Down-regulated TMED10 in Alzheimer disease induces autophagy via ATG4B activation by Ji Hyun Shin (659064)

“…To explore the molecular mechanisms of autophagy, we performed a cell-based functional screening with SH-SY5Y cells stably expressing GFP-LC3, using an siRNA library and identified TMED10 (transmembrane p24 trafficking protein 10), previously known as the γ-secretase-modulating protein, as a novel regulator of autophagy. …”

Dynamics of sub-RPE CNV to sub-retinal CNV progression (P13 Progression). by Abbas Shirinifard (53980)

“…<p>A) Total number of <b>stalk cells</b> vs. <b>time</b>. …”

Helical Conformational Dynamics and Photoisomerism of Alternating Pyridinedicarboxamide/<i>m</i>-(Phenylazo)azobenzene Oligomers by Chenyang Tie (2652985)

“…¹H NMR line shape analysis of the CBz methylene hydrogens at the chain ends revealed a dynamic equilibria interconverting <i>M</i> and <i>P</i> helical conformations with energetic barriers (Δ<i>G</i>^⧧) of 11.1 (Δ<i>S</i>^⧧ = −19.4 ± 1.6 cal mol^-1 K^-1; Δ<i>H</i>^⧧ = 6.5 ± 0.4 kcal/mol) for <b>8</b> and 13.8 kcal/mol (Δ<i>S</i>^⧧ = −6.6 ± 6.2 cal mol^-1 K^-1; Δ<i>H</i>^⧧ = 11.8 ± 1.8 kcal/mol) for <b>9</b>. …”

Table_1_An etude for post-pandemic practice: The impact of the COVID-19 pandemic on practice methods and instrumental technique.XLSX by Ellen Fallowfield (14287268)

“…Participants were statistically more likely to report “never” watching online tutorials than “often” (p = 0.014), but, of those that did watch such material, 75% agreed that it had a positive impact upon their practice. Most participants created digital content during this period; only 5% produced no such material. …”

Image 4_Integrated analysis of single-cell and bulk transcriptomics reveals the prognostic value and underlying mechanisms of crotonylation in ovarian cancer.tif by Xiaofeng Li (342614)

“…Background<p>Ovarian cancer remains the deadliest gynecological malignancy with 5-year survival rates below 40% due to frequent recurrence and chemoresistance. …”

microRNA 126 Inhibits the Transition of Endothelial Progenitor Cells to Mesenchymal Cells via the PIK3R2-PI3K/Akt Signalling Pathway by Junfeng Zhang (13013)

“…In the cellular process of EndMT, there was an increase in the protein expression of PIK3R2 and the nuclear transcription factors FoxO3 and Smad4; PI3K and phosphor-Akt expression decreased, a change that was reversed markedly by overexpression of miR-126. …”

Web-based interventions for traumatized people in mainland China by Jian-Ping Wang (8434)

“…In the rural sample, the group×time interaction was also significant in PDS scores (F1,91=5.35, <i>p</i>=0.02). Posttraumatic symptoms decreased significantly after intervention (F1,48=43.97, Cohen's <i>d</i>=1.34, <i>p</i><0.001) and during the follow-up period (F1,48=24.22, Cohen's <i>d</i>=0.99, <i>p</i><0.001).…”

image_2_Impaired Differentiation of Langerhans Cells in the Murine Oral Epithelium Adjacent to Titanium Dental Implants.jpeg by Oded Heyman (5139533)

“…Further analysis revealed that while the expression of the TGF-β1 canonical receptor activing-like kinase (ALK)5 was upregulated, expression of its non-canonical receptor ALK3 was decreased. …”

Table 6_Integrated analysis of single-cell and bulk transcriptomics reveals the prognostic value and underlying mechanisms of crotonylation in ovarian cancer.csv by Xiaofeng Li (342614)

