Extreme Evolutionary Disparities Seen in Positive Selection across Seven Complex Diseases by Erik Corona (171556)

“…There is more selection in alleles increasing, rather than decreasing, susceptibility to T1D. In the 80 SNPs most associated with T1D (p-value <7.01×10⁻⁵) showing strong signs of positive selection, 58 alleles associated with disease susceptibility show signs of positive selection, while only 22 associated with disease protection show signs of positive selection. …”

Data_Sheet_1_Deletion of the Wilms’ Tumor Suppressor Gene in the Cardiac Troponin-T Lineage Reveals Novel Functions of WT1 in Heart Development.docx by Sandra Díaz del Moral (11170191)

“…Adult mutant mice showed electrocardiographic anomalies, including increased RR and QRS intervals, and decreased PR intervals. RNASeq analysis identified differential expression of 137 genes in the E13.5 mutant heart as compared to controls. …”

Aluminum stress tolerance in potato genotypes grown with silicon by Athos Odin Severo Dorneles (6304865)

“…Plants of the Al-sensitive genotype (SMIJ319-7) and Al-tolerant genotype (SMIF212-3) were grown for two weeks in a hydroponic system with the nutrient solution containing combinations of Al (0 and 1.85 mM) and Si (0, 0.5 and 1.0 mM). …”

Integrated view of genome-wide gene expression and DNA and histone methylation patterns. by Reo Maruyama (52782)

“…<p>(A) Genomic regions (+/− 5 kb and +/− 0 kb from DMR for K27 and K4, respectively) associated with DMRs in one cell type (e.g., CD44+ cells) are enriched for K4 or K27 mark in the other (e.g., CD24+ cells). …”

Data_Sheet_1_Risperidone Mitigates Enhanced Excitatory Neuronal Function and Repetitive Behavior Caused by an ASD-Associated Mutation of SIK1.PDF by Moataz Badawi (11080101)

“…These results indicate that risperidone has a role in decreasing neuronal excitability and excitatory synapses, ameliorating repetitive behavior in the SIK1-truncated mice.…”

Pharmacological signatures of the reduced incidence and the progression of cognitive decline in ageing populations suggest the protective role of beneficial polypharmacy by Anatoly L. Mayburd (7827782)

“…Confounder analysis confirmed an independent effect of protective complexity in multivariate context. A sub-cohort with lifelong odds of dementia decreased > 5-folds was identified; this sub-cohort should be studied in further details, including controlled clinical trials. …”

Highly Oriented CNTs Endowing PP Foam with High Electrical Conductivity and Excellent Electromagnetic Interference Shielding by Chenguang Yang (748250)

Interferon-β Produces Synergistic Combinatory Anti-Tumor Effects with Cisplatin or Pemetrexed on Mesothelioma Cells by Quanhai Li (447089)

“…In this study, we examined growth inhibitory activities of type I and III IFNs on 5 kinds of human mesothelioma cells bearing wild-type <i>p53</i> gene, and showed that type I IFNs but not type III IFNs decreased the cell viabilities. …”

Image_4_Risperidone Mitigates Enhanced Excitatory Neuronal Function and Repetitive Behavior Caused by an ASD-Associated Mutation of SIK1.TIFF by Moataz Badawi (11080101)

“…These results indicate that risperidone has a role in decreasing neuronal excitability and excitatory synapses, ameliorating repetitive behavior in the SIK1-truncated mice.…”

NLRP3 expression was involved in the accumulation of NPC-LMP1-mediated MDSCs. by Ting-Ting Cai (1749844)

“…<p>(<b>A</b>) Representative immunoblots of CNE2-LMP1 and TW03-LMP1 cells treated with siNC or siNLRP3 and stained with the indicated antibodies (n = 3). …”

Sustaining rainforest remnants in plantation landscapes: degree of oil palm stand-induced edge effects on forest microclimate and regeneration by Genta Permana (14273873)

