FIGURE 2 from Novel Spirocyclic Dimer, SpiD3, Targets Chronic Lymphocytic Leukemia Survival Pathways with Potent Preclinical Effects by Alexandria P. Eiken (18597722)

“…BET inhibitor, JQ-1 (1 µmol/L), served as a positive control for cell cycle arrest (<i>n</i> = 5 independent experiments). …”

Heat shock induces some developmentally regulated mRNAs. by Igor Minia (399074)

“…Categories are: (i) 246 mRNAs that increased in abundance after heat shock (Padj <0.01 and 39/27 >2, pale cyan ellipse); (ii) 1775 mRNAs that are >2x more abundant in salivary gland (SG) trypanosomes than in procyclic form (PC) trypanosomes (SG>2XPC, yellow); (iii) 2509 mRNAs that are >2x more abundant in salivary gland (SG) trypanosomes than in bloodstream form (BS) trypanosomes (SG>2XBS, orange); (iv) 985 mRNAs that are >2x more abundant in bloodstream form (BS) trypanosomes than in procyclic form (PC) trypanosomes [<a href="http://www.plosntds.org/article/info:doi/10.1371/journal.pntd.0004982#pntd.0004982.ref029" target="_blank">29</a>] (BS>2xPC, pink); (v) mRNAs that decreased in abundance after heat shock (Padj <0.01 and 39/27 <0.5, labelled as 27>39, violet); (vi) 582 mRNAs that are >2x less abundant in salivary gland (SG) trypanosomes than in procyclic form (PC) trypanosomes (PC>2xSG, dark green), and (vii) 872 mRNAs that are >2x less abundant in bloodstream form (BS) trypanosomes than in procyclic form (PC) trypanosomes [<a href="http://www.plosntds.org/article/info:doi/10.1371/journal.pntd.0004982#pntd.0004982.ref029" target="_blank">29</a>] (PC>2xBS, pale green). …”

Mechanical characteristics of ultra-high performance steel FRC made with recycled concrete aggregates by Alnahhal, W.

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Distribution of fitness effects of new mutations. by Boaz Shvartzman (18272357)

“…<p><b>(A)</b> The distribution of fitness effects (DFE) evolved during the <i>in-silico</i> evolutionary experiment: the frequency of lethal mutations decreased (red line) and the frequency of neutral and slightly deleterious mutations increased (blue line). …”

Magnetic tweezers setup for parallel translation of bead chains. by Kaiyuan Yang (135297)

“…Scale bar, 5 mm. (c): A 21-bead chain in the magnetic field of a single cone magnet, aligning with the field <b>B</b> (white arrow) along the <i>x</i>-axis, and translating towards the magnetic field gradient ∇<b>B</b> (black arrow). …”

The application of Compont gel in chronic obstructive jaundice rats model by Wei-wei Luo (6798557)

“…Results: Group B showed a fluctuant development of jaundice, obstructive degree reached a peak at 2 weeks, and decreased from 3 weeks. …”

Supplementation of copaiba or sucupira oils in broiler diets by Raiana Almeida Noleto (4643071)

“…Data were submitted to analysis of variance and Tukey test (5%). The addition of sucupira oil at 500 mg/kg decreased broiler performance at 21, 33, and 40 days of age, whereas the addition of copaiba oil resulted in similar performance relative to the antibiotic. …”

PHGDH upregulation by the HER2 oncogene supports insulin-independent proliferation of MCF10HER2 cells. by Aliccia Bollig-Fischer (227291)

“…The experiment was done using two PHGDH-targeted vectors and a non-silencing control vector. While mRNA levels were reduced nearly 80%, the amount of protein appears to be decreased by only one half. …”

Alternate display format of TAG/DAG-species and FA-species. by Thomas Kopf (548745)

“…In the diagrams the species shown in red have increased levels between the two respective groups, while a blue color indicates a decreased level of the respective species between the two groups. …”

Kinetic parameter differences between leukemic and healthy cells. by Daphne Ezer (3072147)

“…<p>This figure illustrates kinetic parameter change predictions for the single cell qPCR data in Guo et al. Just as in Figs <a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1005072#pcbi.1005072.g005" target="_blank">5</a> and <a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1005072#pcbi.1005072.g006" target="_blank">6</a>, red boxes indicate that <i>K</i>_<i>on</i> varies, yellow boxes indicate that <i>K</i>_<i>t</i> varies and orange boxes signify that both parameters change. …”

