The co-opted function of cytosolic Pgk1 is to provide ATP for viral replicase complex assembly. by K. Reddisiva Prasanth (693252)

“…<p>(A) Northern blot analysis shows decreased TBSV (+) and (-)repRNA accumulation in a yeast strain (GALS::PGK1) when Pgk1 was depleted (raffinose) in comparison when Pgk1 expression is induced (Gal+Raf). …”

Pulmonary Abnormalities in Mice with Paracoccidioidomycosis: A Sequential Study Comparing High Resolution Computed Tomography and Pathologic Findings by Damaris Lopera (246539)

“…The experimental design used decreases the need to sacrifice a large number of animals, and serves to monitor treatment efficacy by means of a more rational approach to the study of human lung disease.…”

Image_2_Effect of Caloric Restriction on the in vivo Functional Properties of Aging Microglia.TIF by Maria Olmedillas del Moral (8771954)

“…The 6–12 months long caloric restriction (70% of ad libitum food intake) counteracted these aging-induced changes shifting many but not all functional properties of microglia toward a younger phenotype. …”

Examples of c-Fos immunostaining images obtained from the granular RC of the NC (A), 3H-B, (B), and 3H-B/T (C) groups by light microscopy. by Xiaoping Du (284656)

“…Four to six sections (8-12 images) from each rat brain (6 rats in each group) were used in this analysis. …”

Image_3_Effect of Caloric Restriction on the in vivo Functional Properties of Aging Microglia.TIFF by Maria Olmedillas del Moral (8771954)

“…The 6–12 months long caloric restriction (70% of ad libitum food intake) counteracted these aging-induced changes shifting many but not all functional properties of microglia toward a younger phenotype. …”

Data_Sheet_1_Effect of Caloric Restriction on the in vivo Functional Properties of Aging Microglia.pdf by Maria Olmedillas del Moral (8771954)

“…The 6–12 months long caloric restriction (70% of ad libitum food intake) counteracted these aging-induced changes shifting many but not all functional properties of microglia toward a younger phenotype. …”

Image_1_Effect of Caloric Restriction on the in vivo Functional Properties of Aging Microglia.pdf by Maria Olmedillas del Moral (8771954)

“…The 6–12 months long caloric restriction (70% of ad libitum food intake) counteracted these aging-induced changes shifting many but not all functional properties of microglia toward a younger phenotype. …”

Image_3_Effect of Caloric Restriction on the in vivo Functional Properties of Aging Microglia.TIFF by Maria Olmedillas del Moral (8771954)

“…The 6–12 months long caloric restriction (70% of ad libitum food intake) counteracted these aging-induced changes shifting many but not all functional properties of microglia toward a younger phenotype. …”

Inhibitory effect of K⁺ ions and influence of other ions and osmolality on the spermatozoa motility of European burbot (<i>Lota lota</i> L.) by Katarzyna Dziewulska (5227346)

“…A 6-mM KCl solution significantly decreased motility, and above 12-mM (50 mOsm kg^-1) totally ceased spermatozoa movement. …”

Table_1_Exploratory analysis on the relationship between dietary live microbe intake and arthritis: a national population based cross-sectional study.DOCX by Yiping Liu (2635054)

“…The restricted cubic spline plot was used to explore the relationship between the high dietary live microbe group and the odds of arthritis.</p>Results<p>12,844 participants were included in the present study. …”

Table_1_Effect of Caloric Restriction on the in vivo Functional Properties of Aging Microglia.pdf by Maria Olmedillas del Moral (8771954)

“…The 6–12 months long caloric restriction (70% of ad libitum food intake) counteracted these aging-induced changes shifting many but not all functional properties of microglia toward a younger phenotype. …”

Image_1_Effect of Caloric Restriction on the in vivo Functional Properties of Aging Microglia.TIF by Maria Olmedillas del Moral (8771954)

“…The 6–12 months long caloric restriction (70% of ad libitum food intake) counteracted these aging-induced changes shifting many but not all functional properties of microglia toward a younger phenotype. …”

Table_1_Effect of Caloric Restriction on the in vivo Functional Properties of Aging Microglia.pdf by Maria Olmedillas del Moral (8771954)

“…The 6–12 months long caloric restriction (70% of ad libitum food intake) counteracted these aging-induced changes shifting many but not all functional properties of microglia toward a younger phenotype. …”

