DNA methylation associates with altered mRNA expression of key genes involved in NASH pathogenesis. by Sophie Grapentine (11794547)

“…(C) RT-PCR analysis of insulin, MAPK and JAK/STAT signalling pathways in 8-month-old <i>Pcyt2</i>^{<i> + /-</i>} mice shows altered DNA methylation influences the expression of genes within key pathways relevant to NASH pathogenesis. Genes that have a methylation increased or decreased of infinity are represented as Log2FC = 5.…”

Supplementary Material for: Demethylzeylasteral (T-96) Alleviates Allergic Asthma via Inhibiting MAPK/ERK and NF-κB Pathway by Huang J. (3231918)

“…Also, enhanced inflammatory infiltration and mucus hypersecretion were ameliorated in lungs of asthmatic mice following increasing doses of T-96 treatment, accompanied by decreased eosinophils in bronchoalveolar lavage fluid (BALF), IgE and OVA specific-IgE levels in serum and downregulated IL-5 and IL-13 expressions in BALF and lung tissues as well. …”

Table_1_Contributions of Individual, Family, and School Characteristics to Chilean Students’ Social Well-Being at School.DOCX by Verónica López (293471)

“…This study analyzed these joint contributions in a nationally representative sample of 6,389 children and adolescents enrolled in 5th–11th grades. …”

RIG-I Signaling Is Critical for Efficient Polyfunctional T Cell Responses during Influenza Virus Infection by Matheswaran Kandasamy (105167)

“…<div><p>Retinoic acid inducible gene-I (RIG-I) is an innate RNA sensor that recognizes the influenza A virus (IAV) RNA genome and activates antiviral host responses. …”

Image_1_The Impact of Body Mass Index Upon the Efficacy of Adalimumab in Hidradenitis Suppurativa.pdf by John W. Frew (7401773)

“…Descriptive, multivariable regression analysis and receiver operating characteristic (ROC) curves were calculated to assess the relationship between BMI and clinical outcome measures using R v3.5.3. Participants in the overweight and obese BMI category had reduced odds (58 and 67%, respectively) of achieving HiSCR [OR = 0.42 (95%CI −0.19, 0.91) p = 0.03], [OR = 0.33 (95%CI 0.16, 0.67) p = 0.002] compared to participants with BMI < 25. …”

Short-term effect of simulated salt marsh restoration by sand-amendment on sediment bacterial communities by François Thomas (216018)

“…Here, we analyzed samples from the same experiment to test the effect of sand-amendments on the microbial communities after 5 months. Along with the previously observed changes in biogeochemistry, sand amendments drastically modified the bacterial communities, decreasing richness and diversity. …”

Table_1_Chlorpromazine Efficiently Treats the Crisis of Pheochromocytoma: Four Case Reports and Literature Review.DOCX by James Jiqi Wang (11736326)

“…Chlorpromazine (25 or 50 mg) was injected intramuscularly, followed by continuous intravenous infusion (2–8 mg/h). The patients' BP decreased to 100–150/60–100 mmHg within 1–3 h and stabilized within 3–5 days. …”

Physiological and Molecular Alterations Promoted by <i>Schizotetranychus oryzae</i> Mite Infestation in Rice Leaves by Giseli Buffon (1392436)

Table_1_Characterization of Oxytocin Receptor Expression Within Various Neuronal Populations of the Mouse Dorsal Hippocampus.XLSX by W. Scott Young (8591811)

“…Outside of those excitatory neurons, over 90% of Oxtr-expressing neurons co-express glutamic acid decarboxylase-1 (Gad-1) with progressively decreasing numbers of co-expressing cholecystokinin, somatostatin, parvalbumin, neuronal nitric oxide synthase, the serotonin 3a receptor, the vesicular glutamate transporter 3, calbindin 2 (calretinin), and vasoactive intestinal polypeptide neurons. …”

Bone marrow stromal cell antigen 2(BST2) suppresses the migration and invasion of trophoblasts in preeclampsia by downregulating matrix metallopeptidase 2(MMP2) by Liu Jinyu (10938528)

“…<p>Preeclampsia is a grievous pregnancy-related complication with an incidence of approximately 5∼7% in pregnant women. …”

Table4_Integratively Genomic Analysis Reveals the Prognostic and Immunological Characteristics of Pyroptosis and Ferroptosis in Pancreatic Cancer for Precision Immunotherapy.XLSX by Ting Yu (156230)

