Image_2_Tocilizumab (TCZ) Decreases Angiogenesis in Rheumatoid Arthritis Through Its Regulatory Effect on miR-146a-5p and EMMPRIN/CD147.jpeg by Devy Zisman (11838428)

“…In vitro, the accumulation in the supernatants of the pro-angiogenic factors EMMPRIN, VEGF and MMP-9 was increased by co-culturing the HT1080 fibroblasts and the U937 monocytes, while the accumulation of the anti-angiogenic factor thrombospondin-1 (Tsp-1) and the expression levels of miR-146a-5p were reduced. Transfection of HT1080 cells with the miR-146a-5p mimic, decreased the accumulation of EMMPRIN, VEGF and MMP-9. …”

Image_1_Tocilizumab (TCZ) Decreases Angiogenesis in Rheumatoid Arthritis Through Its Regulatory Effect on miR-146a-5p and EMMPRIN/CD147.jpeg by Devy Zisman (11838428)

“…In vitro, the accumulation in the supernatants of the pro-angiogenic factors EMMPRIN, VEGF and MMP-9 was increased by co-culturing the HT1080 fibroblasts and the U937 monocytes, while the accumulation of the anti-angiogenic factor thrombospondin-1 (Tsp-1) and the expression levels of miR-146a-5p were reduced. Transfection of HT1080 cells with the miR-146a-5p mimic, decreased the accumulation of EMMPRIN, VEGF and MMP-9. …”

RNF5 loss decreases ERK and Akt activation, CDK1 and Smo expression and KSHV lytic replication in PEL cells. by Xiaojuan Li (351842)

Lack of PD-L1 expression by host tissues increases numbers of activated donor T cells but decreases donor Tregs in spleen. by Mohammad S. Hossain (415643)

Preserved NSS at 2 and at 24 hours following ischemia and decreased infarct volume in PAR1 KO mice 24 hours following ischemic stroke. by Efrat Shavit-Stein (3186678)

“…(C) Total infarct volume is significantly lower in PAR1 KO mice compared to control (t-test, WT = 6, PAR1 KO = 6). (D) Infarct volume decreases as a function of distance from the ischemic core (slices #5&6). …”

Promoter reporter studies for SF-1 regulating the human <i>BDNF</i> promoter I and comparative studies of specific <i>NR5A1</i> mutations on <i>BDNF</i> promoter activity. by Jana Malikova (615672)

Subjects:

Administration of γPGA attenuates Th2 immune responses elicited by the cysteine protease papain through a decrease in basophils. by Hyun Jung Park (116737)

Promoter reporter studies for reported <i>NR5A1</i> mutations by Jana Malikova (615672)

Subjects:

Increased accumulation of mutant huntingtin aggregates and decreased mobility of autophagosomes in the axon of AP-4 ε KO hippocampal neurons. by Raffaella De Pace (5147120)

Su(H) and RBPJ AOS variants decrease DNA binding. by Ellen K. Gagliani (11478756)

HIV-1 CA mutations selected during passage in rhTRIM5α-expressing cells decrease sensitivity to rhTRIM5α. by Steven J. Soll (270043)

Mfsd2a KO mice have decreased liver TG with normal liver metabolism. by Justin H. Berger (297156)

Loss of nsp14-ExoN activity decreases recombination frequency and alters recombination junction patterns across the genome. by Jennifer Gribble (10005444)

ASO treatment suppresses the palbociclib-mediated induction of MEG3 and decrease in cell proliferation in SK-MES-1 cells. by Traci L. Kruer (3342425)

TIMP3 overexpression decreases tibial bone mechanical properties from macroscale to nanoscale mechanics. by Blandine Poulet (2939877)

“…<p>A, Von Kossa staining of tibia epiphysis and metaphysis of WT and TIMP3 Tg/Tg mice showed decreased trabecular bone in TIMP3 Tg/Tg mice (Magnification x2). …”

Increased ROS level decreases RLS in respiratory-deficient cells. by Dae-Gwan Yi (5410298)

HO-1 overexpression decreases Nox4 activity in C-20/A4 chondrocytes. by Francis Rousset (424375)

Decreased GH storage and secretion in PICK1-deficient mice. by Birgitte Holst (250548)

“…<p>(A) The livers of PICK-1-deficient mice had a significantly lower weight than those of WT mice (**<i>p</i><0.01). …”

hMSC implantation decreased striatal atrophy in HD mice. by Brooke R. Snyder (253093)

Immobility time of NrbKO and SpKO mice in the forced swim test (FST) at 3–5 months of age (young adult). by Huiying Wu (1587136)