DKK1 Mediated Inhibition of Wnt Signaling in Postnatal Mice Leads to Loss of TEC Progenitors and Thymic Degeneration by Masako Osada (253586)

“…</p> <h3>Methodology/Principal Findings</h3><p>Here we demonstrate that tetracycline-regulated expression of the canonical Wnt inhibitor DKK1 in TECs localized in both the cortex and medulla of adult mice, results in rapid thymic degeneration characterized by a loss of ΔNP63⁺ Foxn1⁺ and Aire⁺ TECs, loss of K5K8DP TECs thought to represent or contain an immature TEC progenitor, decreased TEC proliferation and the development of cystic structures, similar to an aged thymus. …”

Image_1_Low-Dose Antibiotic Prophylaxis Induces Rapid Modifications of the Gut Microbiota in Infants With Vesicoureteral Reflux.JPEG by William Morello (10984251)

“…</p><p>Conclusions: In infants with VUR, even a short exposure to CAP definitely alters the GM composition, with increased relative abundance of opportunistic pathogens and decreased proportions of health-promoting taxa. …”

Type-Specific HPV Prevalence in Cervical Cancer and High-Grade Lesions in Latin America and the Caribbean: Systematic Review and Meta-Analysis by Agustín Ciapponi (202565)

“…The next five most common types, in decreasing frequency, were HPV 31, 58, 33, 45, and 52.…”

Simultaneous idiopathic bilateral sudden hearing loss - characteristics and response to treatment by Ferit Akil (4893706)

“…Results The mean ages of patients with unilateral and bilateral sudden hearing loss were 42.0 years and 24.5 years respectively with a statistically significant difference (p < 0.001). …”

Table_1_Irisin alleviated the reproductive endocrinal disorders of PCOS mice accompanied by changes in gut microbiota and metabolomic characteristics.doc by Meina Yang (5437790)

“…However, the mechanism remains vague. Irisin, a novel myokine, plays a positive role in the mediating effects of physical activity.…”

Image1_Metabolic Consequences of Developmental Exposure to Polystyrene Nanoplastics, the Flame Retardant BDE-47 and Their Combination in Zebrafish.jpeg by Raphaël Chackal (12093191)

“…Conversely, molecular gene expression data pointed to a negative interaction, as co-exposure of high PS generally abolished the induction of gene expression in response to BDE-47. …”

Image_1_The Val66 and Met66 Alleles-Specific Expression of BDNF in Human Muscle and Their Metabolic Responsivity.jpg by Gilmara Gomes de Assis (10748529)

“…Muscle biopsies from 13 male recreational athletes (34 ± 9 years, 1.80 ± 0.08 m, 76.4 ± 10.5 kg) were obtained before and immediately following a VO₂max test. …”

Table_2_The changes and its significance of peripheral blood NK cells in patients with tuberculous meningitis.DOCX by Jie Mi (152887)

“…The proportion of TBM patients (48.7%) with a lower absolute count of NK cells than the normal reference value was significantly higher than that in NC (5.2%) and LTBI groups (4.0%) (p < 0.05), and slightly higher than that in NSTB group (36.0%) (p > 0.05). …”

DataSheet_1_Comprehensive transcriptomic analysis of age-, dark-, and salt-induced senescence reveals underlying mechanisms and key regulators of leaf senescence in Zoysia japonica... by Lanshuo Wang (15995294)

“…In addition, we experimentally validated the senescence regulatory function of seven TFs including ZjNAP, ZjWRKY75, ZjARF2, ZjNAC1, ZjNAC083, ZjARF1, and ZjPIL5 using a protoplast-based senescence assay. This study provides new insight into the molecular mechanisms underlying Z. japonica leaf senescence and identifies potential genetic resources for enhancing its economic value by prolonging its green period.…”

Figures of manuscript "Fluvoxamine exerts anti-influenza(H1N1) effects through inhibiting apoptosis pathway" by Zhenqiao Wei (22372648)

“…This study evaluated the anti-influenza effects of fluvoxamine using H1N1-infected BALB/c mice and found that compared to the H1N1 infection group, the survival rate of mice in the fluvoxamine intervention group increased by 30% (50% <i>vs</i> 20%), with a decreased trend in body weight loss and improved lung tissue lesions. …”

