H1299 colony formation and proliferation after chemotherapy. by Elisabeth Silden (284167)

“…<p>(<b>A</b>) Colony formation assay of H1299 p53β, H1299 p53γ and H1299 vector control demonstrated significantly decreased colony formation in p53β⁺ and p53γ⁺ cells after seven-days treatment with 25 nM doxorubicin (Dox). …”

Image_1_D-Serine Contributes to Seizure Development via ERK Signaling.tif by Tie Ma (6505097)

“…L-aspartic acid β-hydroxamate (LaaβH), an inhibitor of SR, significantly prolonged the latencies of seizures, shortened the durations of seizures, and decreased the total EEG power in rats. In contrast, D-amino acid oxidase inhibitor 5-chlorobenzo[d]isoxazol-3-ol (CBIO), which can increase D-serine levels, showed the opposite effects. …”

DataSheet2_Mogrol Attenuates Osteoclast Formation and Bone Resorption by Inhibiting the TRAF6/MAPK/NF-κB Signaling Pathway In vitro and Protects Against Osteoporosis in Postmenopau... by Yongjie Chen (269938)

“…Furthermore, RT–PCR indicated that mogrol suppressed osteoclastogenesis-related gene expression, including CTSK, ACP5, MMP9 and DC-STAMP, in RANKL-induced bone marrow macrophages Western blotting demonstrated that mogrol suppressed osteoclast formation by blocking TNF receptor-associated factor 6 (TRAF6)-dependent activation of the mitogen-activated protein kinase nuclear factor-B (NF-κB) signaling pathway, which decreased two vital downstream transcription factors, the nuclear factor of activated T cells calcineurin-dependent 1 (NFATc1) and c-Fos proteins expression. …”

Table 3_Speckle tracking technology and investigation of risk factors for premature ventricular contraction-induced cardiomyopathy.pdf by Qiao Ma (136536)

“…This study aimed to evaluate the diagnostic utility of speckle tracking echocardiography (STE)-derived strain parameters in patients with frequent PVCs and to identify associated risk factors for early myocardial impairment.</p>Methods<p>A total of 258 patients with monomorphic PVCs and a PVC burden >5% on 24 h Holter monitoring were enrolled, along with 80 age- and sex-matched healthy controls. …”

Table_2_Plant Community Traits Respond to Grazing Exclusion Duration in Alpine Meadow and Alpine Steppe on the Tibetan Plateau.DOCX by Tianyu Zhan (8719563)

“…<p>Grazing exclusion has been a primary ecological restoration practice since the implement of “Returning Grazing Land to Grassland” program in China. …”

Mitochondria-Derived Reactive Oxygen Species Regulation of Tardigrade Osmobiosis Revealed by Proteomics of Hypsibius exemplaris by Evan R. Stair (17803878)

DataSheet_1_Gut microbiome variation in pulmonary TB patients with diabetes or HIV comorbidities.pdf by Portia Abena Morgan (11883253)

“…</p>Results<p>Compared to the healthy controls, the gut microbiome of all the TB cohorts was characterized by a significant decreased alpha diversity and significant compositional changes. …”

Image_1_Ductal Mucus Obstruction and Reduced Fluid Secretion Are Early Defects in Chronic Pancreatitis.jpeg by Anita Balázs (3239238)

“…Secretory mucins MUC6 and MUC5B were upregulated in human, Muc6 in mouse CP. …”

Image 1_Impact of social factors and health campaigns on the burden of idiopathic epilepsy: an inequality, decomposition, generalized and synthetic difference-in-differences study.... by Xuewen Rong (6242657)

“…The slope index of inequality for the mortality burden decreased from 1.97 to 1.62. After the policy shock, the age-standardized rate (ASR) of years lived with disability (YLD) in the Caribbean increased significantly to 4.59 (95% CI: 0.96 to 8.22), while the all-age YLD rate in the U.S. increased (5.18, 95% CI: 0.66 to 9.70) for both sexes.…”

Table_3_Relief of Cadmium-Induced Intestinal Motility Disorder in Mice by Lactobacillus plantarum CCFM8610.docx by Yang Liu (4829)

“…<p>Cadmium (Cd) is a toxic metal inducing a range of adverse effects on organs including liver and kidneys. …”

Data_Sheet_1_Genome-wide association study of coleoptile length with Shanxi wheat.docx by Naicui Wei (12000617)

