Differences in Meiotic Recombination Rates in Childhood Acute Lymphoblastic Leukemia at an MHC Class II Hotspot Close to Disease Associated Haplotypes by Pamela Thompson (449563)

“…Of four haplotype blocks identified, predicted haplotypes in Block 1 (centromeric of <i>DNA3</i>) differed significantly between BCP-ALL and controls (P = 0.002) and in Block 4 (including <i>HLA-DPB1</i>) between T-ALL and controls (P = 0.049). Of specific common (>5%) haplotypes in Block 1, two were less frequent in BCP-ALL, and in Block 4 a single haplotype was more frequent in T-ALL, compared to controls. …”

Improved Muscle Function in Duchenne Muscular Dystrophy through L-Arginine and Metformin: An Investigator-Initiated, Open-Label, Single-Center, Proof-Of-Concept-Study by Patricia Hafner (479961)

“…Five ambulatory, genetically confirmed Duchenne muscular dystrophy patients aged between 7–10 years were treated with L-arginine (3 x 2.5 g/d) and metformin (2 x 250 mg/d) for 16 weeks. …”

Supplementary Material for: Genetical predicted causal relationship between gut microbiota and different types of kidney diseases by figshare admin karger (2628495)

“…Butyricicoccus, Catenibacterium, Flavonifractor, and Lachnospira were associated with an increased risk of membranous nephropathy, while RuminococcaceaeUCG011 was associated with a decreased risk of membranous nephropathy. Sensitivity analysis indicated the results were robust. …”

ImmTAC-mediated killing capacity is dependent on the levels of target antigen presentation. by Jane Harper (5855927)

“…NRQ = (RQ target gene/geometric mean RQ housekeeping genes) x 10⁴, RQ = Efficiency-CT. n = 3, 4, 5, 3 and 2 for Mel526, Mel624, MeWo, WM266-4 and A375, respectively. …”

The effects of acute administration of dexamfetamine on spontaneous swimming and on startle response. by Stefan Spulber (148803)

“…In larvae exposed to 1 mg/L PFOS, the amplitude of the startle response is not altered (presumably accounted for by more than one bout; see also D and E), but the duration of hyperactivity following the vibrational stimulation is shortened by both 1 and 10 µM dexamfetamine (see also <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0094227#pone.0094227.s005" target="_blank">Figure S5</a>). …”

Determination of gene expression signature for high microglia/macrophage infiltrate and association with cell-specific gene signatures and molecular subtypes. by Jane R. Engler (140558)

“…(<b>B</b>) Q-Q plot of genes differentially expressed in high microglia/macrophage tumors (n = 9) and low microglia/macrophage tumors (n = 9), as denoted in (A). (<b>C</b>) Unsupervised hierarchical clustering of adult GBMs (TCGA, n = 573), based on the six differentially expressed genes between high and low microglia/macrophage tumors as denoted in (A) and shown in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0043339#pone-0043339-t002" target="_blank">Table 2</a>, identified four distinct clusters (red, increased expression and green, decreased expression). …”

Improved HLA-class I restricted avidity of CD8αß expressing HA-2-TCR td CD4⁺ T-cells results in improved proliferation. by Marleen M. van Loenen (416496)

“…Histograms depict PKH dilution measured 5 days after stimulation, and a representative example of 2 independent experiments is depicted.…”

Computational modeling of Pavlovian response bias and instrumental learning bias. by Jennifer C. Swart (5870090)

“…The feedback sensitivity and learning rate were strongly anticorrelated over subjects (R = −0.77, <i>p</i> < 0.001) such that the impact of high feedback sensitivity was limited by a low learning rate. Subjects have increased learning rates for rewarded Go responses (ε₀ + κ) and decreased learning rates for punished NoGo responses (ε₀ − κ), which we refer to as the instrumental learning bias. …”

H3K27me3 ChIP-seq. by Dana Lau-Corona (8861900)

“…Also see <a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1008796#pgen.1008796.s014" target="_blank">S6A Table</a>. …”

Image 1_Multi-omics reveals effects of diet FNDF/starch level on growth performance and rumen development of Hu sheep.tif by Haibi Zhao (10869861)

“…Thirty-six male Hu sheep (2 months old) with similar weight [(10 ± 0.5) kg] were randomly divided into four groups of nine sheep each, and were divided into groups A (FNDF/starch = 0), B (FNDF/starch = 0.23), C (FNDF/starch = 0.56) and D (FNDF/starch = 1.10) with different FNDF/starch of pelleted rations, respectively. …”