“…Significant differences were mostly observed only for variables at the forest fringe, and the reduction in edge influence was most prominent only with a minimum stand height of 8.5 m. Invasive undergrowth species penetrated less into the forest interior with more shade. …”

EFFECT OF CHRONIC INGESTION OF WINE ON THE GLYCEMIC, LIPID AND BODY WEIGHT HOMEOSTASIS IN MICE by Sebastião Barreto de BRITO-FILHO (10390814)

“…The concentration of cholesterol was lower in the WG (23.6%), as well as EG (24.5%, p<0.05). The concentration of glycogen was higher in WG (16%) and fasting blood glucose was higher in EG compared to the other groups but not both demonstrated a statistically significant difference. …”

Equatorenes: Synthesis and Properties of Chiral Naphthalene, Phenanthrene, Chrysene, and Pyrene Possessing Bis(1-adamantyl) Groups at the Peri-position by Koji Yamamoto (505190)

“…Chiral polycyclic aromatic hydrocarbons containing bis­(1-adamantyl) groups at the peri-positions, named equatorenes, were synthesized in optically pure form starting from optically pure 4,5-bis­(1-adamantyl)-8-methoxy-1-naphthol. A sequential Diels–Alder reaction of furan and arynes generated from 1,2-bromotriflates provided tricyclic and tetracyclic epoxides, and acid-catalyzed aromatization gave phenanthrol and chrysenol. …”

Image_4_Assessing the activity of mud volcanism using boron isotope ratios in pore water from surface sediments of mud volcanoes off Tanegashima (SW Japan).tif by Yuki Mitsutome (16702158)

“…The estimated equilibrium temperature with clay minerals using Na and Li concentrations were 93-134°C, corresponding to the temperature of environments around 3.7 to 5.3 km below the seafloor. This indicates that these components originated from these depths and that the origin depth did not reach the plate boundary in this area. …”

Air-Adapted <i>Methanosarcina acetivorans</i> Shows High Methane Production and Develops Resistance against Oxygen Stress by Ricardo Jasso-Chávez (120236)

“…<div><p><i>Methanosarcina acetivorans</i>, considered a strict anaerobic archaeon, was cultured in the presence of 0.4–1% O₂ (atmospheric) for at least 6 months to generate air-adapted cells; further, the biochemical mechanisms developed to deal with O₂ were characterized. …”

DataSheet_1_Global thyroid cancer incidence trend and age-period-cohort model analysis based on Global Burden of Disease Study from 1990 to 2019.csv by Le Xu (102322)

“…In 2019, The global age-standardized incidence rate (ASIR) of TC in the 5 SDI countries all showed a significant upward trend, with the largest upward trend in the middle SDI countries.…”

Data_Sheet_2_Risperidone Mitigates Enhanced Excitatory Neuronal Function and Repetitive Behavior Caused by an ASD-Associated Mutation of SIK1.PDF by Moataz Badawi (11080101)

“…These results indicate that risperidone has a role in decreasing neuronal excitability and excitatory synapses, ameliorating repetitive behavior in the SIK1-truncated mice.…”

Image_3_Risperidone Mitigates Enhanced Excitatory Neuronal Function and Repetitive Behavior Caused by an ASD-Associated Mutation of SIK1.TIFF by Moataz Badawi (11080101)

“…These results indicate that risperidone has a role in decreasing neuronal excitability and excitatory synapses, ameliorating repetitive behavior in the SIK1-truncated mice.…”

The length of lutein treatment in rMC-1 cells upon CoCl₂-induced hypoxia. by Frederic K. C. Fung (164563)

“…Lutein improved rMC-1 cell survival by decreasing Bax/Bcl-2 ratio at 24 hours. n = 5 in each group. …”

Image_1_Xiaochaihutang Inhibits the Activation of Hepatic Stellate Cell Line T6 Through the Nrf2 Pathway.TIF by Rui Hu (505795)

“…Rats in treatment groups were given the appropriate doses of XCHT granules (5 g/kg) and Silybin (50 mg/kg) for 6 days, and the serum were obtained. …”