor-B (NF-κB) signaling pathway, which decreased two vital downstream transcription factors, the nuclear factor of activated T cells calcineurin-dependent 1 (NFATc1) and c-Fos proteins expression. …”

Table 3_Speckle tracking technology and investigation of risk factors for premature ventricular contraction-induced cardiomyopathy.pdf by Qiao Ma (136536)

“…This study aimed to evaluate the diagnostic utility of speckle tracking echocardiography (STE)-derived strain parameters in patients with frequent PVCs and to identify associated risk factors for early myocardial impairment.</p>Methods<p>A total of 258 patients with monomorphic PVCs and a PVC burden >5% on 24 h Holter monitoring were enrolled, along with 80 age- and sex-matched healthy controls. …”

Table_8_Maternal High-Protein and Low-Protein Diets Perturb Hypothalamus and Liver Transcriptome and Metabolic Homeostasis in Adult Mouse Offspring.XLSX by Lisa J. Martin (228675)

“…Perinatal HP/LC and LP/HC exposures resulted in a decreased ability to clear glucose in the offspring, with reduced baseline insulin and glucose concentrations in the LP/HC group and a reduced insulin response post-glucose challenge in the HP/LC group. …”

Table_2_Plant Community Traits Respond to Grazing Exclusion Duration in Alpine Meadow and Alpine Steppe on the Tibetan Plateau.DOCX by Tianyu Zhan (8719563)

“…<p>Grazing exclusion has been a primary ecological restoration practice since the implement of “Returning Grazing Land to Grassland” program in China. …”

Mitochondria-Derived Reactive Oxygen Species Regulation of Tardigrade Osmobiosis Revealed by Proteomics of Hypsibius exemplaris by Evan R. Stair (17803878)

DataSheet_1_Gut microbiome variation in pulmonary TB patients with diabetes or HIV comorbidities.pdf by Portia Abena Morgan (11883253)

“…</p>Results<p>Compared to the healthy controls, the gut microbiome of all the TB cohorts was characterized by a significant decreased alpha diversity and significant compositional changes. …”

Image_1_Ductal Mucus Obstruction and Reduced Fluid Secretion Are Early Defects in Chronic Pancreatitis.jpeg by Anita Balázs (3239238)

“…Secretory mucins MUC6 and MUC5B were upregulated in human, Muc6 in mouse CP. …”

Image 1_Impact of social factors and health campaigns on the burden of idiopathic epilepsy: an inequality, decomposition, generalized and synthetic difference-in-differences study.... by Xuewen Rong (6242657)

“…The slope index of inequality for the mortality burden decreased from 1.97 to 1.62. After the policy shock, the age-standardized rate (ASR) of years lived with disability (YLD) in the Caribbean increased significantly to 4.59 (95% CI: 0.96 to 8.22), while the all-age YLD rate in the U.S. increased (5.18, 95% CI: 0.66 to 9.70) for both sexes.…”

Table_3_Relief of Cadmium-Induced Intestinal Motility Disorder in Mice by Lactobacillus plantarum CCFM8610.docx by Yang Liu (4829)

“…<p>Cadmium (Cd) is a toxic metal inducing a range of adverse effects on organs including liver and kidneys. …”

Data_Sheet_1_Genome-wide association study of coleoptile length with Shanxi wheat.docx by Naicui Wei (12000617)

“…In total, nine stable genetic loci were identified via 3VmrMLM under the three conditions, explaining 2.94–7.79% of phenotypic variation. Five loci on chromosome 2B, 3A, 3B, and 5B have not been reported previously. …”