Image_3_Iron Regulation in Clostridioides difficile.JPEG by Mareike Berges (5648108)

“…Proline reductase (prd), the corresponding ion pumping RNF complex (rnf) and the reaction product 5-aminovalerate were significantly enhanced. An ATP forming ATPase (atpCDGAHFEB) of the F₀F₁-type was induced while the formation of a ATP-consuming, proton-pumping V-type ATPase (atpDBAFCEKI) was decreased. …”

DataSheet1_Characterization of sclerostin’s response within white adipose tissue to an obesogenic diet at rest and in response to acute exercise in male mice.PDF by Nigel Kurgan (6533759)

“…</p><p>Methods: Male C57BL/6 mice (n = 40, 18 weeks of age) underwent 10 weeks of either a low-fat diet (LFD) or HFD. Within each diet group, mice were assigned to either remain sedentary (SED) or perform 2 h of endurance treadmill exercise at 15 m min⁻¹ with 5° incline (EX), creating four groups: LFD + SED (N = 10), LFD + EX (N = 10), HFD + SED (N = 10), and HFD + EX (N = 10). …”

Image_4_Iron Regulation in Clostridioides difficile.TIF by Mareike Berges (5648108)

“…Proline reductase (prd), the corresponding ion pumping RNF complex (rnf) and the reaction product 5-aminovalerate were significantly enhanced. An ATP forming ATPase (atpCDGAHFEB) of the F₀F₁-type was induced while the formation of a ATP-consuming, proton-pumping V-type ATPase (atpDBAFCEKI) was decreased. …”

Conceptual framework. by Karl Andraczek (16469731)

“…Pathways are sequentially numbered referring to supporting evidence, 1: [<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0287039#pone.0287039.ref046" target="_blank">46</a>, <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0287039#pone.0287039.ref047" target="_blank">47</a>], 2: [<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0287039#pone.0287039.ref010" target="_blank">10</a>, <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0287039#pone.0287039.ref044" target="_blank">44</a>], 3 and 4: [<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0287039#pone.0287039.ref016" target="_blank">16</a>], 5: [<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0287039#pone.0287039.ref011" target="_blank">11</a>, <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0287039#pone.0287039.ref015" target="_blank">15</a>], 6: [<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0287039#pone.0287039.ref047" target="_blank">47</a>], 7: [<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0287039#pone.0287039.ref013" target="_blank">13</a>, <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0287039#pone.0287039.ref014" target="_blank">14</a>, <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0287039#pone.0287039.ref048" target="_blank">48</a>], 8: [<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0287039#pone.0287039.ref028" target="_blank">28</a>, <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0287039#pone.0287039.ref033" target="_blank">33</a>]. …”

The Effect of Hyperoxia on Central and Peripheral Factors of Arm Flexor Muscles Fatigue Following Maximal Ergometer Rowing in Men by Volianitis, Stefanos

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Schematic presentation of proteins and metabolites in the <i>IPMDH</i> mutants. by Yan He (116705)

“…<p>Proteins and metabolites in red indicate increased and in green decreased in the mutants compared to wild-type. AH, aconitate hydratase; ALPase, aleurain-like protease; APase, aminopeptidase; APX, ascorbate peroxidase; ArgJ, arginine biosynthesis protein ArgJ; AsA, ascorbate acid; ASDH, aspartate semialdehyde dehydrogenase; ATCase, aspartate transcarbamylase; BCAT, branched-chain aminotransferase; CAT, catalase; CHSP70, chloroplast heat shock protein 70; CRNP, chloroplast 29 kDa ribonucleoprotein; CRR, chlororespiratory reduction; CS, citrate synthase; CYP, luminal cyclophilin; DBP, DNA-binding protein; DHA, dehydroascorbate; DHAD, dihydroxyacid dehydratase; DHAR, dehydroascorbate reductase; FBA, fructose-bisphosphate aldolase; GABA, γ-aminobutyrate; GCSH, glycine cleavage system H protein; GGAT, glutamate:glyoxylate aminotransferase; GOX, glyoxalase; GRX, glutaredoxin; GS, glutamate synthase; GSH, glutathione; GSSG, oxidized glutathione; GST, glutathione S transferase; HSC, heat shock cognate; HSK, homoserine kinase; IDH, isocitrate dehydrogenase; IPMDH, 3-isopropylmalate dehydrogenase; KARI, ketol-acid reductoisomerase; LeuC, isopropylmalate isomerase large subunit; LeuD, isopropylmalate isomerase small subunit; MAM, methylthioalkylmalate synthase; MDH, malate dehydrogenase; MDHA, monohydroascorbate; MUR, GDP-D-mannose-4,6-dehydratase; MS, methionine synthase; OAS-TL, O-acetylserine (thiol) lyase; PGM, phosphoglucomutase; PHS, alpha-glucan phosphorylase; PIFI, post-illumination chlorophyll fluorescence increase; Prx, 2-cys peroxiredoxin; PSI, photosystem I; PSII, photosystem II; RBP, RNA binding protein; SOD, superoxide dismutase; ST5B, desulfoglucosinolate sulfotransferase; SUR, superroot; TCA, tricarboxylic acid; TF, transcription factor; TIL, temperature-induced lipocalin; TLP, thylakoid lumenal protein; Trx, thioredoxin; TSP, thylakoid soluble phosphoprotein.…”

