Lysine succinylation of <i>Mycobacterium tuberculosis</i> isocitrate lyase (ICL) fine-tunes the microbial resistance to antibiotics by Mingliang Zhou (172233)

“…For the <i>in vitro</i> activity of the purified isocitrate lyase, only K189E mutant showed significantly decreased activity. Crystal structure analysis showed that Lys189 Glu dramatically increased the pKa of Glu188 and decreased the pKa of Lys190, whereas had negligible effect on other residues within 5 Å as well as disruption of the electrostatic interaction between Lys189 and Glu182, which might prevent the closure of the active site loop and cause severe reduction of the enzyme activity. …”

Hypoxia-Induced Modulation of Apoptosis and BCL-2 Family Proteins in Different Cancer Cell Types by Audrey Sermeus (37122)

“…In HepG2 cells that are strongly protected against cell death by hypoxia, hypoxia decreased the abundance of nearly all the pro-apoptotic BCL-2 family proteins while none of them are decreased in A549 cells that are not protected against cell death by hypoxia. …”

Elucidating the Molecular Mechanisms of Hederagenin-Regulated Mitophagy in Cervical Cancer SiHa Cells through an Integrative Approach Combining Proteomics and Advanced Network Asso... by Hao Sun (14095)

Impaired Bile Acid Homeostasis in Children with Severe Acute Malnutrition - Fig 2 by Ling Zhang (18071)

“…E) Fecal calprotectin is decreased in children to be discharged. Boxplots represent 25th and 75th quartiles, box-midline indicates median and whiskers define top and bottom values within 1.5 times the inter-quartile range (IQR). …”

Global positive effects of climate change on terrestrial soil methane emissions by Huili Feng (11658088)

“…These datasets were grouped into three separate files according to different types of climate manipulation: (i) increased temperature (Datasets S1), (ii) increased precipitation (Datasets S2), (iii) decreased precipitation (Datasets S3). The geographical scope of those research was between −37°25′ N and 69°45′ N latitude, with MAT between <a>−</a>11.5 °C and 26.4 °C and MAP between 158 mm and 2,539 mm. …”

Binding assays and secondary structure models for RNA molecules containing the Com binding sites. by Martyna Nowacka (6635225)

“…(B) EMSA confirmed that the Com binds RNA with </p><p>5ʹ-CC(N)_2-3GAG-3ʹ</p> motif. (C) Secondary structures of Com targets predicted by RNA structure [<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0214481#pone.0214481.ref027" target="_blank">27</a>] using reactivity from the SHAPE experiment as pseudo-free-energy constraints for RNA molecule alone (first molecule of each pair) and for the same RNA in the presence of Com (second molecule of each pair). …”

original data.rar by Yongjian Xiong (12099560)

“…<p>Inhibition of ferroptosis in intestinal epithelial <a>cells ameliorates clinical symptom</a> and improves endoscopic presentations in inflammatory bowel disease (IBD). …”

The effects of topical antimicrobial-corticosteroid combination therapy in comparison to topical steroids alone on the skin microbiome of patients with atopic dermatitis by Li Tingting (15257492)

“…AD lesions were characterized by a decreased sebum level, lower abundance of <i>Cutibacterium</i> and a higher abundance of <i>Staphylococcus</i>. …”

Autophagic flux modulation by Wnt/β-catenin pathway inhibition in hepatocellular carcinoma by Lilia Turcios (6392729)

“…We demonstrated that FH535 decreased HCC tumor progression in a mouse xenograft model. …”

HH01 violacein biosynthesis affects <i>C. elegans</i> survival and nematode development. by Claudia Hornung (199168)

“…<p>A) Decreased survival of <i>C. elegans</i> exposed to violacein-producing HH01. …”

Diabetes Prevalence in Sweden at Present and Projections for Year 2050 by Tomas Andersson (574816)

“…A dramatic reduction in incidence is required to prevent this development.…”

Table2_Case Report: C3 deficiency in two siblings.docx by Agustín Bernacchia (19204375)

“…Deficiencies in complement proteins, particularly C3, can lead to severe and recurrent infections as well as immune complex disorders. Here, we present a case report of two siblings with total C3 deficiency resulting from compound heterozygous mutations in C3 (NM_000064.4): c.305dup; [p.Asn103GlnfsTer66] and c.1269 + 5G>T, previously unreported in C3-related diseases. …”

Combined <em>In Silico</em> and <em>In Vivo</em> Analyses Reveal Role of <em>Hes1</em> in Taste Cell Differentiation by Masato S. Ota (265717)

“…Based on this analysis, we identified <em>Hes1</em> as a likely common regulatory factor, and examined its function <em>in vivo</em>. …”

Common findings on head computed tomography in neonates with confirmed congenital Zika syndrome by Natacha Calheiros de Lima Petribu (5995406)

“…In 15 neonates (93.7%), ventriculomegaly was observed. Colpocephaly was a common finding, being observed in 10 patients (62.5%). …”

Table 1_Staphylococcus epidermidis SAS1: new probiotic candidate for obesity and allergy treatment their mechanistic insights and cytotoxicity evaluation.docx by Sonia Sharma (3755452)

“…</p>Methods<p>: This probiotic candidate was isolated from a soil sample collected from a region of fruit waste decomposition. …”

Table 2_Staphylococcus epidermidis SAS1: new probiotic candidate for obesity and allergy treatment their mechanistic insights and cytotoxicity evaluation.docx by Sonia Sharma (3755452)

“…</p>Methods<p>: This probiotic candidate was isolated from a soil sample collected from a region of fruit waste decomposition. …”

Data Sheet 2_Multi-omic analysis of PBMCs in sepsis reveals widespread cytotoxic dysfunction and an increased population of CD69 expressing naïve CD4+ T cells.docx by Joshua Flynn (2544523)

“…A hallmark of sepsis is a deregulated inflammatory response to infection, with leukocytes playing a critical role.…”

Chronic Exposure to Low Frequency Noise at Moderate Levels Causes Impaired Balance in Mice by Haruka Tamura (153793)

“…Immunohistochemical analysis showed a decreased number of vestibular hair cells and increased levels of oxidative stress in LFN-exposed mice compared to those in non-exposed mice. …”

Table3_Case Report: C3 deficiency in two siblings.docx by Agustín Bernacchia (19204375)

“…Deficiencies in complement proteins, particularly C3, can lead to severe and recurrent infections as well as immune complex disorders. Here, we present a case report of two siblings with total C3 deficiency resulting from compound heterozygous mutations in C3 (NM_000064.4): c.305dup; [p.Asn103GlnfsTer66] and c.1269 + 5G>T, previously unreported in C3-related diseases. …”

Status of human cortex MS mRNA in autism. by Christina R. Muratore (380201)

“…(<b>B</b>) Cobalamin-binding domain PCR products for age-paired control (C) and autistic (A) subjects. Age-pairs were 5 and 4 years, 11 and 9 years and 30 years. …”