A New Rotane Family:  Synthesis, Structure, Conformation, and Dynamics of [3.4]-, [4.4]-, [5.4]-, and [6.4]Rotane¹ by Lutz Fitjer (2466634)

“…All syntheses are based on bicyclobutylidene (<b>9</b>):  [2+1] cycloaddition of cyclobutylidene yields [3.4]rotane (<b>5</b>) (<b>9</b>−<b>5</b>), [2+2] cycloaddition of trimethyleneketene followed by spiroalkylation of the resulting trispiroketone <b>10</b> yields [4.4]rotane (<b>6</b>) (<b>9</b>−<b>10</b>−<b>13</b>−<b>14</b>−<b>6</b>), homologization of <b>10</b> via β-hydroxy selenides gives access to tetraspiroketone <b>11</b> and pentaspiroketone <b>12</b> (<b>10</b>−<b>15</b>−<b>11</b>−<b>16</b>−<b>12</b>), and further elaboration directed toward a cyclopropylcarbene−cyclobutene rearrangement yields [5.4]rotane (<b>7</b>) and [6.4]rotane (<b>8</b>) [<b>11</b>(<b>12</b>)−<b>18</b>(<b>24</b>)−<b>19</b>(<b>25</b>)−<b>20</b>(<b>26</b>)−<b>21</b>(<b>27</b>)−<b>22</b>(<b>28</b>)−<b>23</b>(<b>29</b>)−<b>7</b>(<b>8</b>)]. …”

Celecoxib decreases the viability of MDA-MB-231-and MDA-MB-435-stable transfectants by Takeshi Sugimoto (84349)

Prb1 overexpression decreased APCs in ESCRT-mutant cells after nitrogen starvation. by Zulin Wu (4451572)

“…<p><b>A.</b> The accumulation of GFP-Atg8-labeled APCs in ESCRT- mutant (<i>snf7Δ</i>, <i>vps4Δ</i>) cells decreased with Prb1 overexpression. …”

Decreased cell growth of PGRN knock-out cell line as determined by the MTT assay. by Weifeng Zhang (134361)

Woven bone content is decreased at later stages of fracture healing in HFD-fed mice. by Matthew L. Brown (431187)

DHA combined with the glycolysis inhibitor decreases cell viability and induces apoptosis in NSCLC cells. by Yan-jun Mi (264759)

Jurkat and HeLa survival decreases with increasing electric field amplitude and pulse number. by Bennett L. Ibey (357053)

“…For all exposures, Jurkat cells are more sensitive than HeLa cells. Data points represent the average survival. (mean +/−s.e., n = 3–5).…”

MVEC viability is decreased over time in PEG-based hydrogels. by Rebecca A. Scott (488956)

Decreased expression of MHCII in antigen presenting cells from the lungs of IL-19-/- mice. by Carol Hoffman (196241)

Sodium taurocholate decreased higher order oligomerization. by Eunhee Lee (804130)

The effect of NAC on decreased ERK1/2 Tyr-204 phosphorylation caused by arecoline during myogenic differentiation in C2C12 cells. by Yi-Xuan Li (6633845)

I890T markedly decreases peak <i>I</i>_Na. by Anna Tarradas (105463)

Absence of PICALM results in a decreased rate of internalization and increased cell surface expression of TfR in MEFs. by Paula B. Scotland (138601)

Decreasing NR1 and NR2A gene expression in 5-, 14- and 21-day groups. by Chenxia Han (4020017)

ATG 5 down-regulation decreases human A53T ASYN-induced death in rat cortical neurons. by Maria Xilouri (264240)

Random forest model variable importance ranking by mean decrease in Gini value in the derivation dataset (<i>N</i> = 2,771). by Andrew F. Auld (8967719)

Blocking C5L2 decreased C5a-primed neutrophils for ANCA-induced respiratory burst. by Jian Hao (160736)

Decreased s.c. growth of CNDT 2.5 cells after systemic administration of DOPC liposome-conjugated siNRP-2. by Shaija Samuel (341436)

“…NRP-2-siRNA DOPC-treatment led to a significant decrease in tumor growth compared with cntr siRNA DOPC-treatment (264.4 mm³ vs. 751.3 mm³, respectively; *<i>p</i> = 0.01). …”

Establishment of HIV latency correlates with elevated amounts of AcH4 and Brd4 but drastically decreased AcH3 content on viral LTR. by Zichong Li (5131241)

Rank importance, where impairment at a point has a significant association with decreased vision-related quality of life. by Hiroshi Murata (387321)