Structure–Activity Studies of 1<i>H</i>‑Imidazo[4,5‑<i>c</i>]quinolin-4-amine Derivatives as A₃ Adenosine Receptor Positive Allosteric Modulators by Lucas B. Fallot (14106171)

“…Although having low Caco-2 permeability and high plasma protein binding, hydrophobic 2-cyclohept-4-enyl-<i>N</i>-3,4-dichlorophenyl, MRS7788 <b>18</b>, and 2-heptan-4-yl-<i>N</i>-4-iodophenyl, MRS8054 <b>39</b>, derivatives were orally bioavailable in rat. 2-Heptan-4-yl-<i>N</i>-3,4-dichlorophenyl <b>14</b> and 2-cyclononyl-<i>N</i>-3,4-dichlorophenyl <b>20</b> derivatives and <b>39</b> greatly enhanced Cl-IB-MECA-stimulated [³⁵S]GTPγS binding <i>E</i>_max, with only <b>12b</b> trending toward decreasing the agonist EC₅₀. …”

At 40-50 hpf, the zebrafish heart begins to undergo looping. by Juhyun Lee (449913)

The 50 pentatonic scales whose intervals conform most closely to a harmonic series out of ∼4×10⁵ possibilities examined. by Kamraan Z. Gill (368776)

50 year-old man with adenovirus type 55 pneumonia. by Dingyu Tan (3180789)

Skin histology in control and obesity groups. by Yoshiko Horie (4923043)

50% reduction of kinesin-1 perturbs the movement of APP vesicles. by Gary J. Iacobucci (192833)

“…<p>(<b>A</b>) A representative movie montage from a single neuron is shown from a primary neuronal culture expressing APP-YFP in the context of 100% kinesin-1 (APP-YFP) or 50% kinesin-1 (APP-YFP;khc²⁰−/+). …”

Gossypol prevents bleomycin-induced pulmonary fibrosis. by Jennifer L. Judge (5278415)

Biochemical and immunological characterization of Cx50 and Cx46 proteins. by Chun-hong Xia (292212)

“…<p>(<b>A</b>) Total lens homogenates, prepared from <i>Gja8^R205G/R205G</i> (a), <i>Gja8^R205G/−</i> (b) and <i>Gja8^−/−</i> (c) littermates at one week of age, were examined by a Coomassie-blue stained gel (left panel) and by western blot using an anti-Cx50 antibody and an anti-Cx46 antibody (right panels). …”

GFP-Osy localizes to pore canals. by Yiwen Wang (666361)

The behavioural quantities of 50 young zebrafish (group Y1). by Yushi Yang (1755760)

“…C: Sequence of radial distribution functions with increasing time: at early times (top curves) the fish are clustered together so that the peak is large; at later times (bottom curves) the local density decreases and so does the peak height. D: The time evolution of the averaged behavioural quantities for 50 young fish. …”

Dysfunction of Oskyddad causes Harlequin-type ichthyosis-like defects in <i>Drosophila melanogaster</i> by Yiwen Wang (666361)

“…Land insects have an extracellular coat, the cuticle, that plays a major role in protection against exaggerated water loss. Here, we report that the ABC transporter Oskyddad (Osy)—a human ABCA12 paralog—contributes to the waterproof barrier function of the cuticle in the fruit fly <i>Drosophila melanogaster</i>. …”

The expulsion of <i>T</i>. <i>spiralis</i> is affected by the gut microbiota and dependent on the host’s mucosal immunity. by Chengyao Li (311264)

Gossypol inhibits LDH activity and prevents TGF-β1 expression and activation. by Jennifer L. Judge (5278415)

We estimated the frame-shift mutation rate in the real genomes, and in randomized genomes without context-dependent codon choice by Roger M Wanner (93314)

Number of ambulation, rearing, and tremor bouts in control and after 4-aminopyridine administration in male <i>taiep</i> rats. by Jose R. Eguibar (8563227)

Gossypol prevents TGF-β1 induced fibronectin expression. by Jennifer L. Judge (5278415)

Gossypol treats bleomycin-induced fibronectin expression. by Jennifer L. Judge (5278415)

Osy is a half-type ABC transporter. by Yiwen Wang (666361)

Table_1_Why Does Child Mortality Decrease With Age? Modeling the Age-Associated Decrease in Mortality Rate Using WHO Metadata From 25 Countries.XLSX by Josef Dolejs (5534258)

Frequency of the number of peaks (<i>N</i>_pics) (black, left vertical axis) and average amplitude of pics (<i>A</i>_pics) (red, right vertical axis) observed i... by Sławomir Grzegorczyn (12035398)