Data_Sheet_1_Effect of Caloric Restriction on the in vivo Functional Properties of Aging Microglia.pdf by Maria Olmedillas del Moral (8771954)

“…The 6–12 months long caloric restriction (70% of ad libitum food intake) counteracted these aging-induced changes shifting many but not all functional properties of microglia toward a younger phenotype. …”

Image_2_Effect of Caloric Restriction on the in vivo Functional Properties of Aging Microglia.TIF by Maria Olmedillas del Moral (8771954)

“…The 6–12 months long caloric restriction (70% of ad libitum food intake) counteracted these aging-induced changes shifting many but not all functional properties of microglia toward a younger phenotype. …”

FLEXI interactions with RNA-binding proteins. by Jun Yao (9646)

“…RNA-binding sites: I, within introns corresponding to FLEXIs; SS-I and SS-E, bimodally enriched across the 5’- and 3’ splice sites in unspliced pre-mRNAs with the midpoints in the intron or flanking exon (SS-I and SS-E, respectively; Figs <a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1011416#pgen.1011416.g004" target="_blank">4A</a> and <a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1011416#pgen.1011416.s011" target="_blank">S11</a>). mRNA levels, RBPs whose knockdown resulted in significant difference in mRNA levels (increased or decreased, DESeq2 |LFC|≥1, adjusted p≤0.05) from host gene of FLEXIs with a binding site for that RBP compared to those genes whose transcripts lacked a binding site for the same RBPs based on ENCODE RBP-knockdown datasets (p≤0.05 calculated by Fisher’s exact test; <a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1011416#pgen.1011416.s013" target="_blank">S13 Fig</a>). …”

Norbornyl Cations of Group 14 Elements by Thomas Müller (3554)

“…In contrast, the intramolecular stabilization energy <i>E</i>_A of the norbornyl cations <b>4a</b>−<b>d</b> decreases, suggesting reduced interaction between the CC double bond and the electron-deficient element center in the plumbacation compared to the silacations. …”

LPS triggered chemotactic signaling through fAR1. by Miao Pan (5285834)

“…<p>(A) fAR1 possesses a VFT domain for ligand binding. …”

<i>P2RX7</i> ablation in <i>mdx</i> mice reduces macrophage infiltration. by Anthony Sinadinos (694160)

“…Significantly less F4/80 was found in Pf-<i>mdx</i>/P2X7^−/− and G-<i>mdx</i>/P2X7^−/− muscles compared to <i>mdx</i> muscles (Kruskal-Wallis H test, <i>H</i> = 7.73, df = 2, <i>n</i> = 4, <i>p</i> = 0.021; Mann-Whitney U test, Pf-<i>mdx</i>/P2X7^−/− versus <i>mdx</i>, <i>W</i> = 26.0, <i>n</i> = 4, <i>p</i> = 0.030; G-<i>mdx</i>/P2X7^−/− versus <i>mdx</i>, <i>W</i> = 26.0, <i>n</i> = 4, <i>p</i> = 0.030), while the ratio of F4/80 level to CD163 level, denoting M1/M2 macrophage ratio, was significantly reduced in Pf-<i>mdx</i>/P2X7^−/− muscles (Kruskal-Wallis H test, <i>H</i> = 8.77, df = 2, <i>n</i> = 4, <i>p</i> = 0.012; Mann-Whitney U test, <i>W</i> = 26.0, <i>n</i> = 4, <i>p</i> = 0.030). (D) A representative Western blot (top) illustrating decreased P2RX4 protein levels, and corresponding qPCR data (bottom) showing decreased expression of P2RX4 mRNA in Pf-<i>mdx</i>/P2X7^−/− gastrocnemius compared to <i>mdx</i> gastrocnemius (ANOVA, <i>F</i> = 25.96, df = 2, <i>n</i> = 5, <i>p <</i> 0.001; Tukey’s test, <i>mdx</i> versus C57, <i>p <</i> 0.001; Pf-<i>mdx</i>/P2X7^−/− versus <i>mdx</i>, <i>p</i> = 0.017; Pf-<i>mdx</i>/P2X7^−/− versus WT, <i>p</i> = 0.005). …”

TOP1α and UPF1 directly repress <i>TTG2</i>. by Chengxiang Li (5278343)

“…<p>(A) <i>TTG2</i> expression in pistils (left panel) or pollens (right panel) in different genetic backgrounds. …”