DataSheet_1_A comprehensive investigation discovered the novel methyltransferase METTL24 as one presumably prognostic gene for kidney renal clear cell carcinoma potentially modulat... by Zhongji Jiang (13956846)

“…</p>Results<p>METTL24 expression in KIRC tissues was significantly decreased compared to normal adjacent kidney tissues, which was associated with the lower survival rate of KIRC patients. …”

Table_1_Trends in sperm quality by computer-assisted sperm analysis of 49,189 men during 2015–2021 in a fertility center from China.docx by Yanquan Li (16557348)

“…Semen volume (β1= −0.162; CI: −0.172, −0.152), sperm count (β1= −9.97; CI: −10.813, −9.128), sperm concentration (β1 = −0.535; CI: −0.772, −0.299), motility (β1 = −1.751; CI: −1.830, −1.672), and progressive motility (β1 = −1.12; CI: −0.201, −0.145) decreased with year, whereas curvilinear line velocity (VCL) (β1 = 3.058; CI: 2.912, 3.203), straight line velocity (VSL) (β1 = 2.075; CI: 1.990, 2.161), and average path velocity (VAP) (β1 = 2.305; CI: 2.224, 2.386) increased over time (all p < 0.001). …”

Image_1_Trichinella spiralis Thioredoxin Peroxidase 2 Regulates Protective Th2 Immune Response in Mice by Directly Inducing Alternatively Activated Macrophages.TIF by Qi-Wang Jin (5392352)

“…Immunization of BALB/c mice with rTsTPX2 could induce a Th1-suppressing mixed immune response given the increased levels of Th2 cytokines (IL-4 and IL-10) production along with the decreased levels of Th1 cytokines (IFN-γ, IL-12, and TNF-α). …”

Table_1_Resolvin D1 improves allograft osteointegration and directly enhances osteoblasts differentiation.pdf by Noy Pinto (14680048)

“…In vitro, RvD1 rescued OPG expression and decreased RANKL/OPG ratio in IL-17 pro-inflammatory conditions. …”

Image_4_Trib1 Contributes to Recovery From Ischemia/Reperfusion-Induced Acute Kidney Injury by Regulating the Polarization of Renal Macrophages.TIF by Xiangcheng Xie (8601513)

“…Furthermore, the M1/M2 macrophage ratio increased in the first 3 days and decreased from day 7 to day 28, consistent with changes in the expression of inflammatory factors, including TNFα, IL-6, IL-12, IL-10, and IL-13. …”

Data_Sheet_1_High Estimated Glomerular Filtration Rate Is Associated With Worse Cognitive Performance in the Hypertensive Population: Results From the China H-Type Hypertension Reg... by Junpei Li (11542765)

“…The MMSE increased significantly with the increment of eGFR (β, 0.27; 95% CI: 0.12–0.41) in participants with eGFR < 71.52 ml/min/1.73 m² and decreased (β, −0.28; 95% CI: −0.39 to −0.17) in participants with eGFR ≥ 71.52 ml/min/1.73 m². …”

Table4_Sex-differences in associations of LV structure and function measured by echocardiography with long-term risk of mortality and cardiovascular morbidity.docx by Lamia Al Saikhan (12643396)

“…In men increased LV volumes and LVSI and decreased LVRI and EF were associated with higher mortality, but associations were null or reversed in women (hazard ratios (95% CI) men vs. women: EDV 1.25 (1.05, 1.48) vs. 0.54 (0.26, 1.10); ESV, 1.36 (1.12, 1.63) vs. 0.59 (0.33, 1.04); LVRI, 0.79 (0.64, 0.96) vs. 1.70 (1.03, 2.80); LVSI, 1.27 (1.05, 1.54) vs. 0.61 (0.32, 1.15); and EF, 0.78 (0.66, 0.93) vs. 1.27 (0.69, 2.33). …”

Data_Sheet_1_Anaplasma phagocytophilum Activates NF-κB Signaling via Redundant Pathways.docx by J. Stephen Dumler (7274654)

“…Wedelolactone and SC-514 reversed downregulation in all 64 and 45, respectively, of the genes down-regulated by infection, but decreased expression in 1 gene with SC-514 only. Silencing of 20 NF-κB signal pathway genes increased bacterial growth in 12 (IRAK1, MAP3K1, NFKB1B, MAP3K7, TICAM2, TLR3, TRADD, TRAF3, CHUK, IRAK2, LTBR, and MALT1). …”

Penile coital injuries in men decline after circumcision: Results from a prospective study of recently circumcised and uncircumcised men in western Kenya by Nelli Westercamp (4503574)

“…<div><p>Background</p><p>Penile coital injuries are one of the suggested mechanisms behind the increased risk of HIV among uncircumcised men. We evaluated the prevalence and correlates of self-reported penile coital injuries in a longitudinal community-based cohort of young (18–24 years old), newly circumcised and uncircumcised men in Western Kenya.…”

Impact of HIV on CD8+ T Cell CD57 Expression Is Distinct from That of CMV and Aging by Sulggi A. Lee (528197)

“…</p><p>Results</p><p>Compared to HIV-uninfected adults without CMV (n = 12), those with asymptomatic CMV infection (n = 31) had a higher proportion of CD28-CD8+ T cells expressing CD57 (P = 0.005). …”

