Image_1_Empagliflozin Inhibits Hepatic Gluconeogenesis and Increases Glycogen Synthesis by AMPK/CREB/GSK3β Signalling Pathway.TIF by Xiaochen Yu (3796927)

“…<p>Increases in glucose production and decreases in hepatic glycogen storage induce glucose metabolic abnormalities in type 2 diabetes (T2DM). …”

Modified Taohong Siwu decoction improves cardiac function after myocardial ischaemia and reperfusion in rats by promoting endogenous stem cell mobilization and regulating metabolit... by Wan-ting Meng (13768659)

“…</p> <p>The high-dose modified THSWD group presented a reduced infarction area (decreased by 21.3%), decreased levels of lactate dehydrogenase and creatinine kinase, attenuated cell apoptosis, and enhanced superoxide dismutase activity in early stage I/R compared with other groups. …”

Image_1_The relationship of cervicothoracic mobility restrictions to fall risk and fear of falling in ankylosing spondylitis.tif by Janine L. Johnston (16450890)

“…Survival curves showed increased fall risk as cervical rotational amplitudes decreased.</p>Conclusion<p>In AS, decreased cervical rotations increase fall risk and fear of falling. …”

Drug-Tolerant Cancer Cells Show Reduced Tumor-Initiating Capacity: Depletion of CD44⁺ Cells and Evidence for Epigenetic Mechanisms by Hong Yan (27984)

“…Interestingly, drug-tolerant Du145 cells showed both increases and decreases in many “stemness” genes. Finally, evidence was provided that chronic drug exposure generated DTCs via epigenetic mechanisms involving molecules such as CD44 and KDM5A. …”

Image 2_The anti-depressive role of the Pei Yuan Kai Yu formula in cerebral small vessel disease based on gut microbiota.tif by Lixuan Yang (7331786)

“…Additionally, PY reversed inflammation-induced nerve damage; reduced the overexpression of microglia in the hippocampus; decreased the levels of hippocampal VEGF and MMP-9, and increased the levels of hippocampal occludin, ZO-1, and claudin-5. …”

Table3_Effects of Acute Exposure to Polystyrene Nanoplastics on the Channel Catfish Larvae: Insights From Energy Metabolism and Transcriptomic Analysis.XLSX by Qichen Jiang (381183)

“…<p>Microplastics (nanoplastics) pollution has been a major ecological issue threatening global aquatic ecosystems. …”

The effect of GIRK4 and RGS6 ablation on APD₈₀. by Kanchan Kulkarni (5029712)

“…<p>(A) Change in average APD₈₀ with decreasing BCL in WT, <i>Girk4</i>^<i>-/-</i>, and <i>Rgs6</i>^<i>-/-</i> hearts. (‘#’ denotes statistical significance of p < 0.05 between WT and <i>Girk4</i>^<i>-/-</i>. ‘$’ denotes statistical significance of p < 0.05 between WT and <i>Rgs6</i>^<i>-/-</i>). …”

Image7_Elabela Attenuates the TGF-β1-Induced Epithelial-Mesenchymal Transition of Peritoneal Mesothelial Cells in Patients Receiving Peritoneal Dialysis.TIF by Shunyun Xie (12898211)

“…Compared with those in patients with stage 5 chronic kidney disease who are not on dialysis, serum ELA levels in patients on PD increased with the improvement of residual renal function at PD duration <36 months and decreased to pre-dialysis levels at PD duration ≥36 months, suggesting that dialysis duration is the main risk factor affecting serum ELA levels in patients on PD. …”

Image3_Elabela Attenuates the TGF-β1-Induced Epithelial-Mesenchymal Transition of Peritoneal Mesothelial Cells in Patients Receiving Peritoneal Dialysis.tif by Shunyun Xie (12898211)

“…Compared with those in patients with stage 5 chronic kidney disease who are not on dialysis, serum ELA levels in patients on PD increased with the improvement of residual renal function at PD duration <36 months and decreased to pre-dialysis levels at PD duration ≥36 months, suggesting that dialysis duration is the main risk factor affecting serum ELA levels in patients on PD. …”

Dynamic Changes in Amino Acid Concentration Profiles in Patients with Sepsis by Longxiang Su (276106)

