Huntingtons Disease Mice Infected with <i>Toxoplasma gondii</i> Demonstrate Early Kynurenine Pathway Activation, Altered CD8+ T-Cell Responses, and Premature Mortality by David W. Donley (3111198)

“…<div><p>Huntington's disease (HD) is a progressive neurodegenerative disorder caused by a polyglutamine-repeat expansion in the huntingtin protein. …”

Image_1_Oxygen Variability During ENSO in the Tropical South Eastern Pacific.JPEG by Dante Espinoza-Morriberón (6235361)

“…The passage of intense remotely forced coastal trapped waves caused a strong deepening (shoaling) of the OMZ upper limit during EN (LN). …”

Data_Sheet_1_Effects of Climate Change vs. Grazing Exclusion on Species Diversity Over 18 Years Along an Elevation Gradient in the European Alps.PDF by Rüdiger Kaufmann (602291)

“…A total of 11 grazing exclusions were established. …”

Effect of IL-10 receptor (IL-10R) blockade upon leukomyelitis in Theiler’s murine encephalomyelitis virus (TMEV)-infected SJL mice. by Ann-Kathrin Uhde (3110976)

“…A,B: immunohistochemistry, bar = 20 μm. (C) Statistical analyses revealed a significant increase of CD3⁺ T cells in TMEV-infected mice with IL-10R blockade compared to isotype-treated animals at 49 dpi. …”

Table_1_Transcriptional changes in the gilthead seabream (Sparus aurata) skin in response to ultraviolet B radiation exposure.xlsx by Ricardo N. Alves (8839895)

“…S. aurata juveniles were exposed for 43 days to two experimental groups: 1) UVB (daily dose, 6 kJ m^-2; representing levels between 5 and 7 m depth); 2) Unirradiated treatment, used as a control. …”

Table_4_Regulatory Role of Hexokinase 2 in Modulating Head and Neck Tumorigenesis.xlsx by Wan-Chun Li (450324)

“…Loss of HK2 in HNSCC cells resulted in reduced cell (in vitro) and tumor (in vivo) growth, as well as decreased epithelial-mesenchymal transition–mediated cell movement; in contrast, HK2-deficient HNSCC cells exhibited greater sensitivity to chemotherapeutic drugs cisplatin and 5-fluorouracil but are more resistant to photodynamic therapy, indicating that HK2 expression could selectively define treatment sensitivity in HNSCC cells. …”

Data_Sheet_1_Threshold Reaction of Soil Arthropods to Simulative Nitrogen Deposition in Urban Green Spaces.pdf by Lingzi Mo (11645293)

“…Although higher doses of N addition showed adverse effects on soil fauna communities, low N inputs increased the soil fauna diversity and richness, especially at 5–10 cm depth. A threshold effect appears to exist: low N addition (<25 kg N ha^–1) did not negatively affect pedofauna structure and composition, while in the range from these values up to 50 kg N ha^–1, the composition of the soil fauna underwent major changes which were confirmed by the decline of biodiversity indices. …”

Fluorogenic Dimers as Bright Switchable Probes for Enhanced Super-Resolution Imaging of Cell Membranes by Ilya O. Aparin (4435837)

“…In these probes, the two cyanine units connected with a linker were modified at their extremities with low-affinity membrane anchors. …”

Data_Sheet_1_Threshold Reaction of Soil Arthropods to Simulative Nitrogen Deposition in Urban Green Spaces.pdf by Lingzi Mo (11645293)

“…Although higher doses of N addition showed adverse effects on soil fauna communities, low N inputs increased the soil fauna diversity and richness, especially at 5–10 cm depth. A threshold effect appears to exist: low N addition (<25 kg N ha^–1) did not negatively affect pedofauna structure and composition, while in the range from these values up to 50 kg N ha^–1, the composition of the soil fauna underwent major changes which were confirmed by the decline of biodiversity indices. …”

Supplementary Material for: How physicians and nursing staff perceive effectiveness and tolerability of Bryophyllum preparations: an online survey in an anthroposophic hospital by Huber T. (3218385)

“…Participants and Methods: All physicians and nursing staff with a valid email address at the hospital “Klinik Arlesheim AG” were invited via email to participate in this REDCap survey. …”

