Citrulline a More Suitable Substrate than Arginine to Restore NO Production and the Microcirculation during Endotoxemia by Karolina A. P. Wijnands (162718)

“…Improving the organ perfusion in endotoxemia, as often seen in patients with severe infection or systemic inflammatory response syndrome (SIRS) is, therefore, an important therapeutic target. We hypothesized that supplementation of the arginine precursor citrulline rather than arginine would specifically increase eNOS-induced intracellular NO production and thereby improve the microcirculation during endotoxemia.…”

DataSheet_1_Long-Term Effects of Alemtuzumab on CD4+ Lymphocytes in Multiple Sclerosis Patients: A 72-Month Follow-Up.pdf by Simona Rolla (6181838)

“…Furthermore, a significant decrease in self-reactive myelin basic protein-specific Th17 (p < 0.0001) and Th1 (p < 0.05) cells reaching HS values was observed starting from month 12. …”

Differential Expression of microRNAs in <i>Francisella tularensis</i>-Infected Human Macrophages: miR-155-Dependent Downregulation of MyD88 Inhibits the Inflammatory Response by Sarmistha Bandyopadhyay (641461)

“…Kinetic analyses indicated that miR-155 increased progressively 3-18 hours after infection with LVS or Schu S4, and target proteins disappeared after 12–18 hours. Dynamic modulation of MyD88 and SHIP-1 was confirmed using specific pre-miRs and anti-miRs to increase and decrease miR-155 levels, respectively. …”

Mobilized teams grew to a variety of sizes at a variety of rates. by Jeff Alstott (3282036)

“…(<b>B</b>–<b>C</b>) Using a similar social mobilization incentive system to that used in the present study, previous research suggested the distributions of team sizes and of recruiters' number of recruits followed power laws, with α of 1.96 and 1.69, respectively <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0095140#pone.0095140-Pickard1" target="_blank">[12]</a>. We used the statistical methods of Clauset et al. …”

Image_6_Pro-Inflammatory Implications of 2-Hydroxypropyl-β-cyclodextrin Treatment.tif by Tom Houben (3185082)

“…Given its potential as a therapeutic compound in metabolic inflammatory diseases, in this study, we evaluated the inflammatory effects of CD administration in the context of cholesterol-induced metabolic inflammation in vivo and in vitro. …”

Image_4_Pro-Inflammatory Implications of 2-Hydroxypropyl-β-cyclodextrin Treatment.tif by Tom Houben (3185082)

“…Given its potential as a therapeutic compound in metabolic inflammatory diseases, in this study, we evaluated the inflammatory effects of CD administration in the context of cholesterol-induced metabolic inflammation in vivo and in vitro. …”

Video_1_Pro-Inflammatory Implications of 2-Hydroxypropyl-β-cyclodextrin Treatment.mov by Tom Houben (3185082)

“…Given its potential as a therapeutic compound in metabolic inflammatory diseases, in this study, we evaluated the inflammatory effects of CD administration in the context of cholesterol-induced metabolic inflammation in vivo and in vitro. …”

Data_Sheet_1_Prevalence and determinants of developmental delay among children in low- and middle-income countries: a systematic review and meta-analysis.docx by Tesfaye Wondmagegn (18285487)

“…Therefore, strategies should be designed to decrease the rate of low birth weight and the number of illiterate mothers living in low- and middle-income countries.…”

Table_1_Impact of BCG vaccination on the repertoire of human γδ T cell receptors.xlsx by Mei Xia (104212)

“…</p>Methods<p>In this study we performed γδ T cell receptor (TCR) repertoire sequencing of samples provided pre- and post-BCG vaccination from 10 individuals to identify specific receptors and TCR clones that are induced by BCG.…”

Image_2_Paternal Resistance Training Modulates Calcaneal Tendon Proteome in the Offspring Exposed to High-Fat Diet.tif by Ivo Vieira de Sousa Neto (8977685)

“…Wistar rats were randomly divided into two groups: sedentary fathers and trained fathers (8 weeks, three times per week, with 8–12 dynamic movements per climb in a stair climbing apparatus). …”