“…Background<p>Ovarian cancer remains the deadliest gynecological malignancy with 5-year survival rates below 40% due to frequent recurrence and chemoresistance. …”

Antagonistic Regulation of Parvalbumin Expression and Mitochondrial Calcium Handling Capacity in Renal Epithelial Cells by Thomas Henzi (822552)

“…Using Gene Chip Arrays and qRT-PCR, we identified differentially expressed genes in the DCT of PV-/- mice. With a focus on genes implicated in mitochondrial Ca²⁺ transport and membrane potential, uncoupling protein 2 (<i>Ucp2</i>), mitocalcin (<i>Efhd1</i>), mitochondrial calcium uptake 1 (<i>Micu1</i>), mitochondrial calcium uniporter (<i>Mcu</i>), mitochondrial calcium uniporter regulator 1 (<i>Mcur1</i>), cytochrome c oxidase subunit 1 (<i>COX1</i>), and ATP synthase subunit β (<i>Atp5b</i>) were found to be up-upregulated. …”

Flexible Microfluidic Devices for Tunable Formation of Double Emulsion by Uditha Roshan (20841937)

Image_4_Initial WNT/β-Catenin Activation Enhanced Mesoderm Commitment, Extracellular Matrix Expression, Cell Aggregation and Cartilage Tissue Yield From Induced Pluripotent Stem Ce... by Ursula Kreuser (9581357)

“…Importantly, the initial CHIR pulse increased cell proliferation until day 14 (five-fold), adjusted expression of adhesion-related genes (CDH3 up, CDH6 down) and increased extracellular matrix (ECM)-related gene expression (COL6, COL1, COL3, COL5, DCN, NPNT, LUM, MGP, MATN2, and VTN), thus yielding more matrix-interacting progenitors with a high aggregation capability. …”

Flexible Microfluidic Devices for Tunable Formation of Double Emulsion by Uditha Roshan (20841937)

Flexible Microfluidic Devices for Tunable Formation of Double Emulsion by Uditha Roshan (20841937)

Table 1_Integrated analysis of single-cell and bulk transcriptomics reveals the prognostic value and underlying mechanisms of crotonylation in ovarian cancer.xlsx by Xiaofeng Li (342614)

“…Background<p>Ovarian cancer remains the deadliest gynecological malignancy with 5-year survival rates below 40% due to frequent recurrence and chemoresistance. …”

image_1_Impaired Differentiation of Langerhans Cells in the Murine Oral Epithelium Adjacent to Titanium Dental Implants.jpeg by Oded Heyman (5139533)

“…Further analysis revealed that while the expression of the TGF-β1 canonical receptor activing-like kinase (ALK)5 was upregulated, expression of its non-canonical receptor ALK3 was decreased. …”

Data_Sheet_1_Impact of Sleep–Wake-Associated Neuromodulators and Repetitive Low-Frequency Stimulation on Human iPSC-Derived Neurons.docx by Remi Yokoi (6750716)

“…The number of SBFs repeatedly increased up to 5 h after 100 nM serotonin administration, inducing a 24-h rhythm cycle. …”

MiR144/451 expression is epigenetically repressed during megakaryocytic differentiation. by Nicole Kohrs (3175914)

“…<p><b>(A)</b> MiR144/451 expression is decreased upon megakaryocytic differentiation and increased upon erythroid expression of primary hCD34+ cells. …”

Image_3_Cyclic Stretch Induces Vascular Smooth Muscle Cells to Secrete Connective Tissue Growth Factor and Promote Endothelial Progenitor Cell Differentiation and Angiogenesis.TIF by Jing Yan (312090)

“…In vitro, EPCs were cocultured with VSMCs, which were exposed to cyclic stretch at a magnitude of 5% (which mimics physiological stretch) and a constant frequency of 1.25 Hz for 12 h. …”

Flexible Microfluidic Devices for Tunable Formation of Double Emulsion by Uditha Roshan (20841937)