Knockout simulations reveal the major role of C4BP. by Bing Liu (70818)

“…Profiles of deposited cleaved/uncleaved C4 fragments across time points of 0–3.5 h under infection-inflammation condition occurring via classical pathway (triggered by PC beads) in untreated or treated sera with increased C4BP or decreased C4BP were studied. …”

PTEN regulates Maf1 protein expression. by Beth M. Palian (673045)

“…<p>(<b>A</b>) <u>Maf1 expression is decreased in mouse cells and tissues lacking PTEN</u>. …”

Depletion of UBQLN1 leads to genome instability. by Haoxian Zhou (8939966)

“…The micronuclei were counted. Scale bars, 5μm. All values are means ± SEM of more than three independent experiments (* P<0.05, ** P<0.01, *** P<0.001, ****P<0.0001).…”

Metabolomic analysis revealed an alteration in the intermediates of glycolysis, the TCA cycle, and amino acids. by Junji Okuda (444322)

“…While metabolites of the first half of the TCA cycle, such as acetyl-CoA and cis-aconitate, were increased, those of the latter half, such as fumarate, were decreased (n = 5 for each group). …”

Hypoxia down-regulates Wnt/β-catenin signaling in human OS cells. by Donald J. Scholten II (649432)

“…B, Axin2 mRNA levels were determined as a measure of Wnt/β-catenin signaling under hypoxic conditions (72 hour, 0.5% O₂) via quantitative reverse-transcription PCR (qrt-PCR) normalized to normoxia. …”

The expression level of Bcl-xL is increased in chemoresistant cells and its suppression reduces carboplatin resistance. by Natini Jinawath (247165)

“…B and C) Knockdown effect of Bcl-xL shRNA in SKOV3-CR cells (B) and in A2780-CR cells (C). After transfection with Bcl-xL shRNA and selection with puromycin for 5–7 days, Bcl-xL expression level decreases (left panels). …”

Sustained Effects of Developmental Exposure to Ethanol on Zebrafish Anxiety-Like Behaviour by Matteo Baiamonte (721514)

“…(A-D) Developmental ethanol exposure decreased thigmotaxis at both 9dpf (A,B: <i>F</i> 2,105 = 4.76, <i>P</i><0.05) and 10dpf (C,D: <i>F</i> 2, 285 = 6.69, <i>P</i><0.05), with the greatest difference between 20mM ethanol treatment and the control. …”

Regulation of cytoprotective gene activation is required for xenobiotic stress tolerance. by David E. Shore (123998)

“…Animals were raised to day 3 adulthood on solid media and transferred to solution containing sublethal (∼LD30) treatments of 24 mg/ml paraquat (A), 22 µg/ml sodium azide (B), 5.2 mg/ml cadmium chloride (C), 696 µg/ml antimycin (D) or solvent alone (<a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1002792#pgen.1002792.s004" target="_blank">Figure S4</a>). …”

Spatial distribution of interactions. by Evlyn Pless (822892)

“…The left figure of each pair shows interactions at the very beginning of an experiment that decreased the rate of incoming foragers, and the right figure shows interactions 3–5 minutes after the experiment was complete. …”

Mice with metastatic lung cancer develop anemia with reticulocytosis. by Airie Kim (544745)

“…Compared to controls, the tumor-bearing mice have: (A) decreased hemoglobin; (B) increased reticulocytosis. …”

Boxplots corresponding to Fig 7. by Lianna Zhao (18239240)

“…Furthermore, when mask-wearing compliance reaches 80%, the maximum infection rate significantly decreases to approximately 5%.</p>…”

MicroRNA and cellular targets profiling reveal miR-217 and miR-576-3p as proviral factors during Oropouche infection by Victor Emmanuel Viana Geddes (5309945)

“…Finally, we showed that virus escape IFN-β mediated immune response increasing the levels of cellular miR-576-3p resulting in a decreasing of its partners STING and TRAF3. We concluded stating that the present study, the first for a <i>Peribunyaviridae</i> member, gives insights in its prospective pathways that could help to understand virus biology, interactions with host cells and pathogenesis, suggesting that the virus escapes the antiviral cellular pathways increasing the expression of cognates miRNAs.…”

