Supplementary Material for: Clinical Trial of Vadadustat in Patients with Anemia Secondary to Stage 3 or 4 Chronic Kidney Disease by Martin E.R. (3859435)

“…<b><i>Methods:</i></b> A phase 2a, multicenter, randomized, double-blind, placebo-controlled, dose-ranging trial (NCT01381094) was undertaken in adults with anemia secondary to CKD stage 3 or 4. …”

Disrupted elncRNA splicing impacts <i>cis</i>-gene regulation. by Jennifer Yihong Tan (11933872)

“…<p>(A) Examples of variants that can disrupt elncRNA splicing. …”

Table_2_Global Characterization of Peripheral B Cells in Parkinson’s Disease by Single-Cell RNA and BCR Sequencing.xlsx by Pingping Wang (1485592)

“…Finally, we found a marked clonal expanded memory B cell population in PD patients, up-regulating both MHC II genes (HLA-DRB5, HLA-DQA2 and HLA-DPB1) and transcription factor activator protein 1 (AP-1), suggesting that the antigen presentation capacity of B cells was enhanced and B cells were activated in PD patients. …”

DataSheet8_Mogrol Attenuates Osteoclast Formation and Bone Resorption by Inhibiting the TRAF6/MAPK/NF-κB Signaling Pathway In vitro and Protects Against Osteoporosis in Postmenopau... by Yongjie Chen (269938)

“…Furthermore, RT–PCR indicated that mogrol suppressed osteoclastogenesis-related gene expression, including CTSK, ACP5, MMP9 and DC-STAMP, in RANKL-induced bone marrow macrophages Western blotting demonstrated that mogrol suppressed osteoclast formation by blocking TNF receptor-associated factor 6 (TRAF6)-dependent activation of the mitogen-activated protein kinase nuclear factor-B (NF-κB) signaling pathway, which decreased two vital downstream transcription factors, the nuclear factor of activated T cells calcineurin-dependent 1 (NFATc1) and c-Fos proteins expression. …”

DataSheet9_Mogrol Attenuates Osteoclast Formation and Bone Resorption by Inhibiting the TRAF6/MAPK/NF-κB Signaling Pathway In vitro and Protects Against Osteoporosis in Postmenopau... by Yongjie Chen (269938)

“…Furthermore, RT–PCR indicated that mogrol suppressed osteoclastogenesis-related gene expression, including CTSK, ACP5, MMP9 and DC-STAMP, in RANKL-induced bone marrow macrophages Western blotting demonstrated that mogrol suppressed osteoclast formation by blocking TNF receptor-associated factor 6 (TRAF6)-dependent activation of the mitogen-activated protein kinase nuclear factor-B (NF-κB) signaling pathway, which decreased two vital downstream transcription factors, the nuclear factor of activated T cells calcineurin-dependent 1 (NFATc1) and c-Fos proteins expression. …”

Data_Sheet_1_Conjunctival infiltrates and cytokines in an experimental immune-mediated blepharoconjunctivitis rat model.docx by Aihua Hou (469259)

“…Purpose<p>To characterize the histopathological and immunological findings of a rat model of allergic blepharoconjunctivitis (BC) and demonstrate its potential utility for the assessment of BC therapies.…”

Table_11_Transcriptome in Combination Proteome Unveils the Phenylpropane Pathway Involved in Garlic (Allium sativum) Greening.XLSX by Jinxiang Wu (475283)

“…The greening phenomenon of garlic severely decreases the quality of garlic and hinders garlic processing. …”

Table_1_Let-7g* and miR-98 Reduce Stroke-Induced Production of Proinflammatory Cytokines in Mouse Brain.DOCX by David L. Bernstein (9133364)

“…<p>Stroke is a debilitating illness facing healthcare today, affecting over 800,000 people and causing over 140,000 deaths each year in the United States. …”

Image_2_Enhanced phosphatidylserine exposure and erythropoiesis in Babesia microti-infected mice.tif by Peng Song (281947)

“…The physiological indicators were analyzed using a Mindray BC-5000 Vet automatic hematology analyzer.…”

Dataset for paper: Consequences of approximating electron correlation effects by Hazel Cox (4460596)

“…<h3>Data for paper published in Molecular Physics Nov 2022</h3> <p>The zip file contains 7 subdirectories containing (i) optimised wavefunctions (ii) static Coulomb hole data (fig 3), (iii) dynamic Coulomb hole data (fig 4 & 5), (iv) ‘exact’ electron correlation energy data (fig 6) (v) energy density data as a function of the intracule coordinate r (fig 7), (vi) energy density data as a function of the extracule coordinate R (fig 8), (vii) radial electron correlation energy distribution data using CS and LYP functional (fig 9). …”

