Insights from the Fungus <em>Fusarium oxysporum</em> Point to High Affinity Glucose Transporters as Targets for Enhancing Ethanol Production from Lignocellulose by Shahin S. Ali (277910)

“…Its expression level decreased with increasing glucose concentration in the medium and in a glucose uptake study the Km_(glucose) was 0.9 mM, which indicated that the protein is a high affinity glucose transporter. …”

Image_4_Yin-Chen-Hao Tang Attenuates Severe Acute Pancreatitis in Rat: An Experimental Verification of In silico Network Target Prediction.JPEG by Hong Xiang (739659)

“…YCHT administration produced the following results: (1) significantly inhibited the secretion of pancreatic enzymes and protected pancreatic tissue; (2) obviously increased the number of in situ terminal deoxynucleotidyl transferase dUTP nick-end labeling (TUNEL)-positive cells and induced apoptosis; (3) markedly inhibited neutrophil infiltration to the impaired pancreas and reduced the inflammatory reaction; (4) notably enhanced the activities of antioxidant enzymes and decreased the nitric oxide synthase levels; (5) significantly reduced the levels of triglycerides, total cholesterol and low-density lipoprotein and increased high-density lipoprotein; and (6) significantly up-regulated peroxisome proliferator-activated receptor-γ (PPARγ) and down-regulated nuclear factor-kappa B (NF-κB). …”

Data_Sheet_1_The Expression of NOX From Synthetic Promoters Reveals an Important Role of the Redox Status in Regulating Secondary Metabolism of Saccharopolyspora erythraea.docx by Xiaobo Li (118828)

“…In contrast, the lower redox ratio resulted in a decreased production of another secondary metabolite, the reddish pigment 7-O-rahmnosyl flaviolin. …”

Metabolomics normalized ion counts in M9. by Jisun Kim (837555)

“…These differences were also evident through unbiased metabolomics studies and ¹³C labeling experiments that showed mutation of <i>pgl</i> led to reductions in pyrimidine metabolism including decreases in ribose-5P, UMP and GMP. These nucleotide reductions impacted the amount of extracellular DNA in biofilms and reduced biofilm formation. …”

Table 2_Evaluating two live-attenuated vaccines against Salmonella enterica serovar Reading in turkeys: reduced tissue colonization and cecal tonsil transcriptome responses.xlsx by Melissa S. Monson (8281047)

“…Gene expression of intestinal transporters (such as SCNN1B and SLC10A2) and tight junction proteins was significantly decreased in the turkey cecal tonsil transcriptome at 2 DPI with S. …”

Image2_Modified Iron Deposition in Nigrosomes by Pharmacotherapy for the Management of Parkinson’s Disease.JPEG by Mengdi Wang (5526545)

“…The loss of the nigrosome on SWI was clearly inhibited in PD patients with a 3–5-year duration of administration of antiparkinson medications compared with no treatment. …”

Nuclear Jacob Regulates the Phosphorylation of CREB by Daniela C Dieterich (80097)

“…Scale bar indicates 40 μm.</p> <p>(A and B) Overexpression of Δ<i>Myr-Jacob-GFP</i> decreases the basal level of CREB phosphorylation in nonstimulated primary hippocampal cultures (DIV12). …”

Inhibition of Transforming Growth Factor-Activated Kinase 1 (TAK1) Blocks and Reverses Epithelial to Mesenchymal Transition of Mesothelial Cells by Raffaele Strippoli (181125)

“…Analysis of signalling pathways downstream of TAK1 involved in EMT induction, showed that TAK1 inhibition reduced the transcriptional activity of NF-κB and Smad3, as well as the phosphorylation of c-jun, while enhancing Smad1–5–8 activity. These results demonstrate that TAK1 is a cross-point in a network including different pro-EMT transcription factors, such as NF-κB, Snail, AP-1 and Smads. …”

Metabolomics normalized ion counts. by Jisun Kim (837555)

“…These differences were also evident through unbiased metabolomics studies and ¹³C labeling experiments that showed mutation of <i>pgl</i> led to reductions in pyrimidine metabolism including decreases in ribose-5P, UMP and GMP. These nucleotide reductions impacted the amount of extracellular DNA in biofilms and reduced biofilm formation. …”