“…</p><p>Methods</p><p>Thirty-five critically ill patients with sepsis were included. …”

Image_2_Knockdown of LMTK3 in the Endometrioid Adenocarcinoma Cell Line Ishikawa: Inhibition of Growth and Estrogen Receptor α.tif by Guiyang Cai (11584636)

“…There was a positive correlation between the mRNA expression levels of LMTK3 and ESR1 (Spearman: P=2.011e-5, R=0.13; Pearson: P=7.18e-8, R=0.17). …”

Data Sheet 1_Constraint-based modeling of bioenergetic differences between synaptic and non-synaptic components of dopaminergic neurons in Parkinson’s disease.zip by Xi Luo (361139)

“…The synaptic PD model predicted a lower mitochondrial energy contribution and higher sensitivity to Complex I inhibition compared to the non-synaptic PD model. …”

Image_1_Effect of 15 days −6° head-down bed rest on microbial communities of supragingival plaque in young men.TIF by Di Zhu (1450108)

“…</p>Methods<p>Sixteen healthy male volunteers were recruited, and supragingival plaque samples were collected under −6° head-down bed rest (HDBR) at five-time points: day 1 before HDBR; days 5, 10, and 15 of HDBR; and day 6 of recovery. …”

Table1_Quantitative Reconstruction of Precipitation and Lake Areas During Early to Middle Holocene in Mu Us Desert, North China.docx by Dawei Li (5704)

“…Data also showed that the spatio-temporal pattern of the climate during the early to middle Holocene was relatively humid with a decreased precipitation gradient for millennia.…”

Image4_Elabela Attenuates the TGF-β1-Induced Epithelial-Mesenchymal Transition of Peritoneal Mesothelial Cells in Patients Receiving Peritoneal Dialysis.tif by Shunyun Xie (12898211)

“…Compared with those in patients with stage 5 chronic kidney disease who are not on dialysis, serum ELA levels in patients on PD increased with the improvement of residual renal function at PD duration <36 months and decreased to pre-dialysis levels at PD duration ≥36 months, suggesting that dialysis duration is the main risk factor affecting serum ELA levels in patients on PD. …”

Image 1_The anti-depressive role of the Pei Yuan Kai Yu formula in cerebral small vessel disease based on gut microbiota.tif by Lixuan Yang (7331786)

“…Additionally, PY reversed inflammation-induced nerve damage; reduced the overexpression of microglia in the hippocampus; decreased the levels of hippocampal VEGF and MMP-9, and increased the levels of hippocampal occludin, ZO-1, and claudin-5. …”

Image_1_Knockdown of LMTK3 in the Endometrioid Adenocarcinoma Cell Line Ishikawa: Inhibition of Growth and Estrogen Receptor α.tif by Guiyang Cai (11584636)

“…There was a positive correlation between the mRNA expression levels of LMTK3 and ESR1 (Spearman: P=2.011e-5, R=0.13; Pearson: P=7.18e-8, R=0.17). …”

Data_Sheet_1_Diet Type Impacts Production Performance of Fattening Lambs by Manipulating the Ruminal Microbiota and Metabolome.docx by Siqi Li (2283472)

“…This study aimed to investigate correlations among growth performance, ruminal microbiota, and ruminal metabolome of lambs fed PTMR diet. A total of 100 crossbred (Dorper sheep × Fine-wool sheep) ram lambs at 55 days of age with similar body weight (BW) (13.2 ± 0.5 kg) were randomly allocated to 10 pens that were fed either PTMR (PTMR group) or unpelleted total mixed ration (UPTMR group) with the same dietary ingredients and nutritional contents. …”

mTORC1 promotes proliferation of preosteoblasts but prevents their maturation. by Bin Huang (331329)

“…All data are mean ± SD (n = 5 mice), scale bars represent 50 μm for (A), (C), (E), (G) and 100 μm for (I). …”

Astrocytes induce proliferation of oligodendrocyte progenitor cells via connexin 47-mediated activation of the ERK/Id4 pathway by Zhaoyu Liu (3823318)

“…Astrocytes (ASTs) have been verified to play a major role in regulating the proliferation of OPCs through direct contact. …”