Discovery of a Trifluoromethoxy Cyclopentanone Benzothiazole Receptor-Interacting Protein Kinase 1 Inhibitor as the Treatment for Alzheimer’s Disease by Yi Sun (118759)

“…<b>SZM679</b>, a highly specific RIPK1 inhibitor (<i>K</i>_d,RIPK1 = 8.6 nM, <i>K</i>_d,RIPK3 > 5000 nM), was developed by our group with superior high antinecroptotic activity (EC₅₀ = 2 nM), and investigated to completely reverse the tumor necrosis factor-induced systemic inflammatory response syndrome. …”

G-CSF decreased the number of IL- β expressing leukocytes. by Ryo Kadota (118698)

Decreased DG GCL volume of postnatal CRAF ko mice. by Verena Pfeiffer (158248)

Zinc exposure decreases NR1 clusters and NMDA currents. by Jia Zhu (135506)

“…Scale bar, 50 µm. (B) and (C) show the quantification of (A). …”

mTOR activity is decreased in KSR1-deficient T cells. by Marie Le Borgne (337225)

Overexpression of Jagn1 decreases steady-state insulin levels. by Courtney Nosak (1807867)

Acupuncture decreases the level of p-c-Jun after SCI. by Jee Y. Lee (455790)

PR-619 decreases Smad4 expression in UUO mice. by Kotaro Soji (5638613)

Knockout or inhibition of CCR1 decreases peritoneal inflammation and CAIA. by Nuruddeen D. Lewis (192385)

Lethal toxin decreases IL-22 production in human ILCs. by Sudarshan Seshadri (370894)

NE inhibits macrophage migration by decreasing CCR2 expression. by Fangming Xiu (315046)

The utility of Hmp for NO• consumption and tolerance decreases with increased NO• delivery rate. by Jonathan L. Robinson (409406)

2-APB decreased the expression of maturation markers in human DC. by Romain Félix (586765)

Decreased oligodendrocyte precursor number in developing white matter tracts. by Mark D. Grier (726986)

Decreased oxidative phosphorylation in SDH and VHL-related PH/PGL. by Judith Favier (78711)

“…(D–F) Mean values for mitochondrial complexes II+III, III and IV reveal a generalized decrease in respiration in SDH and VHL PH/PGL. …”

Caspase-1 activity in cell-extract decreases over time. by Obada R. Shamaa (830382)

ROCK inhibition decreases the motility of MHCC97H cells. by Ji-Gang Zhang (278184)

“…(<b>B</b>) and (<b>D</b>) Data were normalized to untreated cells and the relative migration or invasion is expressed as mean ± S.E. of triplicate experiments. Fewer cells migrated or invaded 48 h after incubation with Y27632 (50 µM), compared with the control cells, *<i>P</i><0.05, **<i>P</i><0.01 and ***<i>P</i><0.001.…”

ATRA decreased α-SMA expression in LT and HT cultures. by Carmen Retana (479628)

“…<p>(<b>A</b>) Immunofluorescence of omentum-derived mesothelial cells (control) and effluent-derived mesothelial cells from LT and HT grown until confluence in the presence of ATRA (0, 50 and 100 nM). …”

WT∶MU ratio is decreased in differentiated hOE-MSCs. by Nathalie Boone (234904)

Decrease in blood pressure by PP2, a Src inhibitor in <i>Csk</i>^+/- mice. by Hyeon-Ju Lee (796527)