Image_1_Emerging Role of Dermal White Adipose Tissue in Modulating Hair Follicle Development During Aging.TIF by Jian Chen (15340)

“…Concomitantly, significantly decreased TNF-a, CCL2, IL-5, CSF2, and increased IL10 in dWAT was identified. …”

DKK1 Mediated Inhibition of Wnt Signaling in Postnatal Mice Leads to Loss of TEC Progenitors and Thymic Degeneration by Masako Osada (253586)

“…</p> <h3>Methodology/Principal Findings</h3><p>Here we demonstrate that tetracycline-regulated expression of the canonical Wnt inhibitor DKK1 in TECs localized in both the cortex and medulla of adult mice, results in rapid thymic degeneration characterized by a loss of ΔNP63⁺ Foxn1⁺ and Aire⁺ TECs, loss of K5K8DP TECs thought to represent or contain an immature TEC progenitor, decreased TEC proliferation and the development of cystic structures, similar to an aged thymus. …”

Image_1_Low-Dose Antibiotic Prophylaxis Induces Rapid Modifications of the Gut Microbiota in Infants With Vesicoureteral Reflux.JPEG by William Morello (10984251)

“…</p><p>Conclusions: In infants with VUR, even a short exposure to CAP definitely alters the GM composition, with increased relative abundance of opportunistic pathogens and decreased proportions of health-promoting taxa. …”

Type-Specific HPV Prevalence in Cervical Cancer and High-Grade Lesions in Latin America and the Caribbean: Systematic Review and Meta-Analysis by Agustín Ciapponi (202565)

“…The next five most common types, in decreasing frequency, were HPV 31, 58, 33, 45, and 52.…”

Table_1_Irisin alleviated the reproductive endocrinal disorders of PCOS mice accompanied by changes in gut microbiota and metabolomic characteristics.doc by Meina Yang (5437790)

“…However, the mechanism remains vague. Irisin, a novel myokine, plays a positive role in the mediating effects of physical activity.…”

Image1_Metabolic Consequences of Developmental Exposure to Polystyrene Nanoplastics, the Flame Retardant BDE-47 and Their Combination in Zebrafish.jpeg by Raphaël Chackal (12093191)

“…Conversely, molecular gene expression data pointed to a negative interaction, as co-exposure of high PS generally abolished the induction of gene expression in response to BDE-47. …”

Table_2_The changes and its significance of peripheral blood NK cells in patients with tuberculous meningitis.DOCX by Jie Mi (152887)

“…The proportion of TBM patients (48.7%) with a lower absolute count of NK cells than the normal reference value was significantly higher than that in NC (5.2%) and LTBI groups (4.0%) (p < 0.05), and slightly higher than that in NSTB group (36.0%) (p > 0.05). …”

DataSheet_1_Comprehensive transcriptomic analysis of age-, dark-, and salt-induced senescence reveals underlying mechanisms and key regulators of leaf senescence in Zoysia japonica... by Lanshuo Wang (15995294)

“…In addition, we experimentally validated the senescence regulatory function of seven TFs including ZjNAP, ZjWRKY75, ZjARF2, ZjNAC1, ZjNAC083, ZjARF1, and ZjPIL5 using a protoplast-based senescence assay. This study provides new insight into the molecular mechanisms underlying Z. japonica leaf senescence and identifies potential genetic resources for enhancing its economic value by prolonging its green period.…”

Data Sheet 1_Beyond salt tolerance: SOS1-13’s pivotal role in regulating the immune response to Fusarium oxysporum in Solanum phureja.docx by Liqin Liang (652560)

“…Furthermore, the expression of SA and JA response-related genes (NbPR5 and NbPR12) was up-regulated in NbSOS1-13-silenced plants.…”

Figures of manuscript "Fluvoxamine exerts anti-influenza(H1N1) effects through inhibiting apoptosis pathway" by Zhenqiao Wei (22372648)

“…This study evaluated the anti-influenza effects of fluvoxamine using H1N1-infected BALB/c mice and found that compared to the H1N1 infection group, the survival rate of mice in the fluvoxamine intervention group increased by 30% (50% <i>vs</i> 20%), with a decreased trend in body weight loss and improved lung tissue lesions. …”