“…A high P-F score was associated with active immune phenotype, decreased genomic alterations, and significantly longer survival. …”

Table8_Integratively Genomic Analysis Reveals the Prognostic and Immunological Characteristics of Pyroptosis and Ferroptosis in Pancreatic Cancer for Precision Immunotherapy.XLSX by Ting Yu (156230)

“…A high P-F score was associated with active immune phenotype, decreased genomic alterations, and significantly longer survival. …”

Model validation: autophagy inducers reduce TAU hyperphosphorylation and aggregation in TAU-P301L neurons. by An Verheyen (840523)

“…<b>(G, H)</b> AlphaLISA results reveal that trehalose significantly reduces hTAU10 (P<0,001) and AT8 TAU aggregation levels <i>versus</i> control (P = 0,006 at 31,5 mM and P = 0,014 at 125 mM). <b>(I, J)</b> Only at 125 mM of trehalose, both phosphorylated TAU (P<0,001, I) and total TAU levels (P<0,001, J) are decreased. …”

Inhibiting Spinal Neuron-Astrocytic Activation Correlates with Synergistic Analgesia of Dexmedetomidine and Ropivacaine by Huang-Hui Wu (541091)

“…</p><p>Results</p><p>i.t. Dex or Ropi displayed a short-term analgesia in a dose-dependent manner, and consecutive daily administrations of their combination showed synergistic analgesia and remarkably down-regulated neuronal and astrocytic activations indicated by decreases in the number of Fos-ir neurons and the GFAP expression within the SDH, respectively.…”

Data_Sheet_1_Exploring the Control in Antibacterial Activity of Silver Triangular Nanoplates by Surface Coating Modulation.docx by Jamila Djafari (6295301)

“…Several AgNT-coated nanomaterials, such as PVP (Polyvinylpyrrolidone) and MHA (16-mercaptohexadecanoic acid) as a stable organic coating system as well as uniform silica coating (≈5 nm) of AgNTs, have been prepared and fully characterized. …”

Loss of the HPV-Infection Resistance EVER2 Protein Impairs NF-κB Signaling Pathways in Keratinocytes by Françoise Vuillier (5657947)

“…Finally, we demonstrate that EVER2 loss induces constitutive PKCα-dependent c-jun phosphorylation and facilitates activation of the HPV5 long control region through a JNK-dependent pathway. …”

DataSheet_4_Single-Cell RNA Sequencing of Peripheral Blood Reveals Immune Cell Signatures in Alzheimer’s Disease.docx by Hui Xu (9203)

“…This study aimed to explore the molecular basis of peripheral immune cells and the features of adaptive immune repertoire at a single cell level. We profiled 36,849 peripheral blood mononuclear cells from AD patients with amyloid-positive status and normal controls with amyloid-negative status by 5’ single-cell transcriptome and immune repertoire sequencing using the cell ranger standard analysis procedure. …”

Effect of everolimus on precursor cell proliferation <i>in vivo</i> and <i>in vitro.</i> by Martine Dubois (257561)

“…The increase of neurosphere mean volume might be explained by an increased proportion of bigger neurospheres and a decreased proportion of smaller neurospheres associated with everolimus treatment.…”

Table_3_Physiological and molecular mechanisms of the response of roots of Pinus massoniana Lamb. to low-temperature stress.doc by Jingyu Lu (621174)

“…BAM, 4CL, CCoAOMT, PRX5, WRKYs, and hormone synthesis related genes play important roles. …”

FTI-277 treatment reversed burn-induced impaired insulin receptor (IR)-insulin receptor substrate-1 (IRS-1) signaling in skeletal muscle. by Harumasa Nakazawa (684211)

“…Insulin significantly increased p-IRS-1/GAPDH ratio and p-IRS-1/IRS-1 ratio in sham-burned mice and FTI-277-treated burned mice, whereas insulin failed to significantly increase p-IRS-1/GAPDH ratio or p-IRS-1/IRS-1 ratio in vehicle-treated burned mice (F, G). There was a trend of increase in insulin-stimulated p-IRS-1/IRS-1 ratio in vehicle-treated burned mice, but there was no statistical difference (G). n = 5 mice per group for saline-injected mice, n = 6 mice per group for insulin-injected sham-burned mice, n = 8 mice per group for insulin-injected burned mice. …”