Molecular Dynamics Simulations of Threadlike Cetyltrimethylammonium Chloride Micelles: Effects of Sodium Chloride and Sodium Salicylate Salts by Zuowei Wang (333190)

“…Long threadlike micelles are found to be unstable and break into spherical micelles at low concentrations of NaCl, but remain stable for 20 ns above a threshold value of [NaCl] ≈ 3.0 M, which is about 2.5 times larger than the experimental salt concentration at which the transition between spherical and rodlike micelles occurs. …”

Tβ4 mRNA and protein expression during odontoblastic differentiation of HDPCs. by Sang-Im Lee (403297)

“…Transfection with Tβ4 siRNA decreases OM-induced odontoblastic differentiation but not affected cell growth. …”

Highly Oriented CNTs Endowing PP Foam with High Electrical Conductivity and Excellent Electromagnetic Interference Shielding by Chenguang Yang (748250)

Cell morphology varies among genetically distinct subgroups. by Laura K. Jackson (9922803)

“…<p>(<b>A</b>) Cell shape phenotype clustering on maximum likelihood tree. …”

GPC3 enhances the IGF-II-triggered IGF-1R phosphorylation by Wei Cheng (52808)

“…Either wild-type GPC3 (WT-GPC3), RR → AA or P25-29A was expressed in HEK293 cells. Transiently transfected cells were serum starved and then treated with IGF-II (20 ng/ml) for 5, 15, 30 or 60 min at 37°C, followed by western blot probed with anti-phospho-IGF-1Rβ and reprobed with anti-IGF-1R. …”

Image_2_Assessing the activity of mud volcanism using boron isotope ratios in pore water from surface sediments of mud volcanoes off Tanegashima (SW Japan).tif by Yuki Mitsutome (16702158)

“…The estimated equilibrium temperature with clay minerals using Na and Li concentrations were 93-134°C, corresponding to the temperature of environments around 3.7 to 5.3 km below the seafloor. This indicates that these components originated from these depths and that the origin depth did not reach the plate boundary in this area. …”

Extreme Evolutionary Disparities Seen in Positive Selection across Seven Complex Diseases by Erik Corona (171556)

“…There is more selection in alleles increasing, rather than decreasing, susceptibility to T1D. In the 80 SNPs most associated with T1D (p-value <7.01×10⁻⁵) showing strong signs of positive selection, 58 alleles associated with disease susceptibility show signs of positive selection, while only 22 associated with disease protection show signs of positive selection. …”

Data_Sheet_1_Deletion of the Wilms’ Tumor Suppressor Gene in the Cardiac Troponin-T Lineage Reveals Novel Functions of WT1 in Heart Development.docx by Sandra Díaz del Moral (11170191)

“…Adult mutant mice showed electrocardiographic anomalies, including increased RR and QRS intervals, and decreased PR intervals. RNASeq analysis identified differential expression of 137 genes in the E13.5 mutant heart as compared to controls. …”

Aluminum stress tolerance in potato genotypes grown with silicon by Athos Odin Severo Dorneles (6304865)

“…Plants of the Al-sensitive genotype (SMIJ319-7) and Al-tolerant genotype (SMIF212-3) were grown for two weeks in a hydroponic system with the nutrient solution containing combinations of Al (0 and 1.85 mM) and Si (0, 0.5 and 1.0 mM). …”

Gain and loss of Miple expression affect lifespan in <i>Drosophila</i>. by Fredrik Hugosson (252549)

“…<p>(<b>A</b>) Loss of Miple proteins affect lifespan. …”

Integrated view of genome-wide gene expression and DNA and histone methylation patterns. by Reo Maruyama (52782)

“…<p>(A) Genomic regions (+/− 5 kb and +/− 0 kb from DMR for K27 and K4, respectively) associated with DMRs in one cell type (e.g., CD44+ cells) are enriched for K4 or K27 mark in the other (e.g., CD24+ cells). …”

Data_Sheet_1_Risperidone Mitigates Enhanced Excitatory Neuronal Function and Repetitive Behavior Caused by an ASD-Associated Mutation of SIK1.PDF by Moataz Badawi (11080101)

“…These results indicate that risperidone has a role in decreasing neuronal excitability and excitatory synapses, ameliorating repetitive behavior in the SIK1-truncated mice.…”

ATP release differs in normal versus dystrophic muscle fibers. by Denisse Valladares (489234)

“…(C) Quantification of maximum ATP release (first peak) induced by ES in the presence of different Pannexin inhibitors. 100 µM oleamide (Olea), 5 µM carbenoxolone (Cbx) and 100 µM ¹⁰Pnx1 prevented ES-induced ATP release in normal fibers and decreased basal levels of ATP release in dystrophic fibers. …”

Pharmacological signatures of the reduced incidence and the progression of cognitive decline in ageing populations suggest the protective role of beneficial polypharmacy by Anatoly L. Mayburd (7827782)

“…Confounder analysis confirmed an independent effect of protective complexity in multivariate context. A sub-cohort with lifelong odds of dementia decreased > 5-folds was identified; this sub-cohort should be studied in further details, including controlled clinical trials. …”