Combined B, T and NK Cell Deficiency Accelerates Atherosclerosis in BALB/c Mice by Fei Cheng (315348)

“…<div><p>This study focused on the unique properties of both the <i>Ldlr</i> knockout defect (closely mimicking the human situation) and the BALB/c (C) inbred mouse strain (Th-2 slanted immune response). We generated two immunodeficient strains with severe combined B- and T-cell immunodeficiency with or without a complete lack of natural killer cells to revisit the role of adaptive immune responses on atherogenesis. …”

Table_2_Anaplasma phagocytophilum Activates NF-κB Signaling via Redundant Pathways.XLSX by J. Stephen Dumler (7274654)

“…Wedelolactone and SC-514 reversed downregulation in all 64 and 45, respectively, of the genes down-regulated by infection, but decreased expression in 1 gene with SC-514 only. Silencing of 20 NF-κB signal pathway genes increased bacterial growth in 12 (IRAK1, MAP3K1, NFKB1B, MAP3K7, TICAM2, TLR3, TRADD, TRAF3, CHUK, IRAK2, LTBR, and MALT1). …”

Plasma Concentrations of BDNF and IGF-1 in Abstinent Cocaine Users with High Prevalence of Substance Use Disorders: Relationship to Psychiatric Comorbidity by María Pedraz (697333)

“…Interestingly, plasma BDNF concentrations were exclusively found to be decreased in users diagnosed with both primary and cocaine-induced disorders for mood and anxiety disorders. …”

Evaluation of the immunomodulatory activity of thalidomide on tumor-associated macrophages in the 4T1 murine metastatic breast cancer model by D.C. Reis (4770336)

“…<div><p>ABSTRACT The present work evaluated the immunomodulatory effect of thalidomide (Thal) at different doses on tumor-associated macrophages (TAMs) using a mouse model of human breast cancer. Mice were inoculated with 4T1 cells in the left flank and treated with Thal once a day at concentrations of 50, 100, and 150mg/kg body weight from the 5th day until the 28th day of tumor inoculation. …”

The epidemiology of dengue disease in the Philippines, 2000–2011. by Lulu Bravo (655497)

“…Overall, the CFR was in the range 0.5–1.2 per 100 cases and decreased after 2005. Using available data* from the DoH <a href="http://www.plosntds.org/article/info:doi/10.1371/journal.pntd.0003027#pntd.0003027-Department1" target="_blank">[5]</a>, <a href="http://www.plosntds.org/article/info:doi/10.1371/journal.pntd.0003027#pntd.0003027-Department3" target="_blank">[25]</a>–<a href="http://www.plosntds.org/article/info:doi/10.1371/journal.pntd.0003027#pntd.0003027-Department7" target="_blank">[29]</a> and the WHO <a href="http://www.plosntds.org/article/info:doi/10.1371/journal.pntd.0003027#pntd.0003027-World1" target="_blank">[6]</a>, <a href="http://www.plosntds.org/article/info:doi/10.1371/journal.pntd.0003027#pntd.0003027-LeeSuy1" target="_blank">[16]</a>, <a href="http://www.plosntds.org/article/info:doi/10.1371/journal.pntd.0003027#pntd.0003027-World4" target="_blank">[20]</a>, <a href="http://www.plosntds.org/article/info:doi/10.1371/journal.pntd.0003027#pntd.0003027-World5" target="_blank">[21]</a>, <a href="http://www.plosntds.org/article/info:doi/10.1371/journal.pntd.0003027#pntd.0003027-World6" target="_blank">[30]</a>–<a href="http://www.plosntds.org/article/info:doi/10.1371/journal.pntd.0003027#pntd.0003027-World8" target="_blank">[32]</a>. …”

Enhanced oil recovery using hyperbranched polyglycerol polymer-coated silica nanoparticles by Elmobarak W.F.

“…dem improved as the Csur and pH decreased, with maximum values of 98.8% and 98.5% achieved at Csur = 0.05 g/L and a pH = 4, respectively. …”
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PAD-mediated inhibition in DRG neurons. by Petri Takkala (3344276)

“…Note that rheobase increases with increases in <i>ḡ</i>_GABA, whereas spike height decreases. <b>(D)</b> Change in rheobase (mean ± SEM) is plotted against <i>ḡ</i>_GABA for <i>E</i>_GABA = -35 mV (blue, <i>n</i> = 3 cells) and -20 mV (red, <i>n</i> = 4 cells). …”

Angiogenic response in ischemic limbs. by Masayuki Kubo (298705)

“…Quantitative analysis revealed that the blood flow (B) and microvessel density (D) in the ischemic hindlimb significantly decreased in the HSF1-KO mice compared to the WT mice, 21 days after the induction of ischemia (n = 5 or 6 animals/group).…”

Co-immunoprecipitation experiments to examine the interactions of beclin-1 with Bcl-2 and Bcl-xL. by Tai-Ho Hung (306051)

“…Data are presented as mean ± SEM for 5 separate experiments. *, <i>P</i><0.05, in comparison to vehicle controls.…”

Directionality of main and interactive effects. by Nathaniel Haines (6298427)

“…Partial dependence indicates the predicted affect intensity while integrating over all other AUs. Panel (A) shows the directionality of main effects, where increasing (decreasing) values indicate positive (negative) effects as AU presence increases. …”