Data Sheet 6_The novel pleuromutilin derivative 22–((4-((4-nitrophenyl)acetamido)phenyl)thio)deoxy pleuromutilin possesses robust anti-mycoplasma activity both in vitro and in vivo... by Xirui Xia (12075476)

“…</p>Results<p>The results show that compound 16C has low toxicity (LD₅₀ > 5,000 mg/kg). Its pharmacokinetic profile is characterized by a short time to maximum concentration (Tmax = 0.24 h), high bioavailability (F = 71.29%), and short elimination half-life (T_1/2kel) (intramuscular and intravenous administration was 2.20 and 1.89 h, respectively). …”

Inhibition of glycolysis phenocopies the yeast-dependent modulation of arousal threshold. by Elizabeth B. Brown (4582978)

“…(G) Although there is a significant effect of treatment arousal threshold (REML: F_1,121 = 5.426, <i>P</i><0.0231, N = 46–51), <i>post hoc</i> analyses revealed no evidence of a homeostatic rebound for any timepoint measured (0–3 hrs: <i>P</i> = 0.3274; 0–6 hrs: <i>P</i> = 0.0822; 0–12 hrs: <i>P</i> = 0.4670). …”

Image_12_Modulatory actions of Echinococcus granulosus antigen B on macrophage inflammatory activation.tif by Ana Maite Folle (3613004)

“…., one of these lipoproteins is antigen B (EgAgB), codified by a multigenic and polymorphic family that gives rise to five gene products (EgAgB8/1-5 subunits) assembled as a 230 kDa macromolecule. …”

Table1_QiShenYiQi Pill Ameliorates Cardiac Fibrosis After Pressure Overload-Induced Cardiac Hypertrophy by Regulating FHL2 and the Macrophage RP S19/TGF-β1 Signaling Pathway.XLSX by Gulinigaer Anwaier (6903299)

“…QSYQ also inhibited the following: release of RP S19 from the injured myocardium, activation of C5a receptors in monocytes, polarization of macrophages, and release of TGF-β1. …”

Excessive plasmin activity is detected around rupture-prone <i>Chd4^fl/fl;Tie2-Cre⁺</i> blood vessels. by Kyle G. Ingram (496731)

“…<p>(A–D) Representative images of E10.5 littermate control (A,B) and <i>Chd4^fl/fl;Tie2-Cre⁺</i> (C,D) dorsal aortae (DA) subjected to in situ zymography for detection of plasmin activity. …”

CDC-42 activation at the invasive membrane is dependent on vulval precursor cells. by Lauren L. Lohmer (845682)

“…<p>(A) Fluorescence images of a biosensor that reports active, GTP-bound CDC-42 (left; <i>cdh3>GFP</i>::<i>GBD</i>_<i>wsp-1</i>) and F-actin (middle; <i>cdh3>mCherry</i>::<i>moeABD</i>) overlaid on DIC image (right). …”

Image 1_The novel pleuromutilin derivative 22–((4-((4-nitrophenyl)acetamido)phenyl)thio)deoxy pleuromutilin possesses robust anti-mycoplasma activity both in vitro and in vivo.jpeg... by Xirui Xia (12075476)

“…</p>Results<p>The results show that compound 16C has low toxicity (LD₅₀ > 5,000 mg/kg). Its pharmacokinetic profile is characterized by a short time to maximum concentration (Tmax = 0.24 h), high bioavailability (F = 71.29%), and short elimination half-life (T_1/2kel) (intramuscular and intravenous administration was 2.20 and 1.89 h, respectively). …”

Table_1_Sperm DNA Hypomethylation Proximal to Reproduction Pathway Genes in Maturing Elite Norwegian Red Bulls.XLSX by Abdolrahman Khezri (8055263)

“…Most of the identified DMRs (69%) exhibited a less than 10% methylation difference while only 1.5% of DMRs exceeded a 25% methylation difference. …”

Image_1_Upregulation of Extracellular Vesicles-Encapsulated miR-132 Released From Mesenchymal Stem Cells Attenuates Ischemic Neuronal Injury by Inhibiting Smad2/c-jun Pathway via A... by Bin Feng (108287)

“…<p>Ischemic cerebrovascular disease is a significant and common public health issue worldwide. …”

Knockdown of mDia formins impairs oocyte maturation and spindle formation. by Hak-Cheol Kim (716627)

“…</b> Knockdown of mDia1, mDia2, or mDia1 + mDia2 decreases the oocyte maturation rate and increases the symmetric division rate. dsRNA against mDia1, mDia2, or a mixture of mDia1 and mDia2 were microinjected into immature oocytes along with control dsRNA and cells were cultured for 12 h after which their status of development was assessed. …”

Table_2_Protective Effects of Abrus cantoniensis Hance on the Fatty Liver Hemorrhagic Syndrome in Laying Hens Based on Liver Metabolomics and Gut Microbiota.DOCX by Xu Liu (276996)

“…FLHS model of laying hens was induced by a high-energy low-protein (HELP) diet, and ACD (0.5, 1, 2 g ACD/hen per day) was given to the hens in drinking water at the same time for 48 days. …”

Data Sheet 2_The novel pleuromutilin derivative 22–((4-((4-nitrophenyl)acetamido)phenyl)thio)deoxy pleuromutilin possesses robust anti-mycoplasma activity both in vitro and in vivo... by Xirui Xia (12075476)

“…</p>Results<p>The results show that compound 16C has low toxicity (LD₅₀ > 5,000 mg/kg). Its pharmacokinetic profile is characterized by a short time to maximum concentration (Tmax = 0.24 h), high bioavailability (F = 71.29%), and short elimination half-life (T_1/2kel) (intramuscular and intravenous administration was 2.20 and 1.89 h, respectively). …”

Deep Phylogenetic Analysis of Haplogroup G1 Provides Estimates of SNP and STR Mutation Rates on the Human Y-Chromosome and Reveals Migrations of Iranic Speakers by Oleg Balanovsky (31853)

“…The haplotype diversity, which decreased from West Iran to Central Asia, allows us to hypothesize that this rare haplogroup could have been carried by the expansion of Iranic speakers northwards to the Eurasian steppe and via founder effects became a predominant genetic component of some populations, including the Argyn tribe of the Kazakhs. …”

Double-Blind Controlled Randomized Trial of Cyclophosphamide versus Methylprednisolone in Secondary Progressive Multiple Sclerosis by Bruno Brochet (530833)

“…Patient with SPMS, with a documented worsening of the Expanded Disability Status Scale (EDSS) score during the last year and an EDSS score between 4·0 and 6·5 were recruited and received one intravenous infusion of treatment (CPM: 750 mg /m² body surface area—MP: 1g) every four weeks for one year, and every eight weeks for the second year. …”

Image_1_Time-restricted feeding affects colonic nutrient substrates and modulates the diurnal fluctuation of microbiota in pigs.TIF by Hongyu Wang (366946)

“…</p>Results<p>Results showed that TRF altered the distribution of feed intake without changing the total feed intake within a day (p = 0.870). TRF decreased the overall concentration of colonic cellulose and altered their oscillating patterns. …”

DataSheet_1_Ovarian Hyperstimulation Syndrome (OHSS) requiring Intensive Care Unit (ICU) admission between 1996-2020 in England, Wales, and Northern Ireland.docx by Ali Abbara (7311647)

“…</p>Discussion<p>Although absolute rates of OHSS requiring ICU admission recorded in this study are likely to represent a significant underestimate of all clinically significant OHSS, rates of OHSS requiring ICU admission have decreased since 1996 in concordance with the introduction of modern IVF practices.…”

Image_7_Modulatory actions of Echinococcus granulosus antigen B on macrophage inflammatory activation.jpeg by Ana Maite Folle (3613004)

“…., one of these lipoproteins is antigen B (EgAgB), codified by a multigenic and polymorphic family that gives rise to five gene products (EgAgB8/1-5 subunits) assembled as a 230 kDa macromolecule. …”

Image_2_Upregulation of Extracellular Vesicles-Encapsulated miR-132 Released From Mesenchymal Stem Cells Attenuates Ischemic Neuronal Injury by Inhibiting Smad2/c-jun Pathway via A... by Bin Feng (108287)

“…<p>Ischemic cerebrovascular disease is a significant and common public health issue worldwide. …”

Image_9_Modulatory actions of Echinococcus granulosus antigen B on macrophage inflammatory activation.jpeg by Ana Maite Folle (3613004)

“…., one of these lipoproteins is antigen B (EgAgB), codified by a multigenic and polymorphic family that gives rise to five gene products (EgAgB8/1-5 subunits) assembled as a 230 kDa macromolecule. …”

Table_1_Protective Effects of Abrus cantoniensis Hance on the Fatty Liver Hemorrhagic Syndrome in Laying Hens Based on Liver Metabolomics and Gut Microbiota.XLSX by Xu Liu (276996)

“…FLHS model of laying hens was induced by a high-energy low-protein (HELP) diet, and ACD (0.5, 1, 2 g ACD/hen per day) was given to the hens in drinking water at the same time for 48 days. …”