Table_2_Magnetic Resonance Imaging Correlates of Immune Microenvironment in Glioblastoma.xlsx by Alessandro Salvalaggio (8780132)

“…MRI features may represent a novel tool for investigating the microenvironment of GBM.…”

Image_1_Optimization of Glycolipid Synthesis in Hydrophilic Deep Eutectic Solvents.JPEG by Rebecca Hollenbach (8756595)

“…However, DES are highly viscous systems and restricted mass transfer is likely to be a major limiting factor for their application. …”

DataSheet1_Dynamic and balanced regulation of the thrABC operon gene for efficient synthesis of L-threonine.docx by Ruxin Hao (14703649)

“…The results showed that higher expression of thrC than thrAB enhanced cell growth and L-threonine production; however, L-threonine production decreased when the thrC proportion was too high. The highest L-threonine production was achieved when the expression intensity ratio of thrAB to thrC was 3:5. …”

Image1_Modulation of the biological network of lumbar spinal stenosis by Tongdu Huoxue Decoction based on clinical metabolomics.PNG by Luhong Ji (14819746)

“…Regarding metabolomics, the levels of 41 differential metabolites were significantly different in the normal group (group NC) compared to group A, and those were significantly restored after treatment with THD, including chenodeoxycholic acid 3-sulfate, taurohyodeoxycholic acid, 3,5-Dihydroxy-4-methoxybenzoic acid, pinocembrin. …”

The Role of Hormones in the Differences in the Incidence of Breast Cancer between Mongolia and the United Kingdom by Rebecca Troisi (643668)

“…Hormone concentrations generally were similar in Mongolian women born in Ulaanbaatar compared with those born in rural areas, although there was a decreasing progesterone trend by degree of westernization (rural Mongolia; urban Mongolia; U.K.). …”

Data-driven exploration of new pressure-induced superconductivity in PbBi₂Te₄ by Ryo Matsumoto (527418)

“…The resistance decreased with increasing of the pressure, and pressure-induced superconducting transitions were discovered at 2.5 K under 10 GPa. …”

Presentation_1_Regulatory Role of Hexokinase 2 in Modulating Head and Neck Tumorigenesis.PPTX by Wan-Chun Li (450324)

“…Loss of HK2 in HNSCC cells resulted in reduced cell (in vitro) and tumor (in vivo) growth, as well as decreased epithelial-mesenchymal transition–mediated cell movement; in contrast, HK2-deficient HNSCC cells exhibited greater sensitivity to chemotherapeutic drugs cisplatin and 5-fluorouracil but are more resistant to photodynamic therapy, indicating that HK2 expression could selectively define treatment sensitivity in HNSCC cells. …”

Image_4_Low-Dose Antibiotic Prophylaxis Induces Rapid Modifications of the Gut Microbiota in Infants With Vesicoureteral Reflux.TIF by William Morello (10984251)

“…</p><p>Conclusions: In infants with VUR, even a short exposure to CAP definitely alters the GM composition, with increased relative abundance of opportunistic pathogens and decreased proportions of health-promoting taxa. …”

Data_Sheet_1_Threshold Reaction of Soil Arthropods to Simulative Nitrogen Deposition in Urban Green Spaces.pdf by Lingzi Mo (11645293)

“…Although higher doses of N addition showed adverse effects on soil fauna communities, low N inputs increased the soil fauna diversity and richness, especially at 5–10 cm depth. A threshold effect appears to exist low nitrogen addition (<25 kg N ha^–1) did not affect negatively pedofauna structure and composition, while in the range from these values up to 50 kg N ha^–1, the composition of the soil fauna underwent major changes confirmed by the decline of biodiversity indices. …”

Image_1_Fenofibrate Ameliorated Systemic and Retinal Inflammation and Modulated Gut Microbiota in High-Fat Diet-Induced Mice.pdf by Xue Wang (102830)

“…<p>Fenofibrate, as a lipid-lowering drug, has been reported to have a protective effect on the retina independent with plasma lipid levels. …”