Audio_2_Retroauricular/Transcranial Color-Coded Doppler Ultrasound Approach in Junction With Ipsilateral Neck Compression on Real-Time Hydroacoustic Variation of Venous Pulsatile T... by Xiuli Gao (2036302)

“…To reveal the hydroacoustic characteristics of disparate segments of venous return, a computational fluid dynamics (CFD) technique combined with the transcranial color-coded Doppler method was performed. …”

DataSheet7_Mogrol Attenuates Osteoclast Formation and Bone Resorption by Inhibiting the TRAF6/MAPK/NF-κB Signaling Pathway In vitro and Protects Against Osteoporosis in Postmenopau... by Yongjie Chen (269938)

“…Furthermore, RT–PCR indicated that mogrol suppressed osteoclastogenesis-related gene expression, including CTSK, ACP5, MMP9 and DC-STAMP, in RANKL-induced bone marrow macrophages Western blotting demonstrated that mogrol suppressed osteoclast formation by blocking TNF receptor-associated factor 6 (TRAF6)-dependent activation of the mitogen-activated protein kinase nuclear factor-B (NF-κB) signaling pathway, which decreased two vital downstream transcription factors, the nuclear factor of activated T cells calcineurin-dependent 1 (NFATc1) and c-Fos proteins expression. …”

Data Sheet 1_Trends in sepsis-associated cardiovascular disease mortality in the United States, 1999 to 2022.pdf by Malik Salman (20401364)

“…Sepsis-associated CVD mortality decreased between 1999 and 2013, from AAMR of 65.7 in 1999 to 58.8 in 2013 (APC −1.06*%, 95% CI: −2.12% to −0.26%), then rose to 74.3 in 2022 (APC 3.23*%, 95% CI: 2.18%–5.40%). …”

Table_2_Transcriptome in Combination Proteome Unveils the Phenylpropane Pathway Involved in Garlic (Allium sativum) Greening.XLSX by Jinxiang Wu (475283)

“…The greening phenomenon of garlic severely decreases the quality of garlic and hinders garlic processing. …”

Table_2_Initial Invasive or Conservative Strategy in Heart Failure With Preserved Ejection Fraction and Coronary Artery Disease.docx by Jun Gu (89637)

“…With a follow-up of 5 years, 378 (57.3%) in the invasive-strategy group and 403 (61.1%) in the conservative-strategy group reached the primary endpoint, and there was no significant difference in the rate of the primary endpoint (P = 0.162). …”

Erythrocyte-binding assay on transfected COS7 cells expressing different regions of PfRH1 before and after enzymatic treatment. by Xiaohong Gao (50514)

“…<p>(A) Chimeric constructs for the expression of different regions of <i>PfRH1</i> in 3D7. 3D7 clone <i>RH1</i> DNA sequence (Genbank accession no: AF533700) with intro spliced out includes signal sequence (SS, black) and Exon2 (grey) encoding a large extracellular domain and excludes transmembrane domain and cytoplastic tail. …”

Image 3_Impact of social factors and health campaigns on the burden of idiopathic epilepsy: an inequality, decomposition, generalized and synthetic difference-in-differences study.... by Xuewen Rong (6242657)

“…The slope index of inequality for the mortality burden decreased from 1.97 to 1.62. After the policy shock, the age-standardized rate (ASR) of years lived with disability (YLD) in the Caribbean increased significantly to 4.59 (95% CI: 0.96 to 8.22), while the all-age YLD rate in the U.S. increased (5.18, 95% CI: 0.66 to 9.70) for both sexes.…”

Image_3_The Pathogenic Effects of Fusobacterium nucleatum on the Proliferation, Osteogenic Differentiation, and Transcriptome of Osteoblasts.TIF by Hui Gao (169623)

“…Whole-transcriptome analyses identified a total of 235 transcripts that were differentially expressed in all six time points, most of which were inflammation-related genes. …”

Data_Sheet_1_Individual strategies in the rat gambling task are related to voluntary alcohol intake, but not sexual behavior, and can be modulated by naltrexone.docx by Nikita Tjernström (14049096)

“…Introduction<p>Gambling disorder (GD) is the first non-substance or behavioral addiction to be included in substance-related and addictive disorders in DSM-5. Since GD is a younger phenomenon relative to alcohol and substance use disorders, little is known about potential unique features in GD and to what extent characteristics are shared with alcohol and substance use disorders. …”

Amino Acid Oxidation of <i>Candida antarctica</i> Lipase B Studied by Molecular Dynamics Simulations and Site-Directed Mutagenesis by Mehdi Irani (1990660)

“…Molecular dynamics simulations have been performed on lipase B from <i>Candida antarctica</i> (CalB) in its native form and with one or two oxidized residues, either methionine oxidized to methionine sulfoxide, tryptophan oxidized to 5-hydroxytryptophan, or cystine oxidized to a pair of cysteic acid residues. …”