<i>Lefty1</i> and <i>Lefty2</i> are regulated by separate proximal enhancer regions in mouse embryonic stem cells. by Tiegh Taylor (5791382)

“…Strand specific GRO-seq data is shown, bidirectional transcription is a marker of active enhancers. The locations of previously identified enhancers active at embryonic day 8.5 are shown (ASE, LPE, NPE). …”

Image1_Expression pattern of the fused in sarcoma gene and its contextual influence on the density-specific response of the growth hormone/insulin-like growth factor 1 axis in zig-... by Lingzhan Xue (11117426)

“…The expression of fus exhibited a remarkable positive correlation with a specific growth rate. …”

Table_4_Somatotropic Axis Regulation Unravels the Differential Effects of Nutritional and Environmental Factors in Growth Performance of Marine Farmed Fishes.DOCX by Jaume Pérez-Sánchez (421069)

“…However, this ratio is nutritionally regulated, and enriched plant-based diets or diets with specific nutrient deficiencies downregulate hepatic ghr-i, decreasing the ghr-i/ghr-ii ratio. The same trend, due to a ghr-ii increase, is found in skeletal muscle, whereas impaired growth during overwintering is related to increase in the ghr-i/ghr-ii and igf-ii/igf-i ratios in liver and skeletal muscle, respectively. …”

Table 1_Multi-omics identification and validation of oxidative phosphorylation–related hub genes in schizophrenia.docx by Yu Zhou (89766)

“…Extending these findings in vivo, MK-801–treated mice exhibited behavioral and neuronal deficits, reduced ATP5A fluorescence intensity, and decreased ATP concentrations; expression of all four hub genes was significantly altered, with three (MALAT1, PPIL3, and ITM2A) concordant with transcriptomic results. …”

Supplementary Material for: High Indoor Microbial Levels Are Associated with Reduced Th1 Cytokine Secretion Capacity in Infancy by Lappalainen M.H.J. (4131067)

“…Five single microbial species or groups were determined using a quantitative polymerase chain reaction method. …”

Table 4_Integrated analysis of single-cell and bulk transcriptomics reveals the prognostic value and underlying mechanisms of crotonylation in ovarian cancer.xlsx by Xiaofeng Li (342614)

“…Background<p>Ovarian cancer remains the deadliest gynecological malignancy with 5-year survival rates below 40% due to frequent recurrence and chemoresistance. …”

DataSheet1_High-resolution acoustic mapping of tunable gelatin-based phantoms for ultrasound tissue characterization.docx by Heba M. Badawe (18007102)

“…The size of the focal areas increased systematically as a function of increasing applied voltage and duty cycle yet decreased as a function of increased ultrasonic frequency. …”

Down-regulated TMED10 in Alzheimer disease induces autophagy via ATG4B activation by Ji Hyun Shin (659064)

“…To explore the molecular mechanisms of autophagy, we performed a cell-based functional screening with SH-SY5Y cells stably expressing GFP-LC3, using an siRNA library and identified TMED10 (transmembrane p24 trafficking protein 10), previously known as the γ-secretase-modulating protein, as a novel regulator of autophagy. …”

Dynamics of sub-RPE CNV to sub-retinal CNV progression (P13 Progression). by Abbas Shirinifard (53980)

“…<p>A) Total number of <b>stalk cells</b> vs. <b>time</b>. …”

Helical Conformational Dynamics and Photoisomerism of Alternating Pyridinedicarboxamide/<i>m</i>-(Phenylazo)azobenzene Oligomers by Chenyang Tie (2652985)

“…¹H NMR line shape analysis of the CBz methylene hydrogens at the chain ends revealed a dynamic equilibria interconverting <i>M</i> and <i>P</i> helical conformations with energetic barriers (Δ<i>G</i>^⧧) of 11.1 (Δ<i>S</i>^⧧ = −19.4 ± 1.6 cal mol^-1 K^-1; Δ<i>H</i>^⧧ = 6.5 ± 0.4 kcal/mol) for <b>8</b> and 13.8 kcal/mol (Δ<i>S</i>^⧧ = −6.6 ± 6.2 cal mol^-1 K^-1; Δ<i>H</i>^⧧ = 11.8 ± 1.8 kcal/mol) for <b>9</b>. …”

