Effects of P-gp inhibition on the retention of daunorubicin in the multidrug resistant prostate cancer cell line, DU145TXR. by Amila K. Nanayakkara (6812384)

“…After washing the cells with cold PBS as described in Methods, fluorescence micrographs were obtained using a Cytation 5 imager and a Texas Red filter. The concentration of compound <b>29</b> was 25 μM and daunorubicin was 10 μM. …”

Image_3_Mitochondrial Dysfunction Inhibits Hypoxia-Induced HIF-1α Stabilization and Expression of Its Downstream Targets.TIF by Marike W. van Gisbergen (4330453)

“…Increased glycolysis was observed for cytoplasmic 143B mutant hybrid (m.3243A>G, >94.5%) cells (p < 0.05) and 143B mitochondrial DNA (mtDNA) depleted cells (p < 0.05). …”

Data_Sheet_1_Mitochondrial Dysfunction Inhibits Hypoxia-Induced HIF-1α Stabilization and Expression of Its Downstream Targets.pdf by Marike W. van Gisbergen (4330453)

“…Increased glycolysis was observed for cytoplasmic 143B mutant hybrid (m.3243A>G, >94.5%) cells (p < 0.05) and 143B mitochondrial DNA (mtDNA) depleted cells (p < 0.05). …”

Effect of Bronsted Acids and Bases, and Lewis Acid (Sn²⁺) on the Regiochemistry of the Reaction of Amines with Trifluoromethyl-β-diketones: Reaction of 3‑Aminopyrrole to... by Michael De Rosa (1915813)

Image_3_Inhibition of Heat Shock Protein 90 by 17-AAG Reduces Inflammation via P2X7 Receptor/NLRP3 Inflammasome Pathway and Increases Neurogenesis After Subarachnoid Hemorrhage in... by Yuchun Zuo (5933525)

“…Western blotting showed HSP90 levels to be decreased, while neurogenesis, evaluated by 5-bromo-2’-deoxyuridine (BrdU) immunohistochemistry, was decreased in the hippocampuses of SAH mice. …”

Image_1_Mitochondrial Dysfunction Inhibits Hypoxia-Induced HIF-1α Stabilization and Expression of Its Downstream Targets.TIF by Marike W. van Gisbergen (4330453)

“…Increased glycolysis was observed for cytoplasmic 143B mutant hybrid (m.3243A>G, >94.5%) cells (p < 0.05) and 143B mitochondrial DNA (mtDNA) depleted cells (p < 0.05). …”

Image_4_Mitochondrial Dysfunction Inhibits Hypoxia-Induced HIF-1α Stabilization and Expression of Its Downstream Targets.TIF by Marike W. van Gisbergen (4330453)

“…Increased glycolysis was observed for cytoplasmic 143B mutant hybrid (m.3243A>G, >94.5%) cells (p < 0.05) and 143B mitochondrial DNA (mtDNA) depleted cells (p < 0.05). …”

Neuronal loss of the <i>LZTR1</i> homolog <i>night owl</i> (<i>nowl)</i> reduces night-time sleep in <i>Drosophila</i>. by Gianna W. Maurer (6103637)

“…(B) Schematic of the <i>nowl</i> locus. The gene comprises 5′ and 3′ untranslated regions (light grey) and a multi-exon coding region (dark grey). …”

Only at very high concentrations Orco antagonist OLC15 (100 μM) inhibited the immediate pheromone response. by Andreas Nolte (409768)

“…<p>While intermediate concentrations (10 μM) of OLC15 did not change the sensillum potential amplitude (SPA) and the frequency of the first 10 bombykal-dependent APs, higher OLC15 concentrations significantly decreased both parameters during activity and rest (A-D). …”

Transposon disruption of candidate macrophage pathogenesis genes. by Dustin R. Long (11565529)

“…Boxes indicate median, 25^th, and 75^th percentiles with whiskers extending to the most distant value < 1.5 times the interquartile range. Red horizontal lines indicate the 95% confidence interval of all JE2 control measurements, with significant mutants defined as having a median measurement outside this range. …”

Image_1_Auxiliary Subunits Regulate the Dendritic Turnover of AMPA Receptors in Mouse Hippocampal Neurons.pdf by Ali Harb (5734601)

“…An analysis of intracellular receptor distribution also revealed a decreased receptor pool in dendritic recycling endosomes, suggesting that incorporation of TARPγ-8 or CKAMP44a in receptor complexes generally diminishes cycling through the endosomal compartment. …”

Representation of phenotypes. by Nicole L. Washington (256874)

“…For zebrafish, the mutants express a variable and modifiable phenotype that consists of decreased eye size, reduced lens size, and malformation of the retina. …”

Fig 2 - by Jakub Jurasz (11530516)

“…For the discussion of an alternative pathway, cf. <a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1009454#pcbi.1009454.s005" target="_blank">S5 Fig</a>.…”

Awareness of disabilities in pharmacy program recruitment material: are we doing enough? by Hussain, Farhat Naz

“…Introduction: Targeted recruitment of students with disabilities is a novel area in pharmacy education and may help to attract qualified students in light of decreasing applicant numbers. …”
Get full text
Get full text

Image_1_Transcriptome analysis reveals the effect of cold storage time on the expression of genes related to oxidative metabolism in Chinese black truffle.pdf by Runji Zhang (8895482)

“…Ribulose-5-phosphate-3-epimerase (RPE) was a key enzyme in response to oxidative stress in truffle cells through the pentose phosphate pathway (PPP). …”

Data Sheet 1_HLA class, calcineurin inhibitor levels, and the risk of graft failure in kidney recipients with de novo donor-specific antibodies.pdf by Marc-Antoine Béland (20294229)

“…Additionally, the risk of graft loss decreased with increasing CNI trough levels following dnDSA detection (aHR 0.7 [0.6-0.9] for each increase in 1 ng/mL, p=0.02).…”

Image_4_Investigation of the growth performance, blood status, gut microbiome and metabolites of rabbit fed with low-nicotine tobacco.JPEG by Changliang Jing (5106365)

“…The objective of this study was to evaluate the effects of dietary addition of low-nicotine tobacco (LNT) on the growth performance, blood status, cecum microbiota and metabolite composition of meat rabbits. A total of 80 Kangda meat rabbits of similar weight were assigned randomly as four groups, and three of them were supplemented with 5%, 10%, and 20% LNT, respectively, with the other one fed with basal diet as control group. …”

Life Cycle Assessment to Quantify Global Warming and Human Health–Respiratory Impacts of Using Composites from Waste Wind Turbine Blades as Feedstock for Cement Clinker and Fibergl... by Caroline V. Cameron (22355207)

<i>Neurog1</i> expression in organ of Corti cells affects afferent and efferent innervation. by Israt Jahan (130375)

“…<p>In E18.5 wild-type mice, Sox2 is present in the GER and in all supporting cells (a) and many radial fibers project to inner hair cells. …”

Age at the time of infection influences the host immune response to RSV. by Asuncion Mejias (173484)

“…(D) Modular analysis in the two age groups revealed a similar trend in the overexpression of neutrophil-related genes (M5.15) and the suppression of genes related to T cells (M4.1, M4.15), lymphoid lineage (M6.19), and antimicrobial response (M2.1). …”