Respiratory Exchange Ratio (RER) in ADKD and ADOX WT and OB mice. by Kazuhisa Watanabe (426012)

“…<p>Mice were chow-fed, 10-week-old B6 (WT) or B6.V-Lep^ob/J (OB) males, at 4 to 5 days p.t. with adenovirus knockdown vectors expressing RNAi for <i>lacZ</i> or <i>Ildr2</i> or with adenovirus vectors over- expressing <i>GFP</i> or <i>Ildr2</i>. …”

Folding kinetics of CFSE using Treekin. by Vaitea Opuu (4966111)

“…<p>A) Barrier tree of the CFSE. From a set of 1.5 × 10⁶ sub-optimal structures, 40 local minima were found, connected through saddle points. …”

Aneuploidy formation and FLC resistance in the <i>C. neoformans</i> strain H99. by Kyung J. Kwon-Chung (51675)

“…<p>(A) The percentage of FLC-resistant population in H99^R64 (resistant at 64 ug/ml FLC) decreases during daily transfer in drug-free media. …”

Magnetic tweezers setup for perpendicular translation of bead chains. by Kaiyuan Yang (135297)

“…Scale bar, 5 mm. (c): As viewed in the field of view, a 24-bead chain in the magnetic field of a pair of magnets, aligning with the field <b>B</b> (white arrow) along the <i>y</i>-axis, and translating towards the magnetic field gradient ∇<b>B</b> (black arrow). …”

General Health Questionnaire (GHQ12): new evidence of construct validity by Tulio Augusto Andrade Oliveira (14728698)

“…The study included 1,085 physicians with a mean age of 45.7 (SD = 10.6), mostly male (61.5%), married (72.6%) and Catholic (59.2%). …”

The α₁-adrenoceptors in the mouse femoral arterial bed are of the α_1L-subtype. by Joseph Zacharia (420909)

“…</i> Prazosin (10.0 nM to 1.0 µM) produced successive increases in fractional diameter (i.e. decreased active vascular tone). These arteries were isolated and mounted on a wire myograph for force measurement (B) <i>Ex vivo</i> characterization of α₁-receptors in femoral artery: Prazosin (10 nM–1 µM, n = 5) produced concentration-dependent parallel rightward shifts in the potency of phenylephrine (PE) without significantly affecting the maximum responses. …”

Effect of SC-1 on Protein Expression Levels of phospho-ERK1/2, and OCT4 in Colon Tumor Lines. by Susan D. Mertins (380936)

“…<p>Colon tumor lines were treated with SC-1 (0.1 µM), harvested, lysed, and probed for the proteins of interest following electrophoresis in SDS-PAGE gels at the indicated time points. A. In the SC-1 treated HT29 tumor line, phospho-ERK1/2/total ERK1/2 protein levels were decreased to 67±0.06% of control value at 5 min, 56±0.06% of control value at 30 min, and 46±0.06% of control value at 1 hr (n = 3, p<0.05). …”

Citral inhibition of I_TRPV1 reveals the expression of TRPV2 and TRPV3 in acutely isolated dorsal root ganglion neurons. by Stephanie C. Stotz (129157)

“…<p>(A) Two patterns of response to repetitive 2-aminoethyldiphenyl borate application were noted within the dorsal root ganglion population following citral block of capsaicin-activated currents; dorsal root ganglion currents decreased in six neurons (left), and increased in the remaining neurons (right; n = 6; +100 mV). …”

Effect of testosterone treatment on ligand-dependent activation of the EGFR and downstream signaling pathways in smooth muscle vascular cells. by Marta del Campo (596854)

“…The plots (B–E) present the mean ± SEM phosphorylation of the EGFR (n = 4) (B), p115 (n = 5) (C), Akt (n = 6) (D), and ERK1/2 (n = 6) (E) from a set of experiments similar to those shown in A.…”

Sensitivity of the mitotic checkpoint response. by Fridolin Gross (384234)

“…It is reasonable to assume that the association rate for an active checkpoint lies between 5 and 500 (in units of 1/min*[total Mad]) [<a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1006449#pcbi.1006449.ref014" target="_blank">14</a>, <a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1006449#pcbi.1006449.ref042" target="_blank">42</a>]. …”