“…In total, nine stable genetic loci were identified via 3VmrMLM under the three conditions, explaining 2.94–7.79% of phenotypic variation. Five loci on chromosome 2B, 3A, 3B, and 5B have not been reported previously. …”

Image_6_Evolutionary history of genus Coptis and its dynamic changes in the potential suitable distribution area.jpeg by Yiheng Wang (5448683)

“…<p>The genus Coptis belongs to the Ranunculaceae family, containing 15 recognized species highly diverse in morphology. It is a conspicuous taxon with special evolutionary position, distribution pattern and medicinal value, which makes it to be of great research and conservation significance. …”

Image_2_Apolipoprotein-E deficiency leads to brain network alteration characterized by diffusion MRI and graph theory.JPEG by Margaret Caroline Stapleton (17437713)

“…<p>Late-onset Alzheimer’s disease (LOAD) is a major health concern for senior citizens, characterized by memory loss, confusion, and impaired cognitive abilities. …”

Table_1_Effects of Soil Physico-Chemical Properties on Plant Species Diversity Along an Elevation Gradient Over Alpine Grassland on the Qinghai-Tibetan Plateau, China.docx by Wangya Han (12044681)

“…Alpine grassland on the QTP has suffered from a serious decline in plant species diversity. In this study, we investigated 112 sites recording plant community characteristics and collecting soil samples along an elevation gradient (3,500–5,200 m asl) in alpine meadow on the QTP. …”

Image1_Mogrol Attenuates Osteoclast Formation and Bone Resorption by Inhibiting the TRAF6/MAPK/NF-κB Signaling Pathway In vitro and Protects Against Osteoporosis in Postmenopausal... by Yongjie Chen (269938)

“…Furthermore, RT–PCR indicated that mogrol suppressed osteoclastogenesis-related gene expression, including CTSK, ACP5, MMP9 and DC-STAMP, in RANKL-induced bone marrow macrophages Western blotting demonstrated that mogrol suppressed osteoclast formation by blocking TNF receptor-associated factor 6 (TRAF6)-dependent activation of the mitogen-activated protein kinase nuclear factor-B (NF-κB) signaling pathway, which decreased two vital downstream transcription factors, the nuclear factor of activated T cells calcineurin-dependent 1 (NFATc1) and c-Fos proteins expression. …”

Predictive properties of DNA methylation patterns in primary tumor samples for osteosarcoma relapse status by Jeremy M Rosenblum (685905)

“…A locus at the <i>TLR4</i> gene demonstrates one of strongest associations between DNA methylation and 5 y event-free survival (<i>P</i>-value = 1.7 × 10⁻⁶), with empirical annotation of this locus showing promoter characteristics. …”

Table_4_Structure and Function of Oral Microbial Community in Periodontitis Based on Integrated Data.xlsx by Zhengwen Cai (10986837)

“…Objective<p>Microorganisms play a key role in the initiation and progression of periodontal disease. …”

Enhanced intrinsic excitability of spinal Calcrl⁺ neurons in chronic itch. by Huifeng Jiao (11537806)

“…Unchanged maximal rise slope <b>(G)</b>; Reduced half-width <b>(H)</b>; Decreased AHP amplitude <b>(I)</b>; Increased number of spikes upon 100 pA depolarization <b>(J)</b>. …”

DataSheet3_Mogrol Attenuates Osteoclast Formation and Bone Resorption by Inhibiting the TRAF6/MAPK/NF-κB Signaling Pathway In vitro and Protects Against Osteoporosis in Postmenopau... by Yongjie Chen (269938)

“…Furthermore, RT–PCR indicated that mogrol suppressed osteoclastogenesis-related gene expression, including CTSK, ACP5, MMP9 and DC-STAMP, in RANKL-induced bone marrow macrophages Western blotting demonstrated that mogrol suppressed osteoclast formation by blocking TNF receptor-associated factor 6 (TRAF6)-dependent activation of the mitogen-activated protein kinase nuclear factor-B (NF-κB) signaling pathway, which decreased two vital downstream transcription factors, the nuclear factor of activated T cells calcineurin-dependent 1 (NFATc1) and c-Fos proteins expression. …”

DataSheet1_Study on the anti-biofilm mechanism of 1,8-cineole against Fusarium solani species complex.docx by Yu Zhang (12946)

“…Notably, 1,8-cineole showed good anti-biofilm formation activity against F. solani via inhibiting cell adhesion, hypha formation and decreasing the secretion of extracellular matrix at the concentration of ≥5.76 μg/ml. …”