Single-driver controllability of brain networks. by Remy Ben Messaoud (20521877)

“…Colors code for different systems. Values are shown for a representative subject. By decreasing <i>r</i> all values become positive and numerically reliable after a critical threshold <i>r</i>*. …”

Alteration in Endometrial Proteins during Early- and Mid-Secretory Phases of the Cycle in Women with Unexplained Infertility by Murli Manohar (423568)

“…The expression of Ras-related protein Rap-1b, Protein disulfide isomerase A3, Apolipoprotein-A1 (Apo-A1), Cofilin-1 and RAN GTP-binding nuclear protein (Ran) were found to be significantly increased, whereas, Tubulin polymerization promoting protein family member 3, Superoxide dismutase [Cu-Zn], Sorcin, and Proteasome subunit alpha type-5 were significantly decreased in mid- secretory phase endometrium of infertile women as compared to early-secretory phase endometrium of infertile women. …”

Data_Sheet_2_Features and Colonization Strategies of Enterococcus faecalis in the Gut of Bombyx mori.pdf by Xiancui Zhang (8349426)

“…In addition, the successful colonization of E. faecalis LX10 led to drastically increased expression of all adhesion genes (znuA, lepB, hssA, adhE, EbpA, and Lap), defense genes (cspp, tagF, and esp), regulation gene (BfmRS), secretion gene (prkC) and immune evasion genes (patA and patB), while the expression of iron acquisition genes (ddpD and metN) was largely unchanged or decreased. …”

Multivariable GEE linear modelling with exercise performance score as outcome, stratified by sex. by Amaya L. Bustinduy (214938)

“…a<p>Anemia based on WHO age-specific hemoglobin (Hb) criteria (19): for ages<12 yr, Hb<11.5 g/dL; for ages≥12 yr, Hb<12 g/dL; but for males≥15 yr, Hb<13 g/dL.…”

Variations of the <i>Escherichia coli</i> population in the digestive tract of broilers by Gwenaëlle Mourand (9435687)

“…The ESC-, gentamicin- and ciprofloxacin-resistant populations decreased over time. Isolates obtained during the first week contained a mean of 5.1 VAGs. …”

<i>Acetobacter thailandicus</i> stable association with <i>Drosophila melanogaster</i> is mutualistic. by Inês S. Pais (5484470)

“…<p>(A) Axenic 1–3-day-old <i>w</i>^<i>1118</i> <i>iso</i> males and females (G0) were in contact with an inoculum of 10⁵ CFU/μL of <i>Acetobacter</i> OTU2753, <i>A</i>. …”

The catalytic activity of cPLA₂α is required to support intra-Golgi transport. by Enrica San Pietro (259862)

“…(I–L) HeLa cells were loaded with bis-BODIPY FL C₁₁-PC (see <a href="http://www.plosbiology.org/article/info:doi/10.1371/journal.pbio.1000194#s4" target="_blank">Materials and Methods</a>) and fixed directly (I) or 15 min after incubation with either 5 µM ionomycin (J) or 1 µM pyrrolidine (K). …”

REPLICATION MATERIAL to Question-order Effect in the Study of Satisfaction with Democracy. Lessons from Three Split-ballot Experiments (Papp et al. 2024, Sociological Methodology) by Zsófia Papp (10573241)

“…(data3)</p><p dir="ltr">- World Values Survey Wave 5; Inglehart, R., C. Haerpfer, A. Moreno, C. Welzel, K. …”

The Soluble Guanylate Cyclase Stimulator Riociguat Ameliorates Pulmonary Hypertension Induced by Hypoxia and SU5416 in Rats by Michaela Lang (117542)

“…The aims of this study were to investigate the role of NO–sGC–cGMP signaling in a model of severe PAH and to evaluate the effects of sGC stimulation by riociguat and PDE5 inhibition by sildenafil on pulmonary hemodynamics and vascular remodeling in severe experimental PAH.…”

Data_Sheet_1_Effects of Supplemental Leucine on Growth, Nutrient Use, and Muscle and Visceral Tissue Mass in Holstein Bull Calves Fed Milk Replacer.docx by Jessica N. Reiners (12176384)

“…<p>To determine the effects of leucine supplementation on body weight (BW), tissue mass, nutrient digestibility, the concentration of serum amino acids (AAs) and metabolites, and protein abundance of elongation initiation factor 4E (eIF4E) in skeletal muscle, 23 Holstein bull calves (43. 3 ± 1.16 kg; 11.3 ± 0.57 days of age) fed milk replacer at 2.5% of body weight (BW; dry matter basis) were used in a randomized complete block design. …”