Data_Sheet_1_Insulin Modulates the Immune Cell Phenotype in Pulmonary Allergic Inflammation and Increases Pulmonary Resistance in Diabetic Mice.pdf by Sabrina S. Ferreira (8432574)

“…</p><p>Materials and Methods: To evaluate the effects of relative insulin deficiency, an experimental model of diabetes was induced by a single dose of alloxan (50 mg/kg, i.v.). After 10 days, the mice were sensitized with ovalbumin [OVA, 20 μg and 2 mg of Al(OH)₃, i.p.]. …”

The effect of ZAP-S on L1 RNA and L1 protein expression. by John B. Moldovan (240328)

“…<p><i>(A) Schematic of pJM101/L1</i>.<i>3Δneo</i>: Bold black lines indicate the approximate location of probes (5UTR99 and ORF2_5804) used in the northern blot experiments. pJM101/L1.3Δneo is expressed from a pCEP4 vector. …”

Surface zeta potential and diamond seeding on gallium nitride films by Soumen Mandal (19079480)

“…Films were grown at 850 °C, under 5% methane admixture (CH4/H2) conditions to a thickness of ~150 nm, as judged by in-situ laser interferometry. …”

DataSheet1_Predicting protective gene biomarker of acute coronary syndrome by the circRNA-associated competitive endogenous RNA regulatory network.docx by Hengliang Zhang (13980072)

“…The qRT-PCR analysis result showed that the XPNPEP1, UCHL1, GPC6 and RAD51 genes had a significantly decreased expression in ACS patients. …”

Heat shock induces some developmentally regulated mRNAs. by Igor Minia (399074)

“…Categories are: (i) 246 mRNAs that increased in abundance after heat shock (Padj <0.01 and 39/27 >2, pale cyan ellipse); (ii) 1775 mRNAs that are >2x more abundant in salivary gland (SG) trypanosomes than in procyclic form (PC) trypanosomes (SG>2XPC, yellow); (iii) 2509 mRNAs that are >2x more abundant in salivary gland (SG) trypanosomes than in bloodstream form (BS) trypanosomes (SG>2XBS, orange); (iv) 985 mRNAs that are >2x more abundant in bloodstream form (BS) trypanosomes than in procyclic form (PC) trypanosomes [<a href="http://www.plosntds.org/article/info:doi/10.1371/journal.pntd.0004982#pntd.0004982.ref029" target="_blank">29</a>] (BS>2xPC, pink); (v) mRNAs that decreased in abundance after heat shock (Padj <0.01 and 39/27 <0.5, labelled as 27>39, violet); (vi) 582 mRNAs that are >2x less abundant in salivary gland (SG) trypanosomes than in procyclic form (PC) trypanosomes (PC>2xSG, dark green), and (vii) 872 mRNAs that are >2x less abundant in bloodstream form (BS) trypanosomes than in procyclic form (PC) trypanosomes [<a href="http://www.plosntds.org/article/info:doi/10.1371/journal.pntd.0004982#pntd.0004982.ref029" target="_blank">29</a>] (PC>2xBS, pale green). …”

Mechanical characteristics of ultra-high performance steel FRC made with recycled concrete aggregates by Alnahhal, W.

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Distribution of fitness effects of new mutations. by Boaz Shvartzman (18272357)

“…<p><b>(A)</b> The distribution of fitness effects (DFE) evolved during the <i>in-silico</i> evolutionary experiment: the frequency of lethal mutations decreased (red line) and the frequency of neutral and slightly deleterious mutations increased (blue line). …”

Magnetic tweezers setup for parallel translation of bead chains. by Kaiyuan Yang (135297)

“…Scale bar, 5 mm. (c): A 21-bead chain in the magnetic field of a single cone magnet, aligning with the field <b>B</b> (white arrow) along the <i>x</i>-axis, and translating towards the magnetic field gradient ∇<b>B</b> (black arrow). …”