Table_1_An etude for post-pandemic practice: The impact of the COVID-19 pandemic on practice methods and instrumental technique.XLSX by Ellen Fallowfield (14287268)

“…Participants were statistically more likely to report “never” watching online tutorials than “often” (p = 0.014), but, of those that did watch such material, 75% agreed that it had a positive impact upon their practice. Most participants created digital content during this period; only 5% produced no such material. …”

Image 4_Integrated analysis of single-cell and bulk transcriptomics reveals the prognostic value and underlying mechanisms of crotonylation in ovarian cancer.tif by Xiaofeng Li (342614)

“…Background<p>Ovarian cancer remains the deadliest gynecological malignancy with 5-year survival rates below 40% due to frequent recurrence and chemoresistance. …”

microRNA 126 Inhibits the Transition of Endothelial Progenitor Cells to Mesenchymal Cells via the PIK3R2-PI3K/Akt Signalling Pathway by Junfeng Zhang (13013)

“…In the cellular process of EndMT, there was an increase in the protein expression of PIK3R2 and the nuclear transcription factors FoxO3 and Smad4; PI3K and phosphor-Akt expression decreased, a change that was reversed markedly by overexpression of miR-126. …”

Web-based interventions for traumatized people in mainland China by Jian-Ping Wang (8434)

“…In the rural sample, the group×time interaction was also significant in PDS scores (F1,91=5.35, <i>p</i>=0.02). Posttraumatic symptoms decreased significantly after intervention (F1,48=43.97, Cohen's <i>d</i>=1.34, <i>p</i><0.001) and during the follow-up period (F1,48=24.22, Cohen's <i>d</i>=0.99, <i>p</i><0.001).…”

image_2_Impaired Differentiation of Langerhans Cells in the Murine Oral Epithelium Adjacent to Titanium Dental Implants.jpeg by Oded Heyman (5139533)

“…Further analysis revealed that while the expression of the TGF-β1 canonical receptor activing-like kinase (ALK)5 was upregulated, expression of its non-canonical receptor ALK3 was decreased. …”

Table 6_Integrated analysis of single-cell and bulk transcriptomics reveals the prognostic value and underlying mechanisms of crotonylation in ovarian cancer.csv by Xiaofeng Li (342614)

“…Background<p>Ovarian cancer remains the deadliest gynecological malignancy with 5-year survival rates below 40% due to frequent recurrence and chemoresistance. …”

Antagonistic Regulation of Parvalbumin Expression and Mitochondrial Calcium Handling Capacity in Renal Epithelial Cells by Thomas Henzi (822552)

“…Using Gene Chip Arrays and qRT-PCR, we identified differentially expressed genes in the DCT of PV-/- mice. With a focus on genes implicated in mitochondrial Ca²⁺ transport and membrane potential, uncoupling protein 2 (<i>Ucp2</i>), mitocalcin (<i>Efhd1</i>), mitochondrial calcium uptake 1 (<i>Micu1</i>), mitochondrial calcium uniporter (<i>Mcu</i>), mitochondrial calcium uniporter regulator 1 (<i>Mcur1</i>), cytochrome c oxidase subunit 1 (<i>COX1</i>), and ATP synthase subunit β (<i>Atp5b</i>) were found to be up-upregulated. …”

Flexible Microfluidic Devices for Tunable Formation of Double Emulsion by Uditha Roshan (20841937)

Image_4_Initial WNT/β-Catenin Activation Enhanced Mesoderm Commitment, Extracellular Matrix Expression, Cell Aggregation and Cartilage Tissue Yield From Induced Pluripotent Stem Ce... by Ursula Kreuser (9581357)

“…Importantly, the initial CHIR pulse increased cell proliferation until day 14 (five-fold), adjusted expression of adhesion-related genes (CDH3 up, CDH6 down) and increased extracellular matrix (ECM)-related gene expression (COL6, COL1, COL3, COL5, DCN, NPNT, LUM, MGP, MATN2, and VTN), thus yielding more matrix-interacting progenitors with a high aggregation capability. …”

Flexible Microfluidic Devices for Tunable Formation of Double Emulsion by Uditha Roshan (20841937)