Bortezomib in combination with the PLK1 inhibitor BI 2536 induces a significant downregulation of the total levels and phosphorylation of Bcr-Abl, a decrease of downstream phosphorylated STAT5 and a caspase-dependent cell death in TKIs-resistant and –sensitive K562 cell lines. by Octavian Bucur (470431)

“…K562 and K562-R cells were treated with 9nM bortezomib and 8nM BI 2536 for 60h, followed by the detection of Bcr-Abl and phosphorylated STAT5. The combined treatment resulted in a marked decrease of the total levels of Bcr-Abl, which correlates with a decrease in the phosphorylation of the downstream STAT5 protein, in both K562 and K562-R cells. β-Actin was used as an internal loading control. …”

RNF5 loss decreases ERK and Akt activation, CDK1 and Smo expression and KSHV lytic replication in PEL cells. by Xiaojuan Li (351842)

TachypleginA treatment causes a decrease in the motor activity of the TgMyoA motor complex. by Aoife T. Heaslip (207534)

Transcriptional and translational markers of syncytialization and biochemical differentiation are significantly decreased by rotenone. by O’Llenecia S. Walker (8486163)

Establishment of HIV latency correlates with elevated amounts of AcH4 and Brd4 but drastically decreased AcH3 content on viral LTR. by Zichong Li (5131241)

Summary of DEGs in leaves and roots of <i>G</i>. <i>klotzschianum</i> upon salt stress. by Yangyang Wei (436909)

HDAC inhibitors block the proliferative rate of radial glia cells. by Yi Tao (178829)

“…<p>(A). Representative co-staining images showing the BrdU- and BLBP-positive cells in control (A1–A3), TSA-treated (50 nM, A4–A6) and VPA-treated (1 mM, A7–A9) tecta. …”

MVEC:AoAF interactions are dependent on signaling through ALK5. by Rebecca A. Scott (488956)

“…<p>(<b>A</b>) Representative images of microvascular tubules in 3:3 MVEC:AoAF co-cultures in degradable 7.5wt% hydrogels with 3 mM RGD after 14 days of culture with 1 μM A83-01 (ALK5 inhibitor) or DMSO (control). …”

Inhibition of PGAM5 and apoptosis alleviated the rTsSPc-damaged Caco-2 monolayer barrier integrity. by Qi Qi Lu (17721401)

Rotenone exposure decreases GSH level in porcine oocytes. by Geun Heo (14185618)

Salt stress responsiveness of a wild cotton species (<i>Gossypium klotzschianum</i>) based on transcriptomic analysis by Yangyang Wei (436909)

“…<i>klotzschianum</i>, we firstly detected the changes in hormones, H₂O₂ and glutathione (GSSH and GSH), then investigated the gene expression pattern of roots and leaves treated with 300 mM NaCl for 0, 3, 12, 48 h, and each time control by RNA-seq on the Illumina-Solexa platform. …”

Decrease in PP2A activity increases phosphorylation of p38MAPK, pMAPKAPK2 and Hsp27 in CD133+ cells. by Shih-Pei Lin (117914)

The effect of GCs on the number of OBs, OCs and MMs. by Minna Qiao (836556)

The effect of Lidamycin on the number of OBs, OCs and MMs. by Minna Qiao (836556)

A comparison of the experimental and simulated data after Lidamycin treatment. by Minna Qiao (836556)

A comparison of the experimental and simulated data after BHQ880 treatment. by Minna Qiao (836556)

The dynamics of OBs, OCs and MMs without drug treatment. by Minna Qiao (836556)

The effect of BHQ880 on the number of OBs, OCs and MMs. by Minna Qiao (836556)

The effects of BHQ880, GCs and Lidamycinon restoring the balance between OCs and OBs and killing MMs. by Minna Qiao (836556)

Synergy prediction of the combination of BHQ880, GCs and Lidamycin based on the Loewe combination index. by Minna Qiao (836556)