Image_3_Differential Profile of Systemic Extracellular Vesicles From Sporadic and Familial Alzheimer’s Disease Leads to Neuroglial and Endothelial Cell Degeneration.TIFF by Juan Villar-Vesga (4900768)

“…Two distinct forms of Alzheimer disease (AD) are known: a late-onset sporadic form (SAD) and an early-onset familial form (FAD). …”

Elk1 affects katanin and spastin proteins via differential transcriptional and post-transcriptional regulations by Dolunay Kelle (6388055)

“…In this study, we identified the main regulatory region of <i>KATNA1</i> gene encoding katanin-p60 as 5’ UTR, which has a key role for its expression, and showed Elk1 binding to <i>KATNA1</i>. …”

DataSheet1_Prognostic Value and Therapeutic Perspectives of CXCR Members in the Glioma Microenvironment.DOCX by Jiarong He (11824972)

“…</p><p>Results: The mRNA expression levels of CXCR1/2/3/4/7 were significantly up-regulated in glioma than in normal samples, whereas the mRNA expression level of CXCR5 was decreased. We then summarized the genetic alteration landscape of CXCR and identified two molecular subtypes based on CXCR expression patterns in glioma. …”

Table_1_Temperature affects major fatty acid biosynthesis in noug (Guizotia abyssinica) self-compatible lines.DOCX by Adane Gebeyehu (12527500)

“…In contrast, the percentage of oleic acid in these lines grown at 21°C/18°C day/night temperatures decreased from 8.2% to 4.4% on average. There was a highly significant positive correlation between oleic acid content and temperature in SC lines.…”

Assessing hearing by measuring heartbeat: The effect of sound level by Mehrnaz Shoushtarian (6411299)

“…Following onset of the noise stimulus, heart rate initially decreased for sounds of 15 and 40 dB SPL, reaching a significantly lower rate at 15 dB SPL. …”

Variation of DNA Methylome of Zebrafish Cells under Cold Pressure by Bingshe Han (321732)

“…Our data showed that DNA methylation level of whole genome increased after a short-term cold exposure and decreased after a long-term cold exposure. …”

Light-Driven Bending Crystals of Salicylidenephenylethylamines in Enantiomeric and Racemate Forms by Hideko Koshima (1825630)

“…The reversible bending of the achiral enol-(<i>rac</i>)-<b>1</b> crystal could be repeated over 100 times, while the tip displacement angles of the chiral enol-(<i>S</i>)-<b>1</b> and enol-(<i>R</i>)-<b>1</b> crystals gradually decreased with repeated cycles. In situ X-ray measurements revealed that the bending motion of the chiral and achiral crystals was caused by a slight shrinkage of the <i>a</i> and <i>b</i> axes of the unit cell, respectively, corresponding to the long axis of the platelike crystals; shrinkage was induced by the shape change of component salicylidenephenylethylamine molecules upon photoinduced proton transfer. …”

DataSheet_2_Responses of phytoplankton communities driven by differences of source water intrusions in the El Niño and La Niña events in the Taiwan Strait during the early spring.c... by Yanping Zhong (12618612)

“…The average chlorophyll a concentration was therefore higher in 2016 than that in 2018. …”

Table 1_The CD300c antibody CL7 suppresses tumor growth by regulating the tumor microenvironment in non-small cell lung carcinoma.docx by Soyoung Kim (117362)

“…We administered CL7 intraperitoneally at doses of 5 or 10 mg/kg twice a week. Only representative data from the 10 mg/kg CL7 group are shown to maintain consistency with subsequent analyses (flow cytometry, RT-qPCR, and IHC). …”

Image_1_MiR-539-3p impairs osteogenesis by suppressing Wnt interaction with LRP-6 co-receptor and subsequent inhibition of Akap-3 signaling pathway.tif by Alok Tripathi (7054172)

“…Target prediction algorithm and experimental confirmation by luciferase 3’ UTR reporter assay identified LRP-6 as a direct target of miR-539-3p. Over expression of miR-539-3p in osteoblasts down regulated Wnt/beta catenin signaling components and deteriorated trabecular microarchitecture leading to decreased bone formation in ovariectomized (Ovx) mice. …”

Image_3_Responses of phytoplankton communities driven by differences of source water intrusions in the El Niño and La Niña events in the Taiwan Strait during the early spring.tif by Yanping Zhong (12618612)

“…The average chlorophyll a concentration was therefore higher in 2016 than that in 2018. …”