Video 1_Effect of Fangxia-Dihuang Decoction on doxorubicin-induced cognitive impairment in breast cancer animal model.mp4 by Xuan Wang (55634)

“…</p>Methods<p>Build 4T1 breast cancer xenograft tumor model in Balb/c mice, intraperitoneal injection of DOX (5mg/kg) once a week, build the model of DOX induced chemotherapy related cognitive impairment (CRCI), and the administration lasted for three weeks. …”

Image6_Arbuscular mycorrhizal fungi alleviate Mn phytotoxicity by altering Mn subcellular distribution and chemical forms in Lespedeza davidii.tif by Gao Pan (12510447)

“…</p>Methods<p>In this study, Lespedeza davidii inoculated with or without AMF (Glomus mosseae) under different Mn concentrations (0 mmol/L, 1 mmol/L, 5 mmol/L, 10 mmol/L, and 20 mmol/L) was cultivated via a pot experiment, and plant biomass, physiological and biochemical characteristics, manganese absorption, subcellular distribution, and chemical forms of Mn were examined.…”

Image 1_Efficacy and safety of leuprorelin (Boennuokang®) plus endocrine therapy in premenopausal women with HR+/HER2− breast cancer.tif by Xiuping Wu (527012)

“…During 24 months, the follicle-stimulating hormone level was decreased from 7.7 to 4.8 mIU/mL, and the luteinizing hormone level was decreased from 7.9 to 0.2 mIU/mL (both P < 0.001). …”

Image 2_Efficacy and safety of leuprorelin (Boennuokang®) plus endocrine therapy in premenopausal women with HR+/HER2− breast cancer.tif by Xiuping Wu (527012)

“…During 24 months, the follicle-stimulating hormone level was decreased from 7.7 to 4.8 mIU/mL, and the luteinizing hormone level was decreased from 7.9 to 0.2 mIU/mL (both P < 0.001). …”

Polymorphism in the abundance of the 3’–genic piRNAs in R strains. by Sergei Ryazansky (586294)

“…<p>(A) Heatmap shows RPKM (Reads Per Kilobase Million, only 24–29 nt reads were considered) corresponding to the most active 3’ genic piRNA clusters in follicular cells [<a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1006731#pgen.1006731.ref035" target="_blank">35</a>] in <i>Paris</i>, <i>Misy</i> and <i>w</i>^<i>K</i> strains relative to <i>iso-1</i> strain. …”

Relationship of body mass index and waist circumference with clinical outcomes following percutaneous coronary intervention by Yonggu Lee (436856)

“…Patients were evenly divided into 4 groups according to BMI (Q1_BMI, Q2_BMI, Q3_BMI and Q4_BMI) and WC (Q1_WC, Q2_WC, Q3_WC and Q4_WC).</p><p>Results</p><p>A total of 1,421 patients were observed for 5 years. …”

CEP164 regulates cell cycle progression and proliferation. by Gisela G. Slaats (648603)

“…<p>(A) RPE-FUCCI cells and their daughter cells were tracked by live cell imaging for 72 hours (hr) after transfection. …”

Key barriers and enablers associated with uptake and continuation of oral pre-exposure prophylaxis (PrEP) in the public sector in Zimbabwe: Qualitative perspectives of general popu... by Makaita M. Gombe (8294007)

“…Clients who opted for PrEP preferred it to other forms of HIV prevention. SDCs reported decreased condom use after PrEP initiation and in some cases were using PrEP while trying to conceive a child. …”

ACβ and PKA are both essential for parasite proliferation. by Avnish Patel (6393182)

“…Double-headed arrows represent the regions amplified by PCR in <a href="http://www.plosbiology.org/article/info:doi/10.1371/journal.pbio.3000264#pbio.3000264.s004" target="_blank">S4C Fig</a>. …”

Antimicrobial activity of RP-1 peptide conjugate with ferrocene group by Natalia C. S. Costa (8626206)

“…In comparison with amphotericin B, a second-line drug approved for leishmaniasis treatment, (IC₅₀ = 0.63 μmol L^-1), Fc-RP1 was more active and showed a 2.5-fold higher selectivity index. …”

Phosphorylation of Dzip1 by GSK3β promotes dissociation of Rab8^GDP from GDI2. by Boyan Zhang (501940)

“…<p>(A) The binding of Dzip1 with GDI2 is prevented by inhibition of GSK3. …”

Simulated currents of the voltage-gated potassium channels SHL-1, KVS-1, SHK-1, IRK-1/3, KQT-3, EGL-36 and EGL-2. by Martina Nicoletti (6900464)

“…The current inactivates exponentially with a time constant that is a decreasing function of voltage ( at 0 mV, <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0218738#pone.0218738.s003" target="_blank">S1 Fig</a>). …”

Functional Characterization of FLT3 Receptor Signaling Deregulation in Acute Myeloid Leukemia by Single Cell Network Profiling (SCNP) by David B. Rosen (104278)

“…Specifically, increased basal p-Stat5 levels, decreased FLT3L induced activation of the PI3K and Ras/Raf/Erk pathways, decreased IL-27 induced activation of the Jak/Stat pathway, and heightened apoptotic responses to agents inducing DNA damage were observed in FLT3-ITD AML samples. …”

Kmo inhibition or depletion impairs lysosome acidification in both exposed and infected macrophages. by Emily R. Goering (22486572)

“…<p>(<b>A</b>) Kmo inhibition with Ro61–8048 decreased maximum Lysotracker fluorescence in both infected and exposed bystander macrophages, which was restored upon treatment with exogenous 3-HK. …”

Table_1_Effects of Immobilized Antimicrobial Peptides on Growth Performance, Serum Biochemical Index, Inflammatory Factors, Intestinal Morphology, and Microbial Community in Weanin... by Nian Liu (29935)

“…The results showed the following: (1) compared with the CON group, the average daily gain in the whole experimental time (p < 0.05) was significantly increased, and the diarrhea rate of weaning piglets was decreased (p < 0.01) in the IAMPs group; (2) compared with the CON group, the concentrations of serum IgM and superoxide dismutase (SOD) in the IAMPs group were significantly higher than the CON and AB groups (p < 0.01); (3) compared with CON group, the concentrations of serum interleukin (IL)-10 and transforming growth factor (TGF-β) were significantly increased (p < 0.05), and the concentration of IL-12 was significantly decreased (p < 0.05) in the IAMPs group; (4) compared with CON group, the concentrations of serum endotoxin and D-lactate of piglets were significantly reduced (p < 0.05), and the relative expression of ZO-1 and occludin in the jejunum of piglets were significantly increased (p < 0.05) in the IAMPs group; (5) compared with the CON group, the villus height of the duodenum and jejunum of weaning piglets in IAMPs and AB groups was significantly increased (p < 0.05); and (6) compared with CON group, the relative abundance of Escherichia–Shigella in the colon and cecal digesta was decreased. …”

Regulation of amino acid and nucleotide metabolism by crustacean hyperglycemic hormone in the muscle and hepatopancreas of the crayfish <i>Procambarus clarkia</i> by Wenfeng Li (431916)

“…Finally, in the muscle, levels of several amino acids decreased significantly, while those of 5 other amino acids or related compounds significantly increased in response to CHH gene silencing. …”

Data_Sheet_1_Central and Obstructive Apneas in Heart Failure With Reduced, Mid-Range and Preserved Ejection Fraction.docx by Chiara Borrelli (6520607)

“…When stratified according to left ventricular EF, CA prevalence decreased (daytime: 57 vs. 43 vs. 42%, p = 0.001; nighttime: 66 vs. 48 vs. 34%, p < 0.0001) from HFrEF to HFmrEF and HFpEF, while OA prevalence increased (daytime: 5 vs. 8 vs. 18%, p < 0.0001; nighttime 20 vs. 29 vs. 53%, p < 0.0001).…”

Data_Sheet_1_Stress Response Simulated by Continuous Injection of ACTH Attenuates Lipopolysaccharide-Induced Inflammation in Porcine Adrenal Gland.PDF by Zhiyuan Sun (1668358)

“…Thirty-days-old Duroc × Landrace × Large White crossbred piglets (12 ± 0.5 kg) were randomly allocated into four groups in a 2 × 2 factorial arrangement of treatments, including ACTH pretreatment (with or without ACTH injection) and LPS challenge (with or without LPS injection). …”

Simulated dependence of [Ca²⁺] on electrical coupling following modulation of other K_ATP parameters. by Aleena M. Notary (625801)

“…<b>B).</b> As in A, for <i>g</i>_<i>coup</i> = 0pS. <b>C).…”

Defective optineurin causes autophagy failure. by Masaya Fukushi (216872)

“…(E) Autophagy flux after infection is shown as a decreased GFP/RFP ratio in parental (<i>n</i> = 4) and two <i>Optn</i>-KO clones (<i>n</i> = 4 each) of GFP-LC3-RFP-LC3ΔG MEFs infected with SeV (Cantell strain). …”