Synthesis and Antiproliferative Activity of a New Series of Mono- and Bis(dimethylpyrazolyl)‑<i>s</i>‑triazine Derivatives Targeting EGFR/PI3K/AKT/mTOR Signaling Cascades by Ihab Shawish (13015516)

“…Compound <b>4f</b> exhibited potent EGFR inhibitory activity with an IC₅₀ value of 61 nM compared to that of Tamoxifen (IC₅₀ value of 69 nM), with EGFR inhibition of 83 and 84%, respectively, at a concentration of 10 μM. …”

Synthesis and Antiproliferative Activity of a New Series of Mono- and Bis(dimethylpyrazolyl)‑<i>s</i>‑triazine Derivatives Targeting EGFR/PI3K/AKT/mTOR Signaling Cascades by Ihab Shawish (13015516)

“…Compound <b>4f</b> exhibited potent EGFR inhibitory activity with an IC₅₀ value of 61 nM compared to that of Tamoxifen (IC₅₀ value of 69 nM), with EGFR inhibition of 83 and 84%, respectively, at a concentration of 10 μM. …”

AMPK activators reverse the decreased expression of GR induced by DEX in cultured prefrontal cortical astrocytes. by Shi-Ying Yuan (2937669)

“…<p>(A) Representative western blot images (upper) and summarized data (lower) showing the effects of AICAR (n = 5 for each group) (A), ASP (n = 4 for each group) (B), and MET (n = 7 for each group) (C) on DEX-induced decreases of GR and pAMPK in cultured astrocytes. …”

Exposure to glucocorticoids decreases the levels of pAMPK and GR in cultured rat prefrontal cortical astrocytes. by Shi-Ying Yuan (2937669)

Fluoxetine decreases TOPFlash firefly luciferase reporter activity. by Kentaro Miyamoto (123271)

HFD Developmentally Decreases B Lymphopoiesis: RT-PCR was performed on whole BM extracted from the femur. by Benjamin J. Adler (417336)

“…(c) Pax-5 expression, which represents an intermediate step in B lymphopoiesis did not appear reduced at 2D, but was significantly decreased subsequently. …”

Demographics, characteristics and comorbidities of patients hospitalized with a SARS-CoV-2 infection or COVID-19 diagnosis, total and stratified by rural/urban zip codes. by Sheri Denslow (13261919)

Initial vitals and labs of patients hospitalized with a SARS-CoV-2 infection or COVID-19 diagnosis, total and stratified by rural/urban zip codes. by Sheri Denslow (13261919)

<i>GSK-3β</i> −/− embryos exhibit decreased osteogenic gene expression in the palatine bones. by Emily R. Nelson (247130)

“…Scale bars in higher magnification images (second and fourth) represent 100 µm. (D) qRT-PCR of e15.5 <i>GSK-3β</i> +/+ and −/− embryos. <i>GSK-3β</i> −/− embryos display significantly decreased levels of the osteogenic genes <i>Alp</i>, <i>Runx2</i>, <i>Ocn</i>, and <i>Col1a1</i> by qRT-PCR, in comparison to wild-type littermates. …”

CNS-<i>Actb</i>KO mice exhibited hyperactivity and decreased performance in the Morris water maze. by Thomas R. Cheever (226943)

Sheet A in S5 Table:Sequences for primers and guide RNAs used in this study. by Tyron Chang (9922533)

A647D mutation decreases I_Na of WT and P1332L when co-expressed. by Jie Liu (15128)

HPLC chromatogram of standard NBD-C₁₂-FA. by Jae Kyo Yi (13570063)

The transcript and protein abundances of several VAC-residing proteases were decreased in Δ<i>crt</i>. by L. Brock Thornton (6808385)

Decreased 11ß-HSD1 protein level by IGF-I overexpression <i>in vivo</i> and a direct treatment with IGF-I. by Subrata Chowdhury (787208)

“…<p><b>A</b>. IGF-I overexpression decreased the levels of 11ß-HSD1 in pancreatic islets, liver and visceral fat, shown in Western blots. …”

Effects of ATP and primer-template binding on RecA-UmuC cross-linking efficiency in pol V Mut. by Angela J. Gruber (712958)

“…<p>Western blot using an antibody to UmuC demonstrating increased UmuC-RecA cross-linking with increasing ATPγS concentration and decreasing UmuC-RecA cross-linking with increasing primer-template concentration in the presence of 500 μM ATPγS. pol V Mut was generated using RecA N113Bpa as described in Methods, with ATPγS and primer-template hairpin DNA added where indicated. …”

Decrease in vRNA in brain during antiretroviral therapy. by Sonny R. Elizaldi (9684796)

Intraepithelial microneedle penetration of greater than 30% of the epidermis is required to establish detectable intra-epidermal infection in anogenital tissue. by Hafsa Rana (8201886)

SEM images (a) 5LZCM (b) 10LZCM (c) 15LZCM. by Md. Abu Daud (21485629)

“…AFM reveals the addition of the ZrO₂ decreasing roughness; the rms roughness of 5LZCM was 61.46 nm but the rms roughness was 37.12 nm for 15LZCM.…”

Hybrid Quantum/Classical Molecular Dynamics Simulations of the Proton Transfer Reactions Catalyzed by Ketosteroid Isomerase: Analysis of Hydrogen Bonding, Conformational Motions, a... by Dhruva K. Chakravorty (1420549)