Table3_The incidence, mortality and disease burden of cardiovascular diseases in China: a comparative study with the United States and Japan based on the GBD 2019 time trend analys... by Menglan Zhu (10268801)

“…</p>Results<p>In 2019, there were approximately 12,341,074 new diagnosed cases of CVDs in China, with 4,584,273 CVDs related deaths, causing 91,933,122 DALYs. …”

Image4_Clinical Efficacy and Safety of Different Doses of Sildenafil in the Treatment of Persistent Pulmonary Hypertension of the Newborn: A Network Meta-analysis.TIF by Linli Sun (11475766)

“…The network meta-analysis revealed that 1.5 mg/kg of sildenafil led to a significant decrease in pulmonary artery systolic pressure (PASP) compared with 0.3 and 0.6 mg/kg (p < 0.05); 1.5 mg/kg was better than 0.3, 0.5, and 1.0 mg/kg at increasing the partial pressure of oxygen (PaO₂) (p < 0.05); 1.5 mg/kg was better than 0.5, 0.6 and 1.0 mg/kg at reducing the partial pressure of carbon dioxide (PaCO₂) (p < 0.05); and 1.2 mg/kg was better than 0.3, 0.5 and 1.0 mg/kg at increasing the arterial oxygen saturation (SaO₂) (p < 0.05). …”

Data_Sheet_1_Paternal Resistance Training Modulates Calcaneal Tendon Proteome in the Offspring Exposed to High-Fat Diet.docx by Ivo Vieira de Sousa Neto (8977685)

“…Wistar rats were randomly divided into two groups: sedentary fathers and trained fathers (8 weeks, three times per week, with 8–12 dynamic movements per climb in a stair climbing apparatus). …”

Image_2_Real clinical experience after one year of treatment with tolvaptan in patients with autosomal dominant polycystic kidney disease.JPEG by Javier Naranjo (13879235)

“…The decrease in eGFR in the first month was higher in patients with an initially higher eGFR. …”

Image_4_Real clinical experience after one year of treatment with tolvaptan in patients with autosomal dominant polycystic kidney disease.JPEG by Javier Naranjo (13879235)

“…The decrease in eGFR in the first month was higher in patients with an initially higher eGFR. …”

Update on the current status of onchocerciasis in Côte d’Ivoire following 40 years of intervention: Progress and challenges by Benjamin G. Koudou (417273)

“…Onchocerciasis and lymphatic filariasis (LF) are co-endemic in 46 of the 81 health districts in the country. Fourteen and 12 districts are endemic for only LF or onchocerciasis, respectively. …”

Image_2_Differential physiological and production responses of C3 and C4 crops to climate factor interactions.jpg by Emmanuel Opoku (11195298)

“…Due to differences in photosynthetic metabolism in C3 barley and C4 sorghum, leading to different responses to elevated CO₂ concentration, we hypothesized mitigation of the negative drought impact in barley under elevated CO₂ concentration and, conversely, improved performance of sorghum at high temperatures. …”

Image_2_Clinical study on sequential treatment of severe diarrhea irritable bowel syndrome with precision probiotic strains transplantation capsules, fecal microbiota transplantati... by Linling Lv (12261320)

“…</p>Results<p>It was found that the IBS-SSS score of patient case 1 decreased by 175 points and that of patient case 2 decreased by 100 points after treatment of precision probiotic strains transplantation capsules. …”

DataSheet_1_Soil quality and ecological benefits assessment of alpine desertified grassland following different ecological restoration measures.docx by Yiran Li (1818355)

“…The increasing rate of SQI began to decrease after 5 years in EG and ESG, while it decreased after 7–9 years in ESSG, and that of EREI in EG was lower than ESSG in each restoration year. …”

Effect of tourniquet use during total knee arthroplasty on global inflammatory cytokine changes associated with ischemia- reperfusion injury by E. Todd Schroeder (4091569)

“…Overall, both pro-inflammatory and anti-inflammatory cytokines (including tumor necrosis factor-α, interleukin 1β, 4, 5, 12, and monocyte chemtactic protein-1) were found to increase upon application of tourniquets during cementation and decrease without tourniquet use or